UA99699C2 - Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит - Google Patents

Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит

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Publication number
UA99699C2
UA99699C2 UAA200714940A UAA200714940A UA99699C2 UA 99699 C2 UA99699 C2 UA 99699C2 UA A200714940 A UAA200714940 A UA A200714940A UA A200714940 A UAA200714940 A UA A200714940A UA 99699 C2 UA99699 C2 UA 99699C2
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UA
Ukraine
Prior art keywords
compound
pharmaceutical composition
directed
ikk2
carboxamide derivatives
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UAA200714940A
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English (en)
Ukrainian (uk)
Inventor
Жианг Денг
Джеффри К. Кернс
Ки Жин
Гуолианг Лин
Сишень Лин
Майкл Линденмус
Кристофер Э. Неипп
Хонг НИЕ
Соня М. Томас
Катрин Л. Виддоусон
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Смитклайн Бичам Корпорейшн
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Publication of UA99699C2 publication Critical patent/UA99699C2/ru

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Abstract

Изобретение касается производных индолкарбоксамида, в частности изобретений формулы I:(I),где R1, R2, R3, U и V определены в описании, а также их фармацевтически приемлемых солей.Соединения согласно изобретению являются ингибиторами IKK2 и могут быть использованы при лечении нарушений, связанных с аномальной активностью IKK2 (также известной как IKK), таких как ревматоидный артрит, астма и COPD (хроническое обструктивное заболевание легких). Изобретение также касается фармацевтических композиций, которые содержат соединение согласно изобретению, способов ингибирования активности IKK2 и лечения связанных с ней нарушений с использованием соединения согласно изобретению или фармацевтической композиции, которая содержит соединение согласно изобретению.
UAA200714940A 2005-06-30 2006-06-28 Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит UA99699C2 (ru)

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US69525605P 2005-06-30 2005-06-30

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UA99699C2 true UA99699C2 (ru) 2012-09-25

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EP (1) EP1896014A4 (ru)
JP (1) JP5059756B2 (ru)
KR (1) KR20080021077A (ru)
CN (1) CN101247804B (ru)
AR (1) AR055343A1 (ru)
AU (1) AU2006266028B2 (ru)
BR (1) BRPI0611674A2 (ru)
CA (1) CA2613068A1 (ru)
EA (1) EA014083B1 (ru)
IL (1) IL187786A0 (ru)
MA (1) MA29566B1 (ru)
MX (1) MX2007016541A (ru)
NO (1) NO20080457L (ru)
NZ (1) NZ563687A (ru)
PE (1) PE20070173A1 (ru)
TW (1) TWI380973B (ru)
UA (1) UA99699C2 (ru)
WO (1) WO2007005534A2 (ru)
ZA (1) ZA200709948B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
TW200626142A (en) 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
GB0525164D0 (en) * 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
WO2007076286A2 (en) * 2005-12-16 2007-07-05 Smithkline Beecham Corporation Chemical compounds
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
EP2370407B1 (en) * 2008-12-19 2014-06-18 Bristol-Myers Squibb Company Carbazole and carboline kinase inhibitors
JP2012520257A (ja) * 2009-03-10 2012-09-06 グラクソ グループ リミテッド Ｉｋｋ２阻害剤としてのインドール誘導体
LT3013337T (lt) * 2013-06-26 2019-01-10 Abbvie Inc. Pirminiai karboksamidai kaip btk inhibitoriai
RS60312B1 (sr) * 2014-10-24 2020-07-31 Bristol Myers Squibb Co Jedinjenja indol karboksamida korisna kao inhibitori kinaze

