EA201591404A1 - Спиролактамные модуляторы рецептора nmda и их применение - Google Patents

Спиролактамные модуляторы рецептора nmda и их применение

Info

Publication number
EA201591404A1
EA201591404A1 EA201591404A EA201591404A EA201591404A1 EA 201591404 A1 EA201591404 A1 EA 201591404A1 EA 201591404 A EA201591404 A EA 201591404A EA 201591404 A EA201591404 A EA 201591404A EA 201591404 A1 EA201591404 A1 EA 201591404A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nmda receptor
spirolactam
application
receptor modulators
compounds
Prior art date
Application number
EA201591404A
Other languages
English (en)
Inventor
Джон А. Лоу, III
М. Амин Кхан
Original Assignee
Аптиникс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50097881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201591404(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Аптиникс Инк. filed Critical Аптиникс Инк.
Publication of EA201591404A1 publication Critical patent/EA201591404A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Описаны соединения, обладающие улучшенной эффективностью модулирования активности рецептора NMDA. Указанные соединения предусмотрены для применения при лечении патологических состояний, таких как депрессия и родственные расстройства. Описаны также перорально доступные композиции и другие фармацевтически приемлемые формы доставки соединений, включая внутривенные композиции.
EA201591404A 2013-01-29 2014-01-29 Спиролактамные модуляторы рецептора nmda и их применение EA201591404A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361757939P 2013-01-29 2013-01-29
PCT/US2014/013626 WO2014120789A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
EA201591404A1 true EA201591404A1 (ru) 2016-01-29

Family

ID=50097881

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591404A EA201591404A1 (ru) 2013-01-29 2014-01-29 Спиролактамные модуляторы рецептора nmda и их применение

Country Status (16)

Country Link
US (2) US9738650B2 (ru)
EP (1) EP2951186B1 (ru)
JP (1) JP2016506961A (ru)
KR (1) KR20150110586A (ru)
CN (1) CN105026401A (ru)
AU (1) AU2014212490A1 (ru)
BR (1) BR112015018095A2 (ru)
CA (1) CA2899010A1 (ru)
CL (1) CL2015002124A1 (ru)
EA (1) EA201591404A1 (ru)
IL (1) IL240165A0 (ru)
MX (1) MX2015009778A (ru)
PE (1) PE20151438A1 (ru)
PH (1) PH12015501600A1 (ru)
SG (1) SG11201505937SA (ru)
WO (1) WO2014120789A1 (ru)

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Also Published As

Publication number Publication date
MX2015009778A (es) 2016-02-09
BR112015018095A2 (pt) 2017-07-18
CA2899010A1 (en) 2014-08-07
PH12015501600A1 (en) 2015-10-19
CN105026401A (zh) 2015-11-04
AU2014212490A1 (en) 2015-07-30
IL240165A0 (en) 2015-09-24
EP2951186B1 (en) 2018-07-25
PE20151438A1 (es) 2015-10-10
WO2014120789A1 (en) 2014-08-07
SG11201505937SA (en) 2015-09-29
CL2015002124A1 (es) 2015-12-04
US20150376195A1 (en) 2015-12-31
US20180155354A1 (en) 2018-06-07
JP2016506961A (ja) 2016-03-07
KR20150110586A (ko) 2015-10-02
EP2951186A1 (en) 2015-12-09
US9738650B2 (en) 2017-08-22
US10253032B2 (en) 2019-04-09

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