CL2015002124A1 - Moduladores de receptores nmda de espiro-lactama y sus usos - Google Patents
Moduladores de receptores nmda de espiro-lactama y sus usosInfo
- Publication number
- CL2015002124A1 CL2015002124A1 CL2015002124A CL2015002124A CL2015002124A1 CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1 CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1
- Authority
- CL
- Chile
- Prior art keywords
- modulators
- nmda receptors
- spiro
- lactam nmda
- lactam
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
Abstract
COMPUESTOS HETEROCICLOS DERIVADOS DE ESPIRO-LACTAMAS, MODULADORES DE LOS RECEPTORES NMDA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; UTILES PARA TRATAR ENFERMEDADES TALES COMO TRASTORNO DE DEFICIT ATENCIONAL, DEPRESION, ANSIEDAD, ENTRE OTRAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361757939P | 2013-01-29 | 2013-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015002124A1 true CL2015002124A1 (es) | 2015-12-04 |
Family
ID=50097881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015002124A CL2015002124A1 (es) | 2013-01-29 | 2015-07-29 | Moduladores de receptores nmda de espiro-lactama y sus usos |
Country Status (16)
Country | Link |
---|---|
US (2) | US9738650B2 (es) |
EP (1) | EP2951186B1 (es) |
JP (1) | JP2016506961A (es) |
KR (1) | KR20150110586A (es) |
CN (1) | CN105026401A (es) |
AU (1) | AU2014212490A1 (es) |
BR (1) | BR112015018095A2 (es) |
CA (1) | CA2899010A1 (es) |
CL (1) | CL2015002124A1 (es) |
EA (1) | EA201591404A1 (es) |
IL (1) | IL240165A0 (es) |
MX (1) | MX2015009778A (es) |
PE (1) | PE20151438A1 (es) |
PH (1) | PH12015501600A1 (es) |
SG (1) | SG11201505937SA (es) |
WO (1) | WO2014120789A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102186883B (zh) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda受体调节剂和其用途 |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
MX2015009785A (es) | 2013-01-29 | 2016-04-04 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
TR201908596T4 (tr) | 2013-01-29 | 2019-07-22 | Aptinyx Inc | Spiro-laktam NMDA reseptörü modülatörleri ve bunların kullanımları. |
BR112015018092A2 (pt) | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor de nmda de espiro-lactama e usos dos mesmos |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
EA201892657A1 (ru) | 2016-05-19 | 2019-05-31 | Аптиникс Инк. | Спиролактамовые модуляторы nmda-рецептора и их применение |
EA201990425A1 (ru) * | 2016-08-01 | 2019-08-30 | Аптиникс Инк. | Спиролактамовые и бис-спиролактамовые модуляторы nmda-рецептора и их применение |
CN109937204B (zh) | 2016-08-01 | 2022-11-25 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
US10918637B2 (en) | 2016-08-01 | 2021-02-16 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
MX2019001308A (es) | 2016-08-01 | 2019-05-30 | Aptinyx Inc | Moduladores nmda espiro-lactam y metodos de uso de los mismos. |
JP7036792B2 (ja) | 2016-08-01 | 2022-03-15 | アプティニックス インコーポレイテッド | スピロ-ラクタムnmda受容体修飾因子およびその使用 |
MX2020008107A (es) * | 2018-01-31 | 2020-09-25 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos. |
WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
CA3089559A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CN109485598A (zh) * | 2018-11-29 | 2019-03-19 | 河南师范大学 | 一种去除氨基上喹啉保护基的新方法 |
WO2021021996A1 (en) * | 2019-08-01 | 2021-02-04 | Aptinyx Inc. | Methods of treating disorders associated with elevated levels of antibodies that interact with the nmda receptor |
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EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
TR201908596T4 (tr) | 2013-01-29 | 2019-07-22 | Aptinyx Inc | Spiro-laktam NMDA reseptörü modülatörleri ve bunların kullanımları. |
MX2015009785A (es) | 2013-01-29 | 2016-04-04 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
BR112015018092A2 (pt) | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor de nmda de espiro-lactama e usos dos mesmos |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
-
2014
- 2014-01-29 EP EP14704255.0A patent/EP2951186B1/en active Active
- 2014-01-29 SG SG11201505937SA patent/SG11201505937SA/en unknown
- 2014-01-29 JP JP2015556102A patent/JP2016506961A/ja not_active Withdrawn
- 2014-01-29 AU AU2014212490A patent/AU2014212490A1/en not_active Abandoned
- 2014-01-29 CN CN201480006688.2A patent/CN105026401A/zh active Pending
- 2014-01-29 US US14/764,419 patent/US9738650B2/en active Active
- 2014-01-29 EA EA201591404A patent/EA201591404A1/ru unknown
- 2014-01-29 BR BR112015018095A patent/BR112015018095A2/pt not_active IP Right Cessation
- 2014-01-29 KR KR1020157021534A patent/KR20150110586A/ko not_active Application Discontinuation
- 2014-01-29 PE PE2015001565A patent/PE20151438A1/es not_active Application Discontinuation
- 2014-01-29 WO PCT/US2014/013626 patent/WO2014120789A1/en active Application Filing
- 2014-01-29 MX MX2015009778A patent/MX2015009778A/es unknown
- 2014-01-29 CA CA2899010A patent/CA2899010A1/en not_active Abandoned
-
2015
- 2015-07-20 PH PH12015501600A patent/PH12015501600A1/en unknown
- 2015-07-27 IL IL240165A patent/IL240165A0/en unknown
- 2015-07-29 CL CL2015002124A patent/CL2015002124A1/es unknown
-
2017
- 2017-07-19 US US15/653,738 patent/US10253032B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20180155354A1 (en) | 2018-06-07 |
US10253032B2 (en) | 2019-04-09 |
AU2014212490A1 (en) | 2015-07-30 |
IL240165A0 (en) | 2015-09-24 |
BR112015018095A2 (pt) | 2017-07-18 |
US9738650B2 (en) | 2017-08-22 |
CA2899010A1 (en) | 2014-08-07 |
WO2014120789A1 (en) | 2014-08-07 |
US20150376195A1 (en) | 2015-12-31 |
MX2015009778A (es) | 2016-02-09 |
EA201591404A1 (ru) | 2016-01-29 |
SG11201505937SA (en) | 2015-09-29 |
EP2951186A1 (en) | 2015-12-09 |
EP2951186B1 (en) | 2018-07-25 |
PH12015501600A1 (en) | 2015-10-19 |
JP2016506961A (ja) | 2016-03-07 |
PE20151438A1 (es) | 2015-10-10 |
CN105026401A (zh) | 2015-11-04 |
KR20150110586A (ko) | 2015-10-02 |
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