MA41677A - Composés alpha-cinnamide et compositions comme inhibiteurs de hdac8 - Google Patents

Composés alpha-cinnamide et compositions comme inhibiteurs de hdac8

Info

Publication number
MA41677A
MA41677A MA041677A MA41677A MA41677A MA 41677 A MA41677 A MA 41677A MA 041677 A MA041677 A MA 041677A MA 41677 A MA41677 A MA 41677A MA 41677 A MA41677 A MA 41677A
Authority
MA
Morocco
Prior art keywords
alpha
compositions
hdac8 inhibitors
cinnamide compounds
cinnamide
Prior art date
Application number
MA041677A
Other languages
English (en)
Inventor
Kenneth W Bair
Nicholas Barczak
Bingsong Han
David R Lancia Jr
Cuixian Liu
Matthew W Martin
Pui Yee Ng
Aleksandra Rudnitskaya
Jennifer R Thomason
Mary-Margaret Zablocki
Xiaozhang Zheng
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MA41677A publication Critical patent/MA41677A/fr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035Isoindoles, e.g. phthalimide
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/53751,4-Oxazines, e.g. morpholine
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US10988441B2 (en) 2021-04-27
CA2979391C (fr) 2023-10-17
AU2016233568A1 (en) 2017-10-05
BR112017019453A2 (pt) 2018-05-15
EP3932914A1 (fr) 2022-01-05
US11919839B2 (en) 2024-03-05
US20220073452A1 (en) 2022-03-10
KR20170124602A (ko) 2017-11-10
US20180297939A1 (en) 2018-10-18
MX2017011778A (es) 2017-12-04
US10266487B2 (en) 2019-04-23
US10508077B2 (en) 2019-12-17
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HK1249104A1 (zh) 2018-10-26
IL254383A0 (en) 2017-11-30
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US20200331847A1 (en) 2020-10-22
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TW201639811A (zh) 2016-11-16
US9745253B2 (en) 2017-08-29
CR20170420A (es) 2017-10-03
US20160264518A1 (en) 2016-09-15
CA2979391A1 (fr) 2016-09-22
ECSP17064695A (es) 2017-10-31
WO2016149099A1 (fr) 2016-09-22
PE20171517A1 (es) 2017-10-20
JP2018531213A (ja) 2018-10-25
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US20190241506A1 (en) 2019-08-08
US20180044282A1 (en) 2018-02-15

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