MX2009013169A - Benzamide mglur5 positive allosteric modulators and methods of making and using same. - Google Patents
Benzamide mglur5 positive allosteric modulators and methods of making and using same.Info
- Publication number
- MX2009013169A MX2009013169A MX2009013169A MX2009013169A MX2009013169A MX 2009013169 A MX2009013169 A MX 2009013169A MX 2009013169 A MX2009013169 A MX 2009013169A MX 2009013169 A MX2009013169 A MX 2009013169A MX 2009013169 A MX2009013169 A MX 2009013169A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compounds
- making
- positive allosteric
- allosteric modulators
- Prior art date
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract
In one aspect, the invention relates to compounds, including benzamide derivatives and cyclic benzamide derivatives, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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PCT/US2008/065647 WO2008151184A1 (en) | 2007-06-03 | 2008-06-03 | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
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EP (1) | EP2162136A4 (en) |
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CN (1) | CN101795689B (en) |
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Families Citing this family (71)
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SG177221A1 (en) | 2006-12-15 | 2012-01-30 | Abbott Lab | Novel oxadiazole compounds |
US8853392B2 (en) | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
US8034806B2 (en) | 2007-11-02 | 2011-10-11 | Vanderbilt University | Bicyclic mGluR5 positive allosteric modulators and methods of making and using same |
GB0811643D0 (en) | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
TW201028421A (en) * | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
US8389536B2 (en) * | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
US8586581B2 (en) | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
EP2513118B1 (en) | 2009-12-18 | 2013-09-18 | Janssen Pharmaceutica, N.V. | Bicyclic thiazoles as allosteric modulators of mglur5 receptors |
BR112012014436A2 (en) | 2009-12-18 | 2019-09-24 | Janssen Pharmaceutica Nv | Bicyclic thiazoles as allosteric mglur5 receptor modulators |
WO2011075699A2 (en) | 2009-12-18 | 2011-06-23 | Sunovion Pharmaceuticals Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
ME02186B (en) | 2009-12-23 | 2016-02-20 | Takeda Pharmaceuticals Co | Fused heteroaromatic pyrrolidinones as syk inhibitors |
US8420661B2 (en) | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
MX2012013560A (en) | 2010-05-24 | 2013-03-05 | Univ Vanderbilt | Substituted-6-methylnicotinamides as mglur5 positive allosteric modulators. |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
UA113625C2 (en) | 2011-04-26 | 2017-02-27 | PYRAZOLIDINE-3-ON DERIVATIVES | |
CA2829170C (en) | 2011-04-26 | 2019-02-26 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
EP2723739B1 (en) | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
US20130123254A1 (en) | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
UA110862C2 (en) | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Ethinyl derivatives as allosteric modulators of metabotropic glutamate receptor 5 mglur |
UA110995C2 (en) | 2011-10-07 | 2016-03-10 | Ф. Хоффманн-Ля Рош Аг | ETHINYL DERIVATIVES AS MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR |
TWI519515B (en) * | 2011-12-21 | 2016-02-01 | 諾維拉治療公司 | Hepatitis b antiviral agents |
PT3176170T (en) | 2012-06-13 | 2019-02-05 | Incyte Holdings Corp | Substituted tricyclic compounds as fgfr inhibitors |
JP6089104B2 (en) | 2012-07-17 | 2017-03-01 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Arylethynyl derivatives |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
UA113223C2 (en) | 2012-08-13 | 2016-12-26 | ARYLETINYLPYRIMIDINE | |
BR112015006218A2 (en) | 2012-09-27 | 2017-07-04 | Hoffmann La Roche | arylethynyl derivatives |
CN104718191B (en) * | 2012-10-18 | 2016-06-29 | 霍夫曼-拉罗奇有限公司 | Ethynyl derivatives serving as MGLUR5 receptor activity modulators |
EP2909180B1 (en) * | 2012-10-18 | 2016-10-05 | F. Hoffmann-La Roche AG | Ethynyl derivatives as modulators of mglur5 receptor activity |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
PE20152033A1 (en) | 2013-04-19 | 2016-01-21 | Incyte Holdings Corp | BICYCLE HETEROCYCLES AS FGFR INHIBITORS |
