IL202508A0 - Benzamide mglur5 positive allosteric modulators and methods of making and using the same - Google Patents

Benzamide mglur5 positive allosteric modulators and methods of making and using the same

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Publication number
IL202508A0
IL202508A0 IL202508A IL20250809A IL202508A0 IL 202508 A0 IL202508 A0 IL 202508A0 IL 202508 A IL202508 A IL 202508A IL 20250809 A IL20250809 A IL 20250809A IL 202508 A0 IL202508 A0 IL 202508A0
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IL
Israel
Prior art keywords
benzamide
making
methods
same
positive allosteric
Prior art date
Application number
IL202508A
Original Assignee
Univ Vanderbilt
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Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Publication of IL202508A0 publication Critical patent/IL202508A0/en

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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IL202508A 2007-06-03 2009-12-03 Benzamide mglur5 positive allosteric modulators and methods of making and using the same IL202508A0 (en)

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