EA201892657A1 - Спиролактамовые модуляторы nmda-рецептора и их применение - Google Patents

Спиролактамовые модуляторы nmda-рецептора и их применение

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Publication number
EA201892657A1
EA201892657A1 EA201892657A EA201892657A EA201892657A1 EA 201892657 A1 EA201892657 A1 EA 201892657A1 EA 201892657 A EA201892657 A EA 201892657A EA 201892657 A EA201892657 A EA 201892657A EA 201892657 A1 EA201892657 A1 EA 201892657A1
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Eurasian Patent Office
Prior art keywords
nmda
receptor
spyrolactam
modulators
application
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Application number
EA201892657A
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English (en)
Inventor
М. Амин Хан
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Аптиникс Инк.
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Publication of EA201892657A1 publication Critical patent/EA201892657A1/ru

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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract

Раскрыты соединения, обладающие повышенной эффективностью при модулировании активности рецептора NMDA. Такие соединения могут применяться при лечении состояний, таких как депрессивный синдром и родственные расстройства. Также раскрыты перорально доступные лекарственные формы и другие фармацевтически приемлемый формы доставки соединений, включая лекарственные формы для внутривенного введения.
EA201892657A 2016-05-19 2017-05-18 Спиролактамовые модуляторы nmda-рецептора и их применение EA201892657A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662338767P 2016-05-19 2016-05-19
PCT/US2017/033323 WO2017201283A1 (en) 2016-05-19 2017-05-18 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
EA201892657A1 true EA201892657A1 (ru) 2019-05-31

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EA201892657A EA201892657A1 (ru) 2016-05-19 2017-05-18 Спиролактамовые модуляторы nmda-рецептора и их применение

Country Status (18)

Country Link
US (2) US9932347B2 (ru)
EP (1) EP3458458B1 (ru)
JP (1) JP6823083B2 (ru)
KR (1) KR102128675B1 (ru)
CN (1) CN109415372B (ru)
AU (1) AU2017267708B2 (ru)
BR (1) BR112018073663A2 (ru)
CA (1) CA3024606C (ru)
CL (1) CL2018003265A1 (ru)
CO (1) CO2018013747A2 (ru)
EA (1) EA201892657A1 (ru)
IL (1) IL263045B (ru)
MX (1) MX2018014202A (ru)
PE (1) PE20190174A1 (ru)
PH (1) PH12018502438A1 (ru)
SG (1) SG11201810280YA (ru)
WO (1) WO2017201283A1 (ru)
ZA (1) ZA201807731B (ru)

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