AU2014327504B2 (en) * | 2013-09-25 | 2018-01-04 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
TWI649310B (en) * | 2014-01-10 | 2019-02-01 | 赫孚孟拉羅股份公司 | Acetylene derivative |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MA41551A (en) | 2015-02-20 | 2017-12-26 | Incyte Corp | BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
EP3617205B1 (en) | 2015-02-20 | 2021-08-04 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
TWI713497B (en) | 2015-02-26 | 2020-12-21 | 南韓商愛思開生物製藥股份有限公司 | Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same |
CN106146391A (en) * | 2015-04-15 | 2016-11-23 | 中国科学院上海药物研究所 | Substituted benzamide compound of 5-fragrance alkynyl and preparation method thereof, pharmaceutical composition and purposes |
PE20180358A1 (en) | 2015-06-03 | 2018-02-21 | Hoffmann La Roche | ETHINYL DERIVATIVES |
LT3319959T (en) | 2015-07-06 | 2021-12-27 | Alkermes, Inc. | Hetero-halo inhibitors of histone deacetylase |
WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
CA2984711C (en) | 2015-07-15 | 2023-08-29 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as metabotropic glutamate receptor modulators |
GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
SI3484889T1 (en) | 2016-07-18 | 2020-11-30 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
SG11201906164RA (en) | 2017-01-11 | 2019-08-27 | Rodin Therapeutics Inc | Bicyclic inhibitors of histone deacetylase |
GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
AR111960A1 (en) | 2017-05-26 | 2019-09-04 | Incyte Corp | CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION |
JP7152471B2 (en) | 2017-08-07 | 2022-10-12 | ロダン・セラピューティクス,インコーポレーテッド | Bicyclic inhibitor of histone deacetylase |
CN112867716A (en) | 2018-05-04 | 2021-05-28 | 因赛特公司 | Solid forms of FGFR inhibitors and methods for their preparation |
CA3099116A1 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Salts of an fgfr inhibitor |
DE102019200805A1 (en) * | 2019-01-23 | 2020-07-23 | Henkel Ag & Co. Kgaa | New fluorescent materials based on phthalimides |
WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
JOP20220083A1 (en) | 2019-10-14 | 2023-01-30 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
CA3162010A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
US11780840B2 (en) | 2020-07-02 | 2023-10-10 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
JP2023536137A (en) * | 2020-07-29 | 2023-08-23 | ヴィヴォゾン・インコーポレイテッド | Dual modulators of mGluR5 and 5-HT2A receptors and uses thereof |
CN116209663A (en) | 2020-08-17 | 2023-06-02 | 安力高医药股份有限公司 | Methods and compositions for targeting PD-L1 |
WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
AR125273A1 (en) | 2021-02-25 | 2023-07-05 | Incyte Corp | SPIROCYCLIC LACTAMS AS JAK2 INHIBITORS V617F |
US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
KR20230116709A (en) * | 2022-01-27 | 2023-08-04 | 주식회사 비보존 | Pharmaceutical composition for prevention or treatment of mental disorder |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
US20030073712A1 (en) * | 2001-07-23 | 2003-04-17 | Bing Wang | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
WO2004009549A2 (en) * | 2002-07-18 | 2004-01-29 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
EP1611096A4 (en) * | 2003-03-26 | 2007-08-29 | Merck & Co Inc | Benzamide modulators of metabotropic glutamate receptors |
BRPI0415179A (en) * | 2003-10-07 | 2006-11-28 | Renovis Inc | amide derivatives such as ion channel ligands and pharmaceutical compositions and methods of employing them |
GB0324159D0 (en) * | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
CN1950372A (en) * | 2004-05-10 | 2007-04-18 | 万有制药株式会社 | Imidazopyridine compound |
GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
JP2008531690A (en) * | 2005-02-28 | 2008-08-14 | レノビス, インコーポレイテッド | Amide derivatives as ion channel ligands and pharmaceutical compositions and methods using the same |
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KR20100033981A (en) | 2010-03-31 |
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NZ581817A (en) | 2012-05-25 |
JP5622568B2 (en) | 2014-11-12 |
CA2689282A1 (en) | 2008-12-11 |
HK1147068A1 (en) | 2011-07-29 |
WO2008151184A1 (en) | 2008-12-11 |
CN101795689A (en) | 2010-08-04 |
SG185285A1 (en) | 2012-11-29 |
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