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200000291T2 (tr) * 1997-08-06 2000-07-21 Eli Lilly And Company Taşikinin reseptör antagonistleri olarak 2-asilaminopropanaminler.
DE19807993A1 (de) 1998-02-26 1999-09-02 Bayer Ag Verwendung von ß-Carbolinderivaten zur Bekämpfung von TNF-alpha-abhängigen Krankheiten
CA2377085C (en) 1999-06-23 2011-02-15 Aventis Pharma Deutschland Gmbh Substituted benzimidazoles
DE19928424A1 (de) 1999-06-23 2000-12-28 Aventis Pharma Gmbh Substituierte Benzimidazole
DE19951360A1 (de) 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
GB0003154D0 (en) 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
EP1268477B1 (en) 2000-03-15 2010-04-21 Sanofi-Aventis Deutschland GmbH Substituted beta-carbolines with ikb-kinase inhibiting activity
EP1209158A1 (en) 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
EP1134221A1 (en) 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
JP2001278886A (ja) * 2000-03-28 2001-10-10 Dai Ichi Seiyaku Co Ltd ベンゾオキサジン誘導体及びこれを含有する医薬
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
JP4272338B2 (ja) 2000-09-22 2009-06-03 バイエル アクチェンゲゼルシャフト ピリジン誘導体
US6869956B2 (en) 2000-10-03 2005-03-22 Bristol-Myers Squibb Company Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)
ES2260300T3 (es) 2000-10-03 2006-11-01 Bristol-Myers Squibb Company Compuestos tetraciclicos sustituidos con amino utiles como agentes antiinflamatorios y composiciones farmaceuticas que comprenden los mismos.
EP1328272A1 (en) 2000-10-12 2003-07-23 SmithKline Beecham Corporation Nf-kappa-b inhibitors
JP2004523476A (ja) 2000-10-12 2004-08-05 スミスクライン・ビーチャム・コーポレイション ＮＦ−κＢ阻害剤
DE60133758T2 (de) 2000-10-26 2009-07-02 Amgen Inc., Thousand Oaks Antiphlogistische mittel
JP2002193938A (ja) 2000-12-01 2002-07-10 Bayer Ag ４−アリールピリジン誘導体
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
WO2002060386A2 (en) 2001-02-01 2002-08-08 Bristol-Myers Squibb Company METHODS OF TREATING INFLAMMATORY AND IMMUNE DISEASES USING INHIBITORS OF IλB KINASE (IKK)
WO2002094265A1 (en) 2001-05-24 2002-11-28 Leo Pharma A/S A method of modulating nf-$g(k)b activity
CZ20033190A3 (cs) 2001-05-24 2004-06-16 Leo Pharma A/S Nové pyridylkyanoguanidinové sloučeniny
US20030045515A1 (en) 2001-05-24 2003-03-06 Lise Binderup Combination medicament for treatment of neoplastic diseases
US6638679B2 (en) 2001-07-12 2003-10-28 Kodak Polychrome Graphics, Llc Photosensitive compositions having mixtures of alkoxy and non-alkoxy diazonium salt containing compounds
SE0102616D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
SE0102617D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
WO2003024936A1 (en) 2001-09-19 2003-03-27 Pharmacia Corporation Substituted pyrazolo compounds for the treatment of inflammation
MXPA04002683A (es) 2001-09-19 2004-06-18 Pharmacia Corp Compuestos bencenosulfamida pirazolil sustituidos para el tratamiento de la inflamacion.
AU2002341729A1 (en) 2001-09-19 2003-04-01 Pharmacia Corporation Substituted pyrazolyl compounds for the treatment of inflammation
US20030109550A1 (en) 2001-09-19 2003-06-12 Michael Clare Substituted indazole compounds for the treatment of inflammation
MXPA04004064A (es) 2001-10-30 2004-09-06 Pharmacia Corp Derivados heteroaromaticos de carboxamida para el tratramiento de la inflamacion.
DE60315615T2 (de) 2002-04-03 2008-10-02 Bristol-Myers Squibb Co. Tricyclische verbindungen basierend auf thiophen und arzneimittel, die diese umfassen
WO2003095430A1 (en) 2002-05-09 2003-11-20 Pharmacia Corporation Substituted pyrazolyl compounds for the treatment of inflammation
AU2003237330A1 (en) 2002-06-06 2003-12-22 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
GB0217757D0 (en) * 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
CA2494962C (en) * 2002-08-09 2011-06-14 Merck & Co., Inc. Tyrosine kinase inhibitors
DE10237722A1 (de) 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
WO2004075846A2 (en) 2003-02-25 2004-09-10 Bristol-Myers Squibb Company Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
CA2534127A1 (en) 2003-07-31 2005-02-10 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzothiophene compounds and uses thereof
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7291733B2 (en) 2003-10-10 2007-11-06 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted tricyclic heterocycles and their uses
MXPA06003746A (es) 2003-10-14 2006-06-14 Pharmacia Corp Compuestos de pirazinona sustituida para el tratamiento de inflamacion.
GB0400895D0 (en) * 2004-01-15 2004-02-18 Smithkline Beecham Corp Chemical compounds
PE20060373A1 (es) * 2004-06-24 2006-04-29 Smithkline Beecham Corp Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2
TW200626142A (en) * 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
CN101060842A (zh) * 2004-09-21 2007-10-24 葛兰素集团有限公司 化合物

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AR055343A1 (es) 2007-08-22
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