CL2015002124A1 - Moduladores de receptores nmda de espiro-lactama y sus usos - Google Patents

Moduladores de receptores nmda de espiro-lactama y sus usos

Info

Publication number
CL2015002124A1
CL2015002124A1 CL2015002124A CL2015002124A CL2015002124A1 CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1 CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A CL2015002124 A CL 2015002124A CL 2015002124 A1 CL2015002124 A1 CL 2015002124A1
Authority
CL
Chile
Prior art keywords
modulators
nmda receptors
spiro
lactam nmda
lactam
Prior art date
Application number
CL2015002124A
Other languages
English (en)
Inventor
M Amin Khan
John A Lowe Iii
Original Assignee
Aptinyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50097881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015002124(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of CL2015002124A1 publication Critical patent/CL2015002124A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)

Abstract

COMPUESTOS HETEROCICLOS DERIVADOS DE ESPIRO-LACTAMAS, MODULADORES DE LOS RECEPTORES NMDA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; UTILES PARA TRATAR ENFERMEDADES TALES COMO TRASTORNO DE DEFICIT ATENCIONAL, DEPRESION, ANSIEDAD, ENTRE OTRAS.
CL2015002124A 2013-01-29 2015-07-29 Moduladores de receptores nmda de espiro-lactama y sus usos CL2015002124A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361757939P 2013-01-29 2013-01-29

Publications (1)

Publication Number Publication Date
CL2015002124A1 true CL2015002124A1 (es) 2015-12-04

Family

ID=50097881

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002124A CL2015002124A1 (es) 2013-01-29 2015-07-29 Moduladores de receptores nmda de espiro-lactama y sus usos

Country Status (16)

Country Link
US (2) US9738650B2 (es)
EP (1) EP2951186B1 (es)
JP (1) JP2016506961A (es)
KR (1) KR20150110586A (es)
CN (1) CN105026401A (es)
AU (1) AU2014212490A1 (es)
BR (1) BR112015018095A2 (es)
CA (1) CA2899010A1 (es)
CL (1) CL2015002124A1 (es)
EA (1) EA201591404A1 (es)
IL (1) IL240165A0 (es)
MX (1) MX2015009778A (es)
PE (1) PE20151438A1 (es)
PH (1) PH12015501600A1 (es)
SG (1) SG11201505937SA (es)
WO (1) WO2014120789A1 (es)

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KR20150110586A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
BR112015018089B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor de nmda de espiro-lactama, composição farmacêutica os compreendendo e uso dos mesmos
PE20151416A1 (es) 2013-01-29 2015-10-10 Naurex Inc Moduladores de receptores nmda de espiro-lactama y sus usos
EP2951185B1 (en) 2013-01-29 2016-12-21 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
KR102128675B1 (ko) 2016-05-19 2020-06-30 앱티닉스 인크. 스피로-락탐 nmda 수용체 조정제 및 그의 용도
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
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AU2017305240B2 (en) * 2016-08-01 2021-12-09 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
EP3490990B1 (en) 2016-08-01 2023-12-06 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam nmda modulators and methods of using same
WO2018026763A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
IL264496B (en) * 2016-08-01 2022-09-01 Aptinyx Inc Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
US11578072B2 (en) * 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
MX2020008106A (es) * 2018-01-31 2020-09-25 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos.
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
CN109485598A (zh) * 2018-11-29 2019-03-19 河南师范大学 一种去除氨基上喹啉保护基的新方法
EP3986400B1 (en) * 2019-06-24 2024-08-21 Naurex Inc. Processes and intermediates for producing diazaspiro lactam compounds
EP4007574A4 (en) * 2019-08-01 2023-08-02 Aptinyx Inc. METHODS OF TREATING DISORDERS ASSOCIATED WITH HIGH LEVELS OF ANTIBODIES INTERACTING WITH THE NMDA RECEPTOR
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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BR112015018089B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor de nmda de espiro-lactama, composição farmacêutica os compreendendo e uso dos mesmos
PE20151416A1 (es) 2013-01-29 2015-10-10 Naurex Inc Moduladores de receptores nmda de espiro-lactama y sus usos

Also Published As

Publication number Publication date
KR20150110586A (ko) 2015-10-02
EA201591404A1 (ru) 2016-01-29
CA2899010A1 (en) 2014-08-07
PH12015501600A1 (en) 2015-10-19
EP2951186B1 (en) 2018-07-25
IL240165A0 (en) 2015-09-24
US10253032B2 (en) 2019-04-09
JP2016506961A (ja) 2016-03-07
US9738650B2 (en) 2017-08-22
SG11201505937SA (en) 2015-09-29
EP2951186A1 (en) 2015-12-09
WO2014120789A1 (en) 2014-08-07
US20150376195A1 (en) 2015-12-31
AU2014212490A1 (en) 2015-07-30
US20180155354A1 (en) 2018-06-07
PE20151438A1 (es) 2015-10-10
CN105026401A (zh) 2015-11-04
MX2015009778A (es) 2016-02-09
BR112015018095A2 (pt) 2017-07-18

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