DE60202942D1 - Thiazolopyrimidine und deren verwendung als modulatoren der chemokinrezeptoraktivität - Google Patents
Thiazolopyrimidine und deren verwendung als modulatoren der chemokinrezeptoraktivitätInfo
- Publication number
- DE60202942D1 DE60202942D1 DE60202942T DE60202942T DE60202942D1 DE 60202942 D1 DE60202942 D1 DE 60202942D1 DE 60202942 T DE60202942 T DE 60202942T DE 60202942 T DE60202942 T DE 60202942T DE 60202942 D1 DE60202942 D1 DE 60202942D1
- Authority
- DE
- Germany
- Prior art keywords
- thiazolopyrimidines
- modulators
- receptor activity
- chemokin receptor
- chemokin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0101322 | 2001-04-12 | ||
SE0101322A SE0101322D0 (sv) | 2001-04-12 | 2001-04-12 | Novel compounds |
PCT/SE2002/000731 WO2002083693A1 (en) | 2001-04-12 | 2002-04-12 | Thiazolopyrimidines and their use as modulators of chemokine receptor activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60202942D1 true DE60202942D1 (de) | 2005-03-17 |
DE60202942T2 DE60202942T2 (de) | 2006-08-31 |
Family
ID=20283779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60202942T Expired - Fee Related DE60202942T2 (de) | 2001-04-12 | 2002-04-12 | Thiazolopyrimidine und deren verwendung als modulatoren der chemokinrezeptoraktivität |
Country Status (7)
Country | Link |
---|---|
US (2) | US6949643B2 (de) |
EP (1) | EP1385854B1 (de) |
JP (1) | JP2004525972A (de) |
AT (1) | ATE288919T1 (de) |
DE (1) | DE60202942T2 (de) |
SE (1) | SE0101322D0 (de) |
WO (1) | WO2002083693A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
GB2359081A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
GB2359078A (en) * | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
SE0003828D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Novel compounds |
SE0102716D0 (sv) * | 2001-08-14 | 2001-08-14 | Astrazeneca Ab | Novel compounds |
AU2003246972A1 (en) | 2002-08-06 | 2004-02-23 | Astrazeneca Ab | Condensed pyridines and pyrimidines with tie2 (tek) activity |
GB0221829D0 (en) * | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
GB0221828D0 (en) * | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
WO2004074260A1 (ja) * | 2003-02-21 | 2004-09-02 | Kyowa Hakko Kogyo Co., Ltd. | ピリミジン誘導体 |
EP1675862A1 (de) * | 2003-10-07 | 2006-07-05 | AstraZeneca AB | Neue, als antagonisten von chemokinrezeptoren, insbesondere cx3cr1, geeignete 2-substituierte 4-aminothiazolo[4,5-d] pyrimidine |
GB0328243D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Methods |
SE528366C2 (sv) * | 2004-02-13 | 2006-10-31 | Sectra Mamea Ab | Metod och anordning avseende röntgenbildtagning |
UA90707C2 (en) | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
AR053347A1 (es) | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
AR071036A1 (es) * | 2008-03-26 | 2010-05-19 | Astrazeneca Ab | Derivados 5, 7-disustituidos de [1, 3]tiazolo[4, 5-d]pirimidin-2 (3h)-ona, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor cx3cr1. |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2924472A (en) * | 1957-06-27 | 1960-02-09 | Gen Motors Corp | Pipe joint seal |
US3318900A (en) * | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
BE668603A (de) * | 1964-08-20 | |||
DE2331223C2 (de) | 1972-06-19 | 1984-11-22 | Kohjin Co., Ltd., Tokio / Tokyo | S-substituierte-2-Thioadenosine, deren 5'-Monophosphate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten |
JPS5188994A (en) | 1975-02-04 | 1976-08-04 | Shinkijichikan 88 aminoadeninjudotainoseizoho | |
US4120521A (en) * | 1975-08-28 | 1978-10-17 | Rieber & Son Plastic-Industri A/S | Combined mould element and sealing ring |
EG12406A (en) * | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
GB1600293A (en) * | 1977-02-04 | 1981-10-14 | British Oceanics Ltd | Sealing arrangements |
US4188040A (en) * | 1977-04-06 | 1980-02-12 | Firma WOCO Franz-Josef Wolf & Co. | Sealing ring |
DE2726959A1 (de) * | 1977-06-15 | 1979-01-18 | Arlt Christian | Dichteinsatz zum dichten verbinden von zwei rohren |
FR2421899A1 (fr) * | 1978-01-16 | 1979-11-02 | Roussel Uclaf | Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits |
US4410528A (en) * | 1980-05-16 | 1983-10-18 | Kyowa Hakko Kogyo Co., Ltd. | Hypotensive piperidine derivatives |
DE3219522A1 (de) * | 1981-10-28 | 1983-12-01 | Denso-Chemie Wedekind Kg, 5090 Leverkusen | Steckmuffendichtung fuer rohre |
FR2547888B1 (fr) * | 1983-06-22 | 1985-12-13 | Sabla Sa | Bague d'etancheite a implants pour tuyaux a emboitement |
CA1338012C (en) | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
SE8800348L (sv) * | 1988-02-03 | 1989-08-04 | Forsheda Ab | Taetningsring och verktyg foer framstaellning daerav |
FR2659656B1 (fr) | 1990-03-15 | 1994-09-09 | Sanofi Sa | Derives de pyrimidinedione-2,4 et medicaments les contenant. |
DE4119767A1 (de) | 1991-06-15 | 1992-12-17 | Dresden Arzneimittel | Verfahren zur herstellung von (pyrimid-2-yl-thio- bzw. seleno)-essigsaeurederivaten |
US5169161A (en) * | 1991-09-19 | 1992-12-08 | Hail Mary Rubber Co., Inc. | Symmetrical gasket for pipe joints |
DE4134089C2 (de) * | 1991-10-15 | 1994-10-13 | Dueker Eisenwerk | Schubgesicherte Muffenverbindung |
DE4229609C2 (de) * | 1992-09-04 | 2003-05-08 | Forsheda Stefa Gmbh | Abdichtung zwischen zwei ineinandersteckbaren Teilen |
US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
DK0778277T3 (da) | 1995-12-08 | 2003-10-27 | Pfizer | Substituerede heterocycliske derivater som CRF antagonister |
SE515033C2 (sv) * | 1995-12-27 | 2001-06-05 | Forsheda Ab | Tätningsanordning |
US6180649B1 (en) | 1996-04-19 | 2001-01-30 | Nerosearch A/S | 1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
EP0923582B1 (de) | 1996-08-28 | 2006-09-20 | Pfizer Inc. | Substituierte 6,5-heterobicyclische-derivate |
AU5522498A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
EP1003514A4 (de) | 1997-07-25 | 2000-10-11 | Merck & Co Inc | Cyclische amine modulatoren der chemokinrezeptoren |
AR013669A1 (es) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
US6329381B1 (en) * | 1997-11-28 | 2001-12-11 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds |
AU1679099A (en) | 1998-01-19 | 1999-08-02 | Pfizer Inc. | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists |
US6407121B1 (en) * | 1998-03-19 | 2002-06-18 | Nihon Nohyaku Co., Ltd. | Arylpiperidine derivatives and use thereof |
AU3213699A (en) | 1998-04-03 | 1999-10-25 | Du Pont Pharmaceuticals Company | Thiazolo(4,5-d)pyrimidines and pyridines as corticotropin releasing factor (CRF)antagonists |
MA26659A1 (fr) * | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
SE9802729D0 (sv) | 1998-08-13 | 1998-08-13 | Astra Pharma Prod | Novel Compounds |
US5988695A (en) * | 1998-08-26 | 1999-11-23 | S&B Technical Products, Inc. | Pipe gasket with embedded ring |
PE20001420A1 (es) | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
ATE277929T1 (de) | 1998-12-28 | 2004-10-15 | 4 Aza Bioscience Nv | Immunsuppressive wirkungen von pteridinderivaten |
CA2361561A1 (en) | 1999-02-02 | 2000-08-10 | K.U. Leuven Research & Development | Immunosurpressive effects of pteridine derivatives |
US6248755B1 (en) * | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
US6142484A (en) * | 1999-04-15 | 2000-11-07 | Vassallo Research & Development Corporation | Composite multi-pressure gasket |
AU5600100A (en) * | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
US6340681B1 (en) | 1999-07-16 | 2002-01-22 | Pfizer Inc | 2-benzimidazolylamine compounds as ORL-1-receptor agonists |
SK3542002A3 (en) * | 1999-09-15 | 2003-04-01 | Warner Lambert Co | Pteridinones as kinase inhibitors |
PE20010628A1 (es) | 1999-10-01 | 2001-06-18 | Takeda Chemical Industries Ltd | Compuestos de amina ciclica, su produccion y su uso |
SE9903544D0 (sv) * | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
DE60023100T2 (de) | 2000-01-05 | 2006-07-06 | Pfizer Inc. | Benzimidazol-Verbindungen zur Verwendung als ORL1-Rezeptor-Antagonisten |
AU2001232556A1 (en) | 2000-02-11 | 2001-08-20 | Astrazeneca Ab | Pyrimidine compounds and their use as modulators of chemokine receptor activity |
GB2359078A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
GB2359081A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
GB2359079A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
GB2359551A (en) * | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
US6790854B2 (en) * | 2000-03-24 | 2004-09-14 | Meiji Seika Kaisha, Ltd. | Diphenylalkylamine derivatives useful as opioid receptor agonists |
SE0102716D0 (sv) | 2001-08-14 | 2001-08-14 | Astrazeneca Ab | Novel compounds |
-
2001
- 2001-04-12 SE SE0101322A patent/SE0101322D0/xx unknown
-
2002
- 2002-04-12 AT AT02724837T patent/ATE288919T1/de not_active IP Right Cessation
- 2002-04-12 EP EP02724837A patent/EP1385854B1/de not_active Expired - Lifetime
- 2002-04-12 WO PCT/SE2002/000731 patent/WO2002083693A1/en active IP Right Grant
- 2002-04-12 DE DE60202942T patent/DE60202942T2/de not_active Expired - Fee Related
- 2002-04-12 US US10/474,610 patent/US6949643B2/en not_active Expired - Fee Related
- 2002-04-12 JP JP2002581448A patent/JP2004525972A/ja active Pending
-
2005
- 2005-09-12 US US11/225,379 patent/US20060111569A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040157853A1 (en) | 2004-08-12 |
DE60202942T2 (de) | 2006-08-31 |
SE0101322D0 (sv) | 2001-04-12 |
ATE288919T1 (de) | 2005-02-15 |
US20060111569A1 (en) | 2006-05-25 |
JP2004525972A (ja) | 2004-08-26 |
US6949643B2 (en) | 2005-09-27 |
EP1385854A1 (de) | 2004-02-04 |
WO2002083693A1 (en) | 2002-10-24 |
EP1385854B1 (de) | 2005-02-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de | ||
8370 | Indication related to discontinuation of the patent is to be deleted | ||
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |