EA200971143A1 - BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS FOR THEIR RECEIVING AND APPLICATION - Google Patents
BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS FOR THEIR RECEIVING AND APPLICATIONInfo
- Publication number
- EA200971143A1 EA200971143A1 EA200971143A EA200971143A EA200971143A1 EA 200971143 A1 EA200971143 A1 EA 200971143A1 EA 200971143 A EA200971143 A EA 200971143A EA 200971143 A EA200971143 A EA 200971143A EA 200971143 A1 EA200971143 A1 EA 200971143A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- compounds
- positive allosteric
- allosteric modulators
- benzamide
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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Abstract
В одном аспекте изобретение относится к соединениям, в том числе производным бензамида и циклическим производным бензамида, которые можно применять в качестве позитивных аллостерических модуляторов метаботропного глутаматного рецептора подтипа 5 (mGluR5); синтетическим способам получения соединений; фармацевтическим композициям, содержащим эти соединения; и способам лечения неврологических и психических заболеваний, связанных с глутаматной дисфункцией, путем применения таких соединений и композиций. Настоящий реферат предназначен в качестве обзора, представленного в целях исследования в конкретной области, техники и не ограничивает настоящего изобретения.In one aspect, the invention relates to compounds, including benzamide derivatives and cyclic benzamide derivatives, which can be used as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for producing compounds; pharmaceutical compositions containing these compounds; and methods of treating neurological and mental diseases associated with glutamate dysfunction, by applying such compounds and compositions. This abstract is intended as a review presented for the purpose of research in a specific field of technology and does not limit the present invention.
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PCT/US2008/065647 WO2008151184A1 (en) | 2007-06-03 | 2008-06-03 | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
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EA200971143A EA200971143A1 (en) | 2007-06-03 | 2008-06-03 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS FOR THEIR RECEIVING AND APPLICATION |
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CA (1) | CA2689282A1 (en) |
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US7834039B2 (en) | 2006-12-15 | 2010-11-16 | Abbott Laboratories | Oxadiazole compounds |
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- 2008-06-03 AU AU2008259776A patent/AU2008259776A1/en not_active Abandoned
- 2008-06-03 CN CN200880100770.6A patent/CN101795689B/en not_active Expired - Fee Related
- 2008-06-03 MX MX2009013169A patent/MX2009013169A/en not_active Application Discontinuation
- 2008-06-03 SG SG2012074621A patent/SG185285A1/en unknown
- 2008-06-03 NZ NZ581817A patent/NZ581817A/en not_active IP Right Cessation
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- 2008-06-03 KR KR1020097027281A patent/KR20100033981A/en not_active Application Discontinuation
- 2008-06-03 BR BRPI0812363-2A2A patent/BRPI0812363A2/en not_active IP Right Cessation
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CA2689282A1 (en) | 2008-12-11 |
CN101795689A (en) | 2010-08-04 |
BRPI0812363A2 (en) | 2015-02-03 |
NZ581817A (en) | 2012-05-25 |
HK1147068A1 (en) | 2011-07-29 |
SG185285A1 (en) | 2012-11-29 |
AU2008259776A2 (en) | 2010-01-28 |
KR20100033981A (en) | 2010-03-31 |
EP2162136A1 (en) | 2010-03-17 |
IL202508A0 (en) | 2010-06-30 |
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