DE60037836D1 - ThiazoloÄ4,5-dÜpyrimidinverbindungen zur Behandlung von rheumathoider Arthritis - Google Patents

ThiazoloÄ4,5-dÜpyrimidinverbindungen zur Behandlung von rheumathoider Arthritis

Info

Publication number
DE60037836D1
DE60037836D1 DE60037836T DE60037836T DE60037836D1 DE 60037836 D1 DE60037836 D1 DE 60037836D1 DE 60037836 T DE60037836 T DE 60037836T DE 60037836 T DE60037836 T DE 60037836T DE 60037836 D1 DE60037836 D1 DE 60037836D1
Authority
DE
Germany
Prior art keywords
compounds
diphyrimidine
treatment
rheumatoid arthritis
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60037836T
Other languages
English (en)
Other versions
DE60037836T2 (de
Inventor
Roger Bonnert
Simon Fraser Hunt
Paul Willis
Iain Walthers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
AstraZeneca UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd
Application granted granted Critical
Publication of DE60037836D1 publication Critical patent/DE60037836D1/de
Publication of DE60037836T2 publication Critical patent/DE60037836T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60037836T 1999-10-01 2000-09-26 ThiazoloÄ4,5-dÜpyrimidinverbindungen zur Behandlung von rheumathoider Arthritis Expired - Lifetime DE60037836T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903544A SE9903544D0 (sv) 1999-10-01 1999-10-01 Novel compounds
SE9903544 1999-10-01

Publications (2)

Publication Number Publication Date
DE60037836D1 true DE60037836D1 (de) 2008-03-06
DE60037836T2 DE60037836T2 (de) 2009-01-15

Family

ID=20417218

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60037836T Expired - Lifetime DE60037836T2 (de) 1999-10-01 2000-09-26 ThiazoloÄ4,5-dÜpyrimidinverbindungen zur Behandlung von rheumathoider Arthritis
DE60007768T Expired - Lifetime DE60007768T2 (de) 1999-10-01 2000-09-26 Neue thiazolo(4,5-d)pyrimidinverbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60007768T Expired - Lifetime DE60007768T2 (de) 1999-10-01 2000-09-26 Neue thiazolo(4,5-d)pyrimidinverbindungen

Country Status (27)

Country Link
US (3) US6790850B1 (de)
EP (2) EP1222195B1 (de)
JP (1) JP4824889B2 (de)
KR (1) KR100765051B1 (de)
CN (1) CN1210279C (de)
AT (2) ATE384068T1 (de)
AU (1) AU777872B2 (de)
BR (1) BR0014334A (de)
CA (1) CA2385269C (de)
CZ (1) CZ20021113A3 (de)
DE (2) DE60037836T2 (de)
DK (1) DK1222195T3 (de)
EE (1) EE05037B1 (de)
ES (2) ES2298451T3 (de)
HK (1) HK1052009A1 (de)
HU (1) HUP0204246A3 (de)
IL (2) IL148910A0 (de)
IS (1) IS2229B (de)
MX (1) MXPA02003263A (de)
NO (1) NO327706B1 (de)
NZ (1) NZ517880A (de)
PT (1) PT1222195E (de)
SE (1) SE9903544D0 (de)
TW (1) TWI260324B (de)
UA (1) UA73521C2 (de)
WO (1) WO2001025242A1 (de)
ZA (1) ZA200202380B (de)

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GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
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GB0221828D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
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UA90707C2 (en) 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
TW200820973A (en) 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
AR071036A1 (es) * 2008-03-26 2010-05-19 Astrazeneca Ab Derivados 5, 7-disustituidos de [1, 3]tiazolo[4, 5-d]pirimidin-2 (3h)-ona, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor cx3cr1.
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
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US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
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JP2008524186A (ja) 2004-12-17 2008-07-10 アストラゼネカ・アクチエボラーグ ケモカイン受容体活性の調節のためのチアゾロピラミジン化合物

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EP1348709B1 (de) 2008-01-16
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IL148910A0 (en) 2002-09-12
EP1222195B1 (de) 2004-01-14
EE200200174A (et) 2003-04-15
CN1402730A (zh) 2003-03-12
TWI260324B (en) 2006-08-21
IL148910A (en) 2006-10-31
CA2385269C (en) 2010-08-17
EP1348709A2 (de) 2003-10-01
ES2213043T3 (es) 2004-08-16
EP1222195A1 (de) 2002-07-17
ATE384068T1 (de) 2008-02-15
EE05037B1 (et) 2008-06-16
NO327706B1 (no) 2009-09-14
PT1222195E (pt) 2004-05-31
DE60037836T2 (de) 2009-01-15
NO20021448D0 (no) 2002-03-22
IS2229B (is) 2007-04-15
ZA200202380B (en) 2003-10-29
ATE257838T1 (de) 2004-01-15
CA2385269A1 (en) 2001-04-12
US20090281123A1 (en) 2009-11-12
NZ517880A (en) 2003-09-26
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US6790850B1 (en) 2004-09-14
AU777872B2 (en) 2004-11-04
DE60007768D1 (de) 2004-02-19
BR0014334A (pt) 2002-06-11
HK1052009A1 (en) 2003-08-29
JP4824889B2 (ja) 2011-11-30
CN1210279C (zh) 2005-07-13
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US20040224961A1 (en) 2004-11-11
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HUP0204246A2 (hu) 2003-04-28
EP1348709A3 (de) 2003-11-19
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IS6306A (is) 2002-03-18
UA73521C2 (en) 2005-08-15
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8381 Inventor (new situation)

Inventor name: BONNERT, ROGER, LOUGHBOROUGH, LEICS LE11 5RH, GB

Inventor name: HUNT, SIMON FRASER, LOUGHBOROUGH, LEICS LE11 5, GB

Inventor name: WILLIS, PAUL, LOUGHBOROUGH, LEICS LE11 5RH, GB

Inventor name: WALTHERS, IAIN, LOUGHBOROUGH, LEICS LE11 5RH, GB

8364 No opposition during term of opposition