PE20151436A1 - Moduladores de receptores nmda de espiro-lactama y sus usos - Google Patents

Moduladores de receptores nmda de espiro-lactama y sus usos

Info

Publication number
PE20151436A1
PE20151436A1 PE2015001571A PE2015001571A PE20151436A1 PE 20151436 A1 PE20151436 A1 PE 20151436A1 PE 2015001571 A PE2015001571 A PE 2015001571A PE 2015001571 A PE2015001571 A PE 2015001571A PE 20151436 A1 PE20151436 A1 PE 20151436A1
Authority
PE
Peru
Prior art keywords
lactama
spiro
compounds
receiver modulators
nmda
Prior art date
Application number
PE2015001571A
Other languages
English (en)
Inventor
Lowe John A Iii
M Amin Khan
Original Assignee
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50071824&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20151436(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of PE20151436A1 publication Critical patent/PE20151436A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)

Abstract

Se refiere al desarrollo de compuestos de formula (I), donde los sustituyentes R, R1 a R5, Rb y X tienen los valores dados en la descripcion. Estos compuestos tienen potencia mejorada para la modulacion de la actividad de los receptores NMDA. Se contempla su uso en el tratamiento de afecciones tales como la depresion y trastornos relacionados. Tambien se divulgan formulaciones disponibles oralmente y otras formas de administracion de los compuestos farmaceuticamente aceptables incluidas formulaciones intravenosas
PE2015001571A 2013-01-29 2014-01-29 Moduladores de receptores nmda de espiro-lactama y sus usos PE20151436A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361757942P 2013-01-29 2013-01-29

Publications (1)

Publication Number Publication Date
PE20151436A1 true PE20151436A1 (es) 2015-10-10

Family

ID=50071824

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015001571A PE20151436A1 (es) 2013-01-29 2014-01-29 Moduladores de receptores nmda de espiro-lactama y sus usos

Country Status (16)

Country Link
US (2) US9708335B2 (es)
EP (1) EP2951185B1 (es)
JP (1) JP2016506962A (es)
KR (1) KR20150110784A (es)
CN (1) CN105308049A (es)
AU (1) AU2014212501A1 (es)
BR (1) BR112015018094A2 (es)
CA (1) CA2899191A1 (es)
EA (1) EA201591405A1 (es)
ES (1) ES2618421T3 (es)
IL (1) IL240164A0 (es)
MX (1) MX2015009785A (es)
PE (1) PE20151436A1 (es)
PH (1) PH12015501598A1 (es)
SG (1) SG11201505862TA (es)
WO (1) WO2014120800A1 (es)

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BR112015018089B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor de nmda de espiro-lactama, composição farmacêutica os compreendendo e uso dos mesmos
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US11578072B2 (en) * 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
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WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
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Also Published As

Publication number Publication date
JP2016506962A (ja) 2016-03-07
IL240164A0 (en) 2015-09-24
PH12015501598A1 (en) 2015-10-19
EP2951185B1 (en) 2016-12-21
WO2014120800A1 (en) 2014-08-07
US20180127430A1 (en) 2018-05-10
US20150368254A1 (en) 2015-12-24
BR112015018094A2 (pt) 2017-07-18
US9708335B2 (en) 2017-07-18
AU2014212501A1 (en) 2015-07-30
KR20150110784A (ko) 2015-10-02
EP2951185A1 (en) 2015-12-09
US10316041B2 (en) 2019-06-11
CN105308049A (zh) 2016-02-03
SG11201505862TA (en) 2015-08-28
MX2015009785A (es) 2016-04-04
CA2899191A1 (en) 2014-08-07
ES2618421T3 (es) 2017-06-21
EA201591405A1 (ru) 2017-05-31

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