BR112012020273A2 - Compostos de pirazolopiridina, pirazolopirazina, pirazolopirimidina, pirazolotiofeno e pirazolotiazol como pontencializadores alostéricos de mglur4, composições e métodos de tratamento de disfunção neurológica - Google Patents
Compostos de pirazolopiridina, pirazolopirazina, pirazolopirimidina, pirazolotiofeno e pirazolotiazol como pontencializadores alostéricos de mglur4, composições e métodos de tratamento de disfunção neurológicaInfo
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- BR112012020273A2 BR112012020273A2 BR112012020273A BR112012020273A BR112012020273A2 BR 112012020273 A2 BR112012020273 A2 BR 112012020273A2 BR 112012020273 A BR112012020273 A BR 112012020273A BR 112012020273 A BR112012020273 A BR 112012020273A BR 112012020273 A2 BR112012020273 A2 BR 112012020273A2
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- Prior art keywords
- methods
- compounds
- pyrazolothiophene
- pyrazolopyrimidine
- treatment
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/4164—1,3-Diazoles
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Abstract
COMPOSTOS DE PIRAZOLOPIRIDINA, PIRAZOLOPIRAZINA, PIRAZOLOPIRIMIDINA, PIRAZOLOTIOFENO E PIRAZOLOTIAZOL COMO POTENCIALIZADORES ALOSTÉRICOS DE MGLURA, COMPOSIÇÕES E MÉTODOS DE TRATAMENTO DE DISFUNÇÃO NEUROLÓGICA. Compostos de pirazolopiridina, pirazolopirazina, pirazolopirimidina, pirazolotiofeno e pirazolotiazol que são úteis como potencializadores alostéricos/moduladores alostéricos positivos do receptor metabotrópico de glutamato subtipo 4 (mG1uR4); métodos de síntese para a produção dos compostos; composições farmacêuticas compreendendo os compostos; e métodos de utilização dos compostos, por exemplo, no tratamento de distúrbios neurológicos e psiquiátricos ou de outro estado de doença associada à disfunção do glutamato.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30348110P | 2010-02-11 | 2010-02-11 | |
US201161430521P | 2011-01-06 | 2011-01-06 | |
PCT/US2011/024618 WO2011100607A1 (en) | 2010-02-11 | 2011-02-11 | Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction |
Publications (2)
Publication Number | Publication Date |
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BR112012020273A2 true BR112012020273A2 (pt) | 2017-08-29 |
BR112012020273A8 BR112012020273A8 (pt) | 2017-12-26 |
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ID=44368167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR112012020273A BR112012020273A8 (pt) | 2010-02-11 | 2011-02-11 | compostos de pirazolopiridina, pirazolopirazina, pirazolopirimidina, pirazolotiofeno e pirazolotiazol como pontencializadores alostéricos de mglur4, composições e métodos de tratamento de disfunção neurológica |
Country Status (16)
Country | Link |
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US (2) | US9163015B2 (pt) |
EP (1) | EP2533639A4 (pt) |
JP (1) | JP5883399B2 (pt) |
KR (1) | KR20130029368A (pt) |
CN (1) | CN102892288B (pt) |
AU (1) | AU2011215638B2 (pt) |
BR (1) | BR112012020273A8 (pt) |
CA (1) | CA2789427A1 (pt) |
CL (1) | CL2012002225A1 (pt) |
EA (1) | EA201290774A1 (pt) |
IL (1) | IL221390A0 (pt) |
MX (1) | MX2012009378A (pt) |
SG (1) | SG183263A1 (pt) |
TN (1) | TN2012000400A1 (pt) |
WO (1) | WO2011100607A1 (pt) |
ZA (1) | ZA201206416B (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2393785A4 (en) | 2009-01-28 | 2013-10-30 | Univ Vanderbilt | SUBSTITUTED 1,1,3,3-TETRAOXIDOBENZO [D] [1,3,2] DITHIAZOLE AS ALLOSTERIC MGLUR4 POTENTIATORS, COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTIONS |
US8759377B2 (en) | 2009-11-23 | 2014-06-24 | Vanderbilt University | Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
US9163015B2 (en) * | 2010-02-11 | 2015-10-20 | Vanderbilt University | Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
JP5957526B2 (ja) | 2011-09-15 | 2016-07-27 | ノバルティス アーゲー | チロシンキナーゼとしての6−置換3−(キノリン−6−イルチオ)−[1,2,4]トリアゾロ[4,3−a]ピラジン |
WO2013060029A1 (en) * | 2011-10-28 | 2013-05-02 | Merck Sharp & Dohme Corp | Allosteric modulators of metabotropic glutamate receptors |
WO2013088315A1 (en) | 2011-12-15 | 2013-06-20 | Pfizer Limited | Sulfonamide derivatives |
BR112014031899A8 (pt) | 2012-06-20 | 2017-10-24 | Univ Vanderbilt | composto, composição farmacêutica, e, método para tratamento de um distúrbio |
JP6402115B2 (ja) * | 2013-02-04 | 2018-10-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 神経学的疾患および状態の処置に有用なスピロ−キナゾリノン誘導体 |
CN105143228B (zh) * | 2013-05-10 | 2017-07-21 | 江苏豪森药业集团有限公司 | [1,2,4]三唑并[4,3‑a]吡啶类衍生物,其制备方法或其在医药上的应用 |
KR102365952B1 (ko) | 2013-10-14 | 2022-02-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 선택적으로 치환된 퀴놀린 화합물 |
EP3057964B1 (en) | 2013-10-14 | 2019-12-04 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
CN107074843A (zh) | 2014-04-25 | 2017-08-18 | 辉瑞公司 | 杂芳族化合物及其作为多巴胺d1配体的用途 |
US9980945B2 (en) | 2015-01-13 | 2018-05-29 | Vanderbilt University | Benzoisoxazole-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
US10221172B2 (en) | 2015-01-13 | 2019-03-05 | Vanderbilt University | Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
US10227343B2 (en) | 2015-01-30 | 2019-03-12 | Vanderbilt University | Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
US10526323B2 (en) | 2015-01-30 | 2020-01-07 | Vanderbilt University | Indazole and azaindazole substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
WO2016172547A1 (en) * | 2015-04-24 | 2016-10-27 | Vanderbilt University | Substituted imidazopyridine and triazolopyridine analogs as positive allosteric modulators of muscarinic acetylcholine receptor m1 |
US9987242B2 (en) | 2015-05-05 | 2018-06-05 | Northwestern University | Treatment of Levodopa-induced Dyskinesias |
US10710997B2 (en) | 2016-09-01 | 2020-07-14 | Vanderbilt University | Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
US10294222B2 (en) | 2016-09-01 | 2019-05-21 | Vanderbilt University | Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
WO2018080918A1 (en) * | 2016-10-26 | 2018-05-03 | Janssen Pharmaceutica Nv | 3-aryl-2h-pyrazolo[4,3-b]pyridine compounds and their use as ampa receptor modulators |
MA46722A (fr) * | 2016-11-07 | 2019-09-11 | Univ Vanderbilt | Modulateurs allostériques positifs du récepteur muscarinique à l'acétylcholine m4 |
WO2018089544A1 (en) | 2016-11-08 | 2018-05-17 | Vanderbilt University | Isoquinoline amine compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
WO2018089546A1 (en) * | 2016-11-08 | 2018-05-17 | Vanderbilt University | Isoquinoline ether compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
WO2019006157A1 (en) | 2017-06-28 | 2019-01-03 | Vanderbilt University | QUINOLINE PYRIDINE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIALIZERS, COMPOSITIONS, AND METHODS FOR TREATING NEUROLOGICAL DYSFUNCTIONS |
UA128084C2 (uk) | 2017-08-16 | 2024-04-03 | Вандербілт Юніверсіті | ІНДАЗОЛОВІ СПОЛУКИ ЯК АЛОСТЕРИЧНІ ПОТЕНЦІАТОРИ mGLuR4, КОМПОЗИЦІЇ І СПОСОБИ ЛІКУВАННЯ НЕВРОЛОГІЧНИХ ДИСФУНКЦІЙ |
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CA2422367C (en) * | 2000-09-15 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
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SE0302232D0 (sv) * | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
SE0303180D0 (sv) * | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
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WO2008089307A2 (en) * | 2007-01-18 | 2008-07-24 | Lexicon Pharmaceuticals, Inc. | Delta 5 desaturase inhibitors for the treatment of pain, inflammation and cancer |
GB0713686D0 (en) * | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
CN101790532B (zh) * | 2007-07-31 | 2013-11-20 | 沃泰克斯药物股份有限公司 | 5-氟-1H-吡唑并[3,4-b]吡啶-3-胺及其衍生物的制备方法 |
US9163015B2 (en) * | 2010-02-11 | 2015-10-20 | Vanderbilt University | Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
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BR112012020273A8 (pt) | 2017-12-26 |
CA2789427A1 (en) | 2011-08-18 |
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US9163015B2 (en) | 2015-10-20 |
TN2012000400A1 (en) | 2014-01-30 |
US20130065895A1 (en) | 2013-03-14 |
JP2013519684A (ja) | 2013-05-30 |
US20130096110A1 (en) | 2013-04-18 |
JP5883399B2 (ja) | 2016-03-15 |
EA201290774A1 (ru) | 2013-03-29 |
EP2533639A4 (en) | 2013-08-21 |
MX2012009378A (es) | 2012-09-12 |
WO2011100607A1 (en) | 2011-08-18 |
SG183263A1 (en) | 2012-09-27 |
EP2533639A1 (en) | 2012-12-19 |
AU2011215638A1 (en) | 2012-09-20 |
AU2011215638B2 (en) | 2016-04-28 |
CL2012002225A1 (es) | 2014-03-07 |
ZA201206416B (en) | 2013-10-30 |
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