NL1025148A1 - Benzamideremmers van de P2X7-receptor. - Google Patents

Benzamideremmers van de P2X7-receptor.

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Publication number
NL1025148A1
NL1025148A1 NL1025148A NL1025148A NL1025148A1 NL 1025148 A1 NL1025148 A1 NL 1025148A1 NL 1025148 A NL1025148 A NL 1025148A NL 1025148 A NL1025148 A NL 1025148A NL 1025148 A1 NL1025148 A1 NL 1025148A1
Authority
NL
Netherlands
Prior art keywords
receptor
benzamide inhibitors
benzamide
inhibitors
Prior art date
Application number
NL1025148A
Other languages
English (en)
Other versions
NL1025148C2 (nl
Inventor
Mark Anthony Dombroski
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NL1025148A1 publication Critical patent/NL1025148A1/nl
Application granted granted Critical
Publication of NL1025148C2 publication Critical patent/NL1025148C2/nl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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NL1025148A 2002-12-31 2003-12-30 Benzamideremmers van de P2X7-receptor. NL1025148C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43750502P 2002-12-31 2002-12-31
US43750502 2002-12-31

Publications (2)

Publication Number Publication Date
NL1025148A1 true NL1025148A1 (nl) 2004-07-01
NL1025148C2 NL1025148C2 (nl) 2007-09-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NL1025148A NL1025148C2 (nl) 2002-12-31 2003-12-30 Benzamideremmers van de P2X7-receptor.

Country Status (40)

Country Link
US (4) US6974812B2 (nl)
EP (1) EP1581232B1 (nl)
JP (1) JP4560411B2 (nl)
KR (1) KR100689138B1 (nl)
CN (1) CN1732006A (nl)
AP (1) AP1997A (nl)
AR (1) AR042673A1 (nl)
AU (1) AU2003285716B2 (nl)
BR (1) BR0317803A (nl)
CA (1) CA2512193C (nl)
CL (1) CL2003002765A1 (nl)
CO (1) CO5580749A2 (nl)
CR (1) CR7884A (nl)
DO (1) DOP2003000790A (nl)
EA (1) EA008591B1 (nl)
EC (1) ECSP055884A (nl)
ES (1) ES2464350T3 (nl)
GE (1) GEP20084304B (nl)
GT (1) GT200300297A (nl)
HR (1) HRP20050609A2 (nl)
IL (2) IL168513A (nl)
IS (1) IS7840A (nl)
MA (1) MA27575A1 (nl)
MX (1) MXPA05006749A (nl)
MY (1) MY141984A (nl)
NI (1) NI200500118A (nl)
NL (1) NL1025148C2 (nl)
NO (1) NO20053587L (nl)
NZ (1) NZ539913A (nl)
OA (1) OA12978A (nl)
PA (1) PA8591801A1 (nl)
PE (1) PE20040802A1 (nl)
PL (1) PL378251A1 (nl)
RS (1) RS20050490A (nl)
TN (1) TNSN05174A1 (nl)
TW (1) TWI288133B (nl)
UA (1) UA82346C2 (nl)
UY (1) UY28153A1 (nl)
WO (1) WO2004058270A1 (nl)
ZA (1) ZA200503912B (nl)

Families Citing this family (62)

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US7071223B1 (en) * 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
EP1837330B1 (en) * 2003-05-12 2012-10-24 Pfizer Products Inc. Benzamide inhibitors of the P2X7 receptor
WO2004099146A1 (en) * 2003-05-12 2004-11-18 Pfizer Products Inc. Benzamide inhibitors of the p2x7 receptor
BRPI0512781A (pt) 2004-06-29 2008-04-08 Pfizer Prod Inc método para preparação de derivados de 5-{4-(2-hidroxi-propil)-3,5-dioxo-4,5-diidro-3h-[1,2,4]tria zin-2-il}-benzamida através da desproteção dos precursores de protetores de hidroxila
WO2006003513A1 (en) * 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3h-`1,2,4!-triazin-2-yl!benzamide derivatives with p2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid
EP1763353A1 (en) * 2004-06-29 2007-03-21 Warner-Lambert Company LLC COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X<sb>7</sb> RECEPTOR
SA05260265A (ar) * 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
WO2006083214A1 (en) * 2005-02-02 2006-08-10 Astrazeneca Ab Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor
CA2625940A1 (en) * 2005-08-29 2007-03-08 Irma Bernatchez-Lemaire Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents
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MX2011010810A (es) 2009-04-14 2012-01-12 Affectis Pharmaceuticals Ag Nuevos antagonistas de p2x7r y su uso.
US20130195919A1 (en) 2010-03-05 2013-08-01 President And Fellows Of Harvard College Induced dendritic cell compositions and uses thereof
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