MA55695A - Composés chimiques comme inhibiteurs de l'activité interleukine-1 - Google Patents
Composés chimiques comme inhibiteurs de l'activité interleukine-1Info
- Publication number
- MA55695A MA55695A MA055695A MA55695A MA55695A MA 55695 A MA55695 A MA 55695A MA 055695 A MA055695 A MA 055695A MA 55695 A MA55695 A MA 55695A MA 55695 A MA55695 A MA 55695A
- Authority
- MA
- Morocco
- Prior art keywords
- interleukin
- inhibitors
- activity
- chemical compounds
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201762449431P | 2017-01-23 | 2017-01-23 | |
US201762492813P | 2017-05-01 | 2017-05-01 |
Publications (1)
Publication Number | Publication Date |
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MA55695A true MA55695A (fr) | 2022-02-23 |
Family
ID=61189525
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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MA055695A MA55695A (fr) | 2017-01-23 | 2018-01-22 | Composés chimiques comme inhibiteurs de l'activité interleukine-1 |
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EP (2) | EP3851434A1 (fr) |
JP (1) | JP7163293B2 (fr) |
KR (1) | KR20190111068A (fr) |
CN (1) | CN110366549A (fr) |
AU (1) | AU2018210525B2 (fr) |
BR (1) | BR112019014549A2 (fr) |
CA (1) | CA3047336A1 (fr) |
CL (1) | CL2019001988A1 (fr) |
CO (1) | CO2019009036A2 (fr) |
CR (1) | CR20190356A (fr) |
IL (1) | IL267961B2 (fr) |
MA (2) | MA55695A (fr) |
MX (1) | MX2019008592A (fr) |
MY (1) | MY197636A (fr) |
PE (1) | PE20191615A1 (fr) |
PH (1) | PH12019501611A1 (fr) |
SG (1) | SG11201906373VA (fr) |
TW (1) | TW201837021A (fr) |
UA (1) | UA126675C2 (fr) |
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Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3851434A1 (fr) | 2017-01-23 | 2021-07-21 | Genentech, Inc. | Composés chimiques comme inhibiteurs de l'activité interleukine-1 |
JP7072586B2 (ja) | 2017-05-24 | 2022-05-20 | ザ ユニバーシティ オブ クィーンズランド | 新規な化合物及び使用 |
TWI789401B (zh) | 2017-07-07 | 2023-01-11 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
CU24615B1 (es) | 2017-07-24 | 2022-07-08 | Novartis Ag | Compuestos para tratar afecciones asociadas con la actividad nlrp |
UY37847A (es) | 2017-08-15 | 2019-03-29 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3 |
BR112020002906A2 (pt) | 2017-08-15 | 2020-08-04 | Inflazome Limited | novos compostos de sulfonamida-carboxamida |
WO2019034697A1 (fr) * | 2017-08-15 | 2019-02-21 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
US20210122739A1 (en) * | 2017-08-15 | 2021-04-29 | Inflazome Limited | Novel sulfonamide carboxamide compounds |
US11926600B2 (en) | 2017-08-15 | 2024-03-12 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
UY37848A (es) * | 2017-08-15 | 2019-03-29 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3 |
CN111315733A (zh) * | 2017-11-09 | 2020-06-19 | 英夫拉索姆有限公司 | 新颖磺酰胺甲酰胺化合物 |
EP3759073A1 (fr) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Dérivés de sulfonamide utilisés en tant qu'inhibiteurs de nlrp3 |
EP3759077A1 (fr) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Nouveaux composés |
EP3759102A1 (fr) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Nouveaux composés |
US20210261512A1 (en) | 2018-05-04 | 2021-08-26 | Inflazome Limited | Novel compounds |
CN112513048A (zh) * | 2018-07-20 | 2021-03-16 | 豪夫迈·罗氏有限公司 | 作为白细胞介素-1活性抑制剂的磺酰亚胺酰胺类化合物 |
CA3104199A1 (fr) * | 2018-07-20 | 2020-01-23 | F. Hoffmann-La Roche Ag | Composes de sulfonyluree en tant qu'inhibiteurs de l'activite de l'interleukine 1 |
BR112021002770A2 (pt) | 2018-08-15 | 2021-05-04 | Inflazome Limited | compostos inovadores de sulfonamidaurea |
GB201902327D0 (en) | 2019-02-20 | 2019-04-03 | Inflazome Ltd | Novel compounds |
GB201817038D0 (en) * | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
CN113347970A (zh) * | 2018-10-24 | 2021-09-03 | 诺华股份有限公司 | 用于治疗与nlrp活性相关的病症的化合物和组合物 |
WO2020086732A1 (fr) | 2018-10-24 | 2020-04-30 | Novartis Inflammasome Research, Inc. | Composés et compositions pour traiter des états associés à l'activité des nlrp |
GB201819083D0 (en) | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
EA202191968A1 (ru) | 2019-01-14 | 2021-11-16 | Кадила Хелзкэр Лимитед | Новые замещенные производные сульфонилмочевины |
EP3929185A4 (fr) * | 2019-02-19 | 2023-02-15 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Composé cyclique condensé contenant de l'azote, son procédé de préparation et son utilisation |
GB201905265D0 (en) | 2019-04-12 | 2019-05-29 | Inflazome Ltd | Inflammasome inhibition |
US20220378801A1 (en) | 2019-06-21 | 2022-12-01 | Ac Immune Sa | Novel compounds |
CN114555571A (zh) * | 2019-07-17 | 2022-05-27 | 祖玛珍生物科学有限公司 | 作为用于治疗多发性硬化症(MS)的NLPR3调节剂的N-((1,2,3,5,6,7-六氢-s-引达省-4-基)氨甲酰基)-4,5,6,7-四氢苯并呋喃-2-磺酰胺衍生物和相关化合物 |
CN114555569A (zh) * | 2019-07-17 | 2022-05-27 | 祖玛珍生物科学有限公司 | Nlrp3调节剂 |
EP4013761A1 (fr) | 2019-08-16 | 2022-06-22 | Inflazome Limited | Dérivés de sulfonylurée macrocycliques utiles en tant qu'inhibiteurs de nlrp3 |
US20220289692A1 (en) | 2019-09-06 | 2022-09-15 | Inflazome Limited | Nlrp3 inhibitors |
US11976054B2 (en) | 2019-11-12 | 2024-05-07 | Chengdu Baiyu Pharmaceutical Co., Ltd. | Amide derivative and preparation method therefore and use thereof in medicine |
WO2021165245A1 (fr) | 2020-02-18 | 2021-08-26 | Inflazome Limited | Composés |
JP2023518044A (ja) | 2020-03-16 | 2023-04-27 | ズーマゲン バイオサイエンシーズ エルティーディー | Nlrp3モジュレーター |
IL299084A (en) | 2020-06-19 | 2023-02-01 | Ac Immune Sa | History of dihydrooxazole and thiourea or urea modulating the NLRP3 inflammasome pathway |
CN114516878B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
CN114539256B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
WO2023116812A1 (fr) * | 2021-12-22 | 2023-06-29 | 瑞石生物医药有限公司 | Composé de sulfonylurée |
WO2023118521A1 (fr) | 2021-12-22 | 2023-06-29 | Ac Immune Sa | Composés dérivés de dihydro-oxazol |
WO2023211929A1 (fr) * | 2022-04-25 | 2023-11-02 | Vanderbilt University | Sondes et méthodes de visualisation ciblée d'inflammasomes nlrp3 |
US20240034735A1 (en) | 2022-07-14 | 2024-02-01 | Ac Immune Sa | Novel compounds |
US20240101563A1 (en) | 2022-07-28 | 2024-03-28 | Ac Immune Sa | Novel compounds |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5216026A (en) | 1990-07-17 | 1993-06-01 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
ATE242208T1 (de) | 1997-01-29 | 2003-06-15 | Pfizer | Sulfonylharnstoff-derivate und ihre verwendung in der kontrolle der interleukin-1-aktivität |
CA2383026A1 (fr) | 1999-09-14 | 2001-03-22 | Pfizer Products Inc. | Traitement combine au moyen de il-1ra et de composes de diarylsulfonyluree |
MXPA04002565A (es) | 2001-11-30 | 2004-05-31 | Pfizer Prod Inc | Combinacion de un inhibidor de il-1/18 con un inhibidor de tnf para el tratamiento de inflamacion. |
JP6152643B2 (ja) | 2010-02-22 | 2017-06-28 | 株式会社AskAt | Il−23媒介疾患を治療するためのep4受容体拮抗薬の使用 |
TW201311693A (zh) | 2011-09-02 | 2013-03-16 | Kyowa Hakko Kirin Co Ltd | 化學激活激素受體活性調節劑 |
JP2016522831A (ja) * | 2013-05-21 | 2016-08-04 | ヴァージニア コモンウェルス ユニバーシティ | 炎症を予防および治療するためのクリオピリン阻害剤 |
MD3259253T2 (ro) * | 2015-02-16 | 2020-06-30 | Univ Queensland | Sulfoniluree și compuși înrudiți și utilizări ale acestora |
FR3046933B1 (fr) | 2016-01-25 | 2018-03-02 | Galderma Research & Development | Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires |
US11858922B2 (en) | 2016-02-16 | 2024-01-02 | The University Of Queensland | Sulfonylureas and related compounds and use of same |
EP3445749B1 (fr) | 2016-04-18 | 2022-12-21 | Novartis AG | Composés et compositions destinés au traitement d'états associés à une activité de nlrp |
EP3872070A1 (fr) | 2016-04-18 | 2021-09-01 | Novartis AG | Composés et compositions pour traiter des états associés à une activité de nlrp |
EP3851434A1 (fr) | 2017-01-23 | 2021-07-21 | Genentech, Inc. | Composés chimiques comme inhibiteurs de l'activité interleukine-1 |
JP7072586B2 (ja) | 2017-05-24 | 2022-05-20 | ザ ユニバーシティ オブ クィーンズランド | 新規な化合物及び使用 |
TWI789401B (zh) | 2017-07-07 | 2023-01-11 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
EP3649112A1 (fr) | 2017-07-07 | 2020-05-13 | Inflazome Limited | Sulfonylurées et sulfonylthiourées en tant qu'inhibiteurs de nlrp3 |
UY37847A (es) | 2017-08-15 | 2019-03-29 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3 |
RU2020110366A (ru) | 2017-08-15 | 2021-09-16 | Инфлазоум Лимитед | Новые соединения сульфонамидкарбоксамидов |
BR112020002906A2 (pt) | 2017-08-15 | 2020-08-04 | Inflazome Limited | novos compostos de sulfonamida-carboxamida |
US11926600B2 (en) | 2017-08-15 | 2024-03-12 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
US20210122739A1 (en) | 2017-08-15 | 2021-04-29 | Inflazome Limited | Novel sulfonamide carboxamide compounds |
WO2019034697A1 (fr) | 2017-08-15 | 2019-02-21 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
UY37848A (es) | 2017-08-15 | 2019-03-29 | Inflazome Ltd | Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3 |
WO2019043610A1 (fr) | 2017-08-31 | 2019-03-07 | Cadila Healthcare Limited | Nouveaux dérivés de sulfonylurées substitués |
WO2019092172A1 (fr) | 2017-11-09 | 2019-05-16 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
EP3707137A1 (fr) | 2017-11-09 | 2020-09-16 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
CN111315733A (zh) | 2017-11-09 | 2020-06-19 | 英夫拉索姆有限公司 | 新颖磺酰胺甲酰胺化合物 |
GB201721185D0 (en) | 2017-12-18 | 2018-01-31 | Nodthera Ltd | Sulphonyl urea derivatives |
GB201803393D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
GB201803394D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
EP3759077A1 (fr) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Nouveaux composés |
GB201806578D0 (en) | 2018-04-23 | 2018-06-06 | Inflazome Ltd | Novel compound |
JP2021529187A (ja) | 2018-07-03 | 2021-10-28 | ノバルティス アーゲー | Nlrpモジュレータ |
CN112513048A (zh) | 2018-07-20 | 2021-03-16 | 豪夫迈·罗氏有限公司 | 作为白细胞介素-1活性抑制剂的磺酰亚胺酰胺类化合物 |
CA3104199A1 (fr) | 2018-07-20 | 2020-01-23 | F. Hoffmann-La Roche Ag | Composes de sulfonyluree en tant qu'inhibiteurs de l'activite de l'interleukine 1 |
GB201902327D0 (en) | 2019-02-20 | 2019-04-03 | Inflazome Ltd | Novel compounds |
BR112021002770A2 (pt) | 2018-08-15 | 2021-05-04 | Inflazome Limited | compostos inovadores de sulfonamidaurea |
GB201817038D0 (en) | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
WO2020086732A1 (fr) | 2018-10-24 | 2020-04-30 | Novartis Inflammasome Research, Inc. | Composés et compositions pour traiter des états associés à l'activité des nlrp |
GB201819083D0 (en) | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
-
2018
- 2018-01-22 EP EP20212018.4A patent/EP3851434A1/fr not_active Withdrawn
- 2018-01-22 MX MX2019008592A patent/MX2019008592A/es unknown
- 2018-01-22 MY MYPI2019004010A patent/MY197636A/en unknown
- 2018-01-22 AU AU2018210525A patent/AU2018210525B2/en active Active
- 2018-01-22 JP JP2019539814A patent/JP7163293B2/ja active Active
- 2018-01-22 CA CA3047336A patent/CA3047336A1/fr active Pending
- 2018-01-22 WO PCT/US2018/014728 patent/WO2018136890A1/fr active Application Filing
- 2018-01-22 PE PE2019001474A patent/PE20191615A1/es unknown
- 2018-01-22 TW TW107102246A patent/TW201837021A/zh unknown
- 2018-01-22 CN CN201880014694.0A patent/CN110366549A/zh active Pending
- 2018-01-22 MA MA055695A patent/MA55695A/fr unknown
- 2018-01-22 CR CR20190356A patent/CR20190356A/es unknown
- 2018-01-22 KR KR1020197024262A patent/KR20190111068A/ko active IP Right Grant
- 2018-01-22 UA UAA201907805A patent/UA126675C2/uk unknown
- 2018-01-22 SG SG11201906373VA patent/SG11201906373VA/en unknown
- 2018-01-22 BR BR112019014549-4A patent/BR112019014549A2/pt active Search and Examination
- 2018-01-22 EP EP18704341.9A patent/EP3571187B1/fr active Active
- 2018-01-22 MA MA047308A patent/MA47308A/fr unknown
-
2019
- 2019-07-09 PH PH12019501611A patent/PH12019501611A1/en unknown
- 2019-07-10 IL IL267961A patent/IL267961B2/en unknown
- 2019-07-15 CL CL2019001988A patent/CL2019001988A1/es unknown
- 2019-07-16 US US16/513,621 patent/US11040985B2/en active Active
- 2019-08-21 CO CONC2019/0009036A patent/CO2019009036A2/es unknown
-
2021
- 2021-01-25 US US17/157,749 patent/US20210395268A1/en not_active Abandoned
-
2022
- 2022-03-03 US US17/686,183 patent/US11702428B2/en active Active
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