PE20151427A1 - Moduladores de receptores nmda de espiro-lactama y sus usos - Google Patents
Moduladores de receptores nmda de espiro-lactama y sus usosInfo
- Publication number
- PE20151427A1 PE20151427A1 PE2015001568A PE2015001568A PE20151427A1 PE 20151427 A1 PE20151427 A1 PE 20151427A1 PE 2015001568 A PE2015001568 A PE 2015001568A PE 2015001568 A PE2015001568 A PE 2015001568A PE 20151427 A1 PE20151427 A1 PE 20151427A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- lactama
- spiro
- receiver modulators
- nmda
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se describen compuestos de formula (I), donde los sustituyentes R2, R5, R3, R1 y Rb estan descritos en el pliego de reivindicaciones, estos compuestos tienen una potencia mejorada en la modulacion de la actividad del receptor de NMDA. Dichos compuestos se contemplan para su uso en el tratamiento de afecciones tal como la depresion y trastornos vinculados. Tambien se describen formulaciones disponibles por via oral y otras formas de administracion farmaceuticamente aceptables de los compuestos, inclusive formulaciones intravenosas
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361757920P | 2013-01-29 | 2013-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20151427A1 true PE20151427A1 (es) | 2015-10-10 |
Family
ID=50069346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015001568A PE20151427A1 (es) | 2013-01-29 | 2014-01-29 | Moduladores de receptores nmda de espiro-lactama y sus usos |
Country Status (17)
Country | Link |
---|---|
US (5) | US9828384B2 (es) |
EP (1) | EP2951182B1 (es) |
JP (1) | JP6531042B2 (es) |
KR (1) | KR102410989B1 (es) |
CN (1) | CN105408336B (es) |
AU (1) | AU2014212485C1 (es) |
BR (1) | BR112015018089B1 (es) |
CA (1) | CA2898774C (es) |
CL (1) | CL2015002122A1 (es) |
EA (1) | EA032153B1 (es) |
HK (1) | HK1218418A1 (es) |
IL (1) | IL240162B (es) |
MX (1) | MX2015009772A (es) |
PE (1) | PE20151427A1 (es) |
PH (1) | PH12015501596A1 (es) |
SG (1) | SG11201505942YA (es) |
WO (1) | WO2014120784A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2011003015A (es) | 2008-09-18 | 2011-11-18 | Univ Northwestern | Moduladores del receptor de n-metil-d-aspartato, y usos de los mismos. |
US9708335B2 (en) | 2013-01-29 | 2017-07-18 | Apytinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
JP6531042B2 (ja) * | 2013-01-29 | 2019-06-12 | アプティニックス インコーポレイテッド | スピロラクタム系nmda受容体モジュレーターおよびその使用 |
MX2015009778A (es) | 2013-01-29 | 2016-02-09 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
CA2898863A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
HRP20221545T1 (hr) | 2013-01-29 | 2023-03-03 | Aptinyx Inc. | Spiro-lactam nmda receptorski modulatori i njihove uporabe |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
JP6823083B2 (ja) | 2016-05-19 | 2021-01-27 | アプティニックス インコーポレイテッド | スピロラクタム系nmda受容体モジュレーターおよびその使用 |
PE20190501A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores nmda espiro-lactam y metodos de uso de los mismos |
IL264496B (en) | 2016-08-01 | 2022-09-01 | Aptinyx Inc | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
MX2019001318A (es) | 2016-08-01 | 2019-07-01 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos. |
CA3031539C (en) | 2016-08-01 | 2023-11-28 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
BR112019001768A2 (pt) | 2016-08-01 | 2019-06-11 | Aptinyx Inc | moduladores do receptor de spiro-lactamas nmda e usos dos mesmos |
MX2020008106A (es) * | 2018-01-31 | 2020-09-25 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos. |
CA3089561A1 (en) | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2019152681A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2019152688A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
CN113966337B (zh) * | 2020-05-12 | 2024-01-02 | 北京广为医药科技有限公司 | 调节nmda受体活性的化合物、其药物组合物及用途 |
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HRP20221545T1 (hr) | 2013-01-29 | 2023-03-03 | Aptinyx Inc. | Spiro-lactam nmda receptorski modulatori i njihove uporabe |
US9708335B2 (en) | 2013-01-29 | 2017-07-18 | Apytinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CA2898863A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
MX2015009778A (es) | 2013-01-29 | 2016-02-09 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
JP6531042B2 (ja) | 2013-01-29 | 2019-06-12 | アプティニックス インコーポレイテッド | スピロラクタム系nmda受容体モジュレーターおよびその使用 |
-
2014
- 2014-01-29 JP JP2015556099A patent/JP6531042B2/ja active Active
- 2014-01-29 US US14/764,402 patent/US9828384B2/en active Active
- 2014-01-29 KR KR1020157023289A patent/KR102410989B1/ko active IP Right Grant
- 2014-01-29 EA EA201591402A patent/EA032153B1/ru unknown
- 2014-01-29 PE PE2015001568A patent/PE20151427A1/es unknown
- 2014-01-29 CN CN201480018643.7A patent/CN105408336B/zh active Active
- 2014-01-29 MX MX2015009772A patent/MX2015009772A/es active IP Right Grant
- 2014-01-29 EP EP14703247.8A patent/EP2951182B1/en active Active
- 2014-01-29 SG SG11201505942YA patent/SG11201505942YA/en unknown
- 2014-01-29 CA CA2898774A patent/CA2898774C/en active Active
- 2014-01-29 BR BR112015018089-2A patent/BR112015018089B1/pt active IP Right Grant
- 2014-01-29 WO PCT/US2014/013621 patent/WO2014120784A1/en active Application Filing
- 2014-01-29 AU AU2014212485A patent/AU2014212485C1/en active Active
-
2015
- 2015-07-20 PH PH12015501596A patent/PH12015501596A1/en unknown
- 2015-07-27 IL IL240162A patent/IL240162B/en active IP Right Grant
- 2015-07-29 CL CL2015002122A patent/CL2015002122A1/es unknown
-
2016
- 2016-06-06 HK HK16106443.2A patent/HK1218418A1/zh unknown
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2017
- 2017-08-08 US US15/671,409 patent/US20180179218A1/en not_active Abandoned
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2018
- 2018-03-28 US US15/938,040 patent/US20180215767A1/en not_active Abandoned
- 2018-05-02 US US15/968,976 patent/US20180244680A1/en not_active Abandoned
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2020
- 2020-07-02 US US16/919,438 patent/US20210155632A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SG11201505942YA (en) | 2015-08-28 |
MX2015009772A (es) | 2016-05-31 |
US20150368252A1 (en) | 2015-12-24 |
WO2014120784A1 (en) | 2014-08-07 |
EA032153B1 (ru) | 2019-04-30 |
US20180215767A1 (en) | 2018-08-02 |
CA2898774C (en) | 2021-07-13 |
JP2016506959A (ja) | 2016-03-07 |
CN105408336B (zh) | 2018-06-26 |
US9828384B2 (en) | 2017-11-28 |
AU2014212485C1 (en) | 2018-10-25 |
IL240162A0 (en) | 2015-09-24 |
CL2015002122A1 (es) | 2015-12-18 |
EA201591402A1 (ru) | 2015-12-30 |
US20210155632A1 (en) | 2021-05-27 |
BR112015018089B1 (pt) | 2022-09-20 |
IL240162B (en) | 2020-08-31 |
CA2898774A1 (en) | 2014-08-07 |
JP6531042B2 (ja) | 2019-06-12 |
EP2951182B1 (en) | 2020-03-18 |
KR102410989B1 (ko) | 2022-06-17 |
EP2951182A1 (en) | 2015-12-09 |
US20180244680A1 (en) | 2018-08-30 |
NZ709872A (en) | 2020-09-25 |
AU2014212485A1 (en) | 2015-07-30 |
CN105408336A (zh) | 2016-03-16 |
PH12015501596A1 (en) | 2015-10-19 |
US20180179218A1 (en) | 2018-06-28 |
HK1218418A1 (zh) | 2017-02-17 |
AU2014212485B2 (en) | 2018-04-19 |
BR112015018089A2 (pt) | 2017-07-18 |
KR20150110788A (ko) | 2015-10-02 |
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