EA200971143A1 - Бензамидные mglur5 позитивные аллостерические модуляторы и способы их получения и применения - Google Patents

Бензамидные mglur5 позитивные аллостерические модуляторы и способы их получения и применения

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Publication number
EA200971143A1
EA200971143A1 EA200971143A EA200971143A EA200971143A1 EA 200971143 A1 EA200971143 A1 EA 200971143A1 EA 200971143 A EA200971143 A EA 200971143A EA 200971143 A EA200971143 A EA 200971143A EA 200971143 A1 EA200971143 A1 EA 200971143A1
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EA
Eurasian Patent Office
Prior art keywords
methods
compounds
positive allosteric
allosteric modulators
benzamide
Prior art date
Application number
EA200971143A
Other languages
English (en)
Inventor
П. Джеффри Конн
Крейг У. Линдсли
Чарльз Дэвид Уивер
Элис Л. Родригес
Коллин М. Нисвендер
Кэрри К. Джоунс
Ричард Уилльямс
Original Assignee
Вандербилт Юниверсити
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Filing date
Publication date
Application filed by Вандербилт Юниверсити filed Critical Вандербилт Юниверсити
Publication of EA200971143A1 publication Critical patent/EA200971143A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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  • Pyridine Compounds (AREA)

Abstract

В одном аспекте изобретение относится к соединениям, в том числе производным бензамида и циклическим производным бензамида, которые можно применять в качестве позитивных аллостерических модуляторов метаботропного глутаматного рецептора подтипа 5 (mGluR5); синтетическим способам получения соединений; фармацевтическим композициям, содержащим эти соединения; и способам лечения неврологических и психических заболеваний, связанных с глутаматной дисфункцией, путем применения таких соединений и композиций. Настоящий реферат предназначен в качестве обзора, представленного в целях исследования в конкретной области, техники и не ограничивает настоящего изобретения.
EA200971143A 2007-06-03 2008-06-03 Бензамидные mglur5 позитивные аллостерические модуляторы и способы их получения и применения EA200971143A1 (ru)

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JP2010529135A (ja) 2010-08-26
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