SG11201505862TA - Spiro-lactam nmda receptor modulators and uses thereof - Google Patents
Spiro-lactam nmda receptor modulators and uses thereofInfo
- Publication number
- SG11201505862TA SG11201505862TA SG11201505862TA SG11201505862TA SG11201505862TA SG 11201505862T A SG11201505862T A SG 11201505862TA SG 11201505862T A SG11201505862T A SG 11201505862TA SG 11201505862T A SG11201505862T A SG 11201505862TA SG 11201505862T A SG11201505862T A SG 11201505862TA
- Authority
- SG
- Singapore
- Prior art keywords
- spiro
- nmda receptor
- receptor modulators
- lactam nmda
- lactam
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361757942P | 2013-01-29 | 2013-01-29 | |
PCT/US2014/013639 WO2014120800A1 (en) | 2013-01-29 | 2014-01-29 | Spiro-lactam nmda receptor modulators and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201505862TA true SG11201505862TA (en) | 2015-08-28 |
Family
ID=50071824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201505862TA SG11201505862TA (en) | 2013-01-29 | 2014-01-29 | Spiro-lactam nmda receptor modulators and uses thereof |
Country Status (16)
Country | Link |
---|---|
US (2) | US9708335B2 (es) |
EP (1) | EP2951185B1 (es) |
JP (1) | JP2016506962A (es) |
KR (1) | KR20150110784A (es) |
CN (1) | CN105308049A (es) |
AU (1) | AU2014212501A1 (es) |
BR (1) | BR112015018094A2 (es) |
CA (1) | CA2899191A1 (es) |
EA (1) | EA201591405A1 (es) |
ES (1) | ES2618421T3 (es) |
IL (1) | IL240164A0 (es) |
MX (1) | MX2015009785A (es) |
PE (1) | PE20151436A1 (es) |
PH (1) | PH12015501598A1 (es) |
SG (1) | SG11201505862TA (es) |
WO (1) | