MA50609A - Énantiomères de thiazoles substitués utilisés comme composés antiviraux - Google Patents
Énantiomères de thiazoles substitués utilisés comme composés antivirauxInfo
- Publication number
- MA50609A MA50609A MA050609A MA50609A MA50609A MA 50609 A MA50609 A MA 50609A MA 050609 A MA050609 A MA 050609A MA 50609 A MA50609 A MA 50609A MA 50609 A MA50609 A MA 50609A
- Authority
- MA
- Morocco
- Prior art keywords
- enantiomers
- antiviral compounds
- substituted thiazoles
- thiazoles used
- substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17195047 | 2017-10-05 | ||
| PCT/EP2018/077022 WO2019068817A1 (fr) | 2017-10-05 | 2018-10-04 | Énantiomères de thiazoles substitués utilisés comme composés antiviraux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA50609A true MA50609A (fr) | 2020-08-12 |
| MA50609B1 MA50609B1 (fr) | 2023-03-31 |
Family
ID=60022026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA50609A MA50609B1 (fr) | 2017-10-05 | 2018-10-04 | Énantiomères de thiazoles substitués utilisés comme composés antiviraux |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US11278534B2 (fr) |
| EP (2) | EP4209491A1 (fr) |
| JP (1) | JP7215689B2 (fr) |
| KR (1) | KR20200066619A (fr) |
| CN (1) | CN111433203B (fr) |
| AR (1) | AR113344A1 (fr) |
| AU (1) | AU2018344471B2 (fr) |
| BR (1) | BR112020006710A2 (fr) |
| CA (1) | CA3077397A1 (fr) |
| CL (1) | CL2020000869A1 (fr) |
| CR (1) | CR20200154A (fr) |
| DK (1) | DK3692039T3 (fr) |
| EA (1) | EA202090620A1 (fr) |
| EC (1) | ECSP20021132A (fr) |
| ES (1) | ES2939652T3 (fr) |
| FI (1) | FI3692039T3 (fr) |
| HR (1) | HRP20230158T1 (fr) |
| HU (1) | HUE061307T2 (fr) |
| IL (1) | IL273681A (fr) |
| JO (1) | JOP20200110A1 (fr) |
| LT (1) | LT3692039T (fr) |
| MA (1) | MA50609B1 (fr) |
| MD (1) | MD3692039T2 (fr) |
| MX (1) | MX2020003369A (fr) |
| NI (1) | NI202000025A (fr) |
| PH (1) | PH12020550132A1 (fr) |
| PL (1) | PL3692039T3 (fr) |
| PT (1) | PT3692039T (fr) |
| RS (1) | RS64000B1 (fr) |
| SG (1) | SG11202002420SA (fr) |
| SI (1) | SI3692039T1 (fr) |
| TW (1) | TWI706941B (fr) |
| UA (1) | UA126163C2 (fr) |
| UY (1) | UY37917A (fr) |
| WO (1) | WO2019068817A1 (fr) |
| ZA (1) | ZA202002150B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3692039T1 (sl) * | 2017-10-05 | 2023-04-28 | Innovative Molecules Gmbh | Enantomeri substituiranih tiazolov kot protivirusne spojine |
| WO2019168874A1 (fr) | 2018-02-27 | 2019-09-06 | The Research Foundation For The State University Of New York | Compositions de difluorométhoxylation et de trifluorométhoxylation et leurs procédés de synthèse |
| TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
| AU2021367976A1 (en) | 2020-10-29 | 2023-06-08 | Innovative Molecules Gmbh | Deuterated aminothiazole compounds as antiviral compounds |
| AU2023206628A1 (en) | 2022-01-17 | 2024-08-01 | Innovative Molecules Gmbh | Solid crystalline forms of helicase-primase inhibitors and process of preparation thereof |
| WO2024047508A1 (fr) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Compositions pharmaceutiques contre le virus de l'herpès |
| WO2024049760A1 (fr) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Composés de thiazolyl-urée cyclique pour le traitement du vhs |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7100497A (fr) | 1970-01-16 | 1971-07-20 | ||
| IL124436A0 (en) | 1995-12-29 | 1998-12-06 | Boehringer Ingelheim Phaarmace | Phenyl thiazole derivatives with anti herpes virus properties |
| US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| WO1999042455A1 (fr) | 1998-02-19 | 1999-08-26 | Tularik Inc. | Agents antiviraux |
| WO1999047507A2 (fr) | 1998-03-19 | 1999-09-23 | Pharmacia & Upjohn Company | 1,3,4-thiadiazoles utiles pour le traitement d'infections a cmv |
| DE19959958A1 (de) | 1999-12-13 | 2001-08-30 | Bayer Ag | Thiazolylharnstoff-Derivate |
| AU2914200A (en) | 1999-03-08 | 2000-09-28 | Bayer Aktiengesellschaft | Thiazolyl urea derivatives and their utilization as antiviral agents |
| DE19927415A1 (de) | 1999-06-16 | 2000-12-21 | Bayer Ag | Indolinylharnstoffderivate |
| DE10039265A1 (de) | 2000-08-11 | 2002-02-21 | Bayer Ag | Thiazolylamid-Derivate |
| DOP2000000109A (es) | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| CA2412720A1 (fr) | 2000-06-15 | 2001-12-20 | Bayer Aktiengesellschaft | Methodes d'identification de composes presentant une activite antiherpes |
| DE10038022A1 (de) | 2000-08-04 | 2002-02-14 | Bayer Ag | Inverse Thiazolylamid-Derivate |
| DE10044353A1 (de) | 2000-09-07 | 2002-04-04 | Bayer Ag | Unkompetitive Inhibitoren der Helikase-Primase |
| DE10044328A1 (de) | 2000-09-07 | 2002-03-21 | Bayer Ag | Thiazolylcarbonyl-Derivate |
| DE10044358A1 (de) | 2000-09-07 | 2002-03-21 | Bayer Ag | Thiazolylcarbonylheterocyclyl-Derivate |
| DE10129715A1 (de) * | 2001-06-22 | 2003-01-02 | Bayer Ag | Thiazolylamide |
| DE10129717A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Kombinationspräparate zur Herpes-Behandlung |
| DE10129714A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Topische Anwendung von Thiazolylamiden |
| DE10129716A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Kombinationspräparate zur Herpes-Behandlung |
| DE10131128A1 (de) | 2001-06-28 | 2003-01-16 | Bayer Ag | Sekundäre Sulfonamide |
| DE10210319A1 (de) | 2002-03-08 | 2003-09-18 | Bayer Ag | Thiazolylcarbonyl-Derivate |
| DE10235967B4 (de) | 2002-08-06 | 2005-09-08 | Bayer Healthcare Ag | Methode zum Identifizieren von Substanzen mit antimikrobieller Wirkung |
| DE10300109A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Methode zur Inhibition der Replikation von Herpesviren |
| EP3219709B1 (fr) | 2004-01-30 | 2020-03-18 | Vertex Pharmaceuticals Incorporated | Composé intermédiaire de modulateurs de transporteurs de cassette à liaison atp |
| DE102005014248A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
| ES2409734T3 (es) | 2006-12-08 | 2013-06-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Gorro de electrodos secos para electroencefalografía |
| DE102010046720A1 (de) | 2010-09-23 | 2012-03-29 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von pan-CDK-Inhibitoren der Formel (l), sowie Intermediate der Herstellung |
| JP5837936B2 (ja) * | 2010-11-01 | 2015-12-24 | ロマーク ラボラトリース，エル．シー． | アルキルスルフィニル置換チアゾリド化合物 |
| TWI555737B (zh) | 2011-05-24 | 2016-11-01 | 拜耳知識產權公司 | 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺 |
| EP2573086A1 (fr) | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | Monohydrate de mesylate acétamide N-[5-(Aminosulfonyl)-4-méthyl-1,3-thiazol-2-yl]-N-méthyl-2-[4-(2-pyridinyl)phényl] |
| PE20181804A1 (es) * | 2016-04-06 | 2018-11-19 | Innovative Molecules Gmbh | Derivados de aminotiazol utiles como agentes antiviricos |
| AU2017365632B2 (en) | 2016-11-28 | 2021-07-15 | Aicuris Gmbh & Co. Kg | N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide free base hemihydrate, methods of manufacture and uses thereof |
| TW201825095A (zh) | 2016-11-28 | 2018-07-16 | 德商艾庫里斯抗感染治療有限公司 | 包含n-[5-(胺基磺醯基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)-苯基]-乙醯胺之局部醫藥調配物 |
| PL3544977T3 (pl) | 2016-11-28 | 2021-11-08 | Aicuris Gmbh & Co. Kg | Sól maleinianowa wolnej zasady n-[5-(aminosulfonylo)-4-metylo-1,3-tiazol-2-ilo]-n-metylo-2-[4-(2-pirydynylo)fe¬nylo]acetamidu, preparaty farmaceutyczne, sposoby wytwarzania oraz ich zastosowania do leczenia wirusa opryszczki |
| EP3566749A4 (fr) | 2017-01-09 | 2020-09-23 | Medshine Discovery Inc. | Dérivé thiazole et utilisations de ce dernier |
| SI3692039T1 (sl) * | 2017-10-05 | 2023-04-28 | Innovative Molecules Gmbh | Enantomeri substituiranih tiazolov kot protivirusne spojine |
-
2018
- 2018-10-04 SI SI201830861T patent/SI3692039T1/sl unknown
- 2018-10-04 ES ES18779696T patent/ES2939652T3/es active Active
- 2018-10-04 EP EP22213253.2A patent/EP4209491A1/fr active Pending
- 2018-10-04 UY UY0001037917A patent/UY37917A/es unknown
- 2018-10-04 HU HUE18779696A patent/HUE061307T2/hu unknown
- 2018-10-04 MD MDE20200816T patent/MD3692039T2/ro unknown
- 2018-10-04 MA MA50609A patent/MA50609B1/fr unknown
- 2018-10-04 CA CA3077397A patent/CA3077397A1/fr active Pending
- 2018-10-04 FI FIEP18779696.6T patent/FI3692039T3/fi active
- 2018-10-04 KR KR1020207009294A patent/KR20200066619A/ko not_active Application Discontinuation
- 2018-10-04 UA UAA202002635A patent/UA126163C2/uk unknown
- 2018-10-04 EP EP18779696.6A patent/EP3692039B1/fr active Active
- 2018-10-04 US US16/753,814 patent/US11278534B2/en active Active
- 2018-10-04 AR ARP180102864A patent/AR113344A1/es unknown
- 2018-10-04 LT LTEPPCT/EP2018/077022T patent/LT3692039T/lt unknown
- 2018-10-04 MX MX2020003369A patent/MX2020003369A/es unknown
- 2018-10-04 PL PL18779696.6T patent/PL3692039T3/pl unknown
- 2018-10-04 DK DK18779696.6T patent/DK3692039T3/da active
- 2018-10-04 SG SG11202002420SA patent/SG11202002420SA/en unknown
- 2018-10-04 RS RS20230156A patent/RS64000B1/sr unknown
- 2018-10-04 CR CR20200154A patent/CR20200154A/es unknown
- 2018-10-04 BR BR112020006710A patent/BR112020006710A2/pt unknown
- 2018-10-04 TW TW107135101A patent/TWI706941B/zh active
- 2018-10-04 EA EA202090620A patent/EA202090620A1/ru unknown
- 2018-10-04 WO PCT/EP2018/077022 patent/WO2019068817A1/fr active Application Filing
- 2018-10-04 PT PT187796966T patent/PT3692039T/pt unknown
- 2018-10-04 HR HRP20230158TT patent/HRP20230158T1/hr unknown
- 2018-10-04 AU AU2018344471A patent/AU2018344471B2/en active Active
- 2018-10-04 CN CN201880065255.2A patent/CN111433203B/zh active Active
- 2018-10-04 JP JP2020519403A patent/JP7215689B2/ja active Active
- 2018-10-04 JO JOP/2020/0110A patent/JOP20200110A1/ar unknown
-
2020
- 2020-03-25 PH PH12020550132A patent/PH12020550132A1/en unknown
- 2020-03-29 IL IL273681A patent/IL273681A/en unknown
- 2020-04-01 NI NI202000025A patent/NI202000025A/es unknown
- 2020-04-01 CL CL2020000869A patent/CL2020000869A1/es unknown
- 2020-04-03 EC ECSENADI202021132A patent/ECSP20021132A/es unknown
- 2020-05-04 ZA ZA2020/02150A patent/ZA202002150B/en unknown
-
2022
- 2022-01-21 US US17/581,166 patent/US20220152008A1/en active Pending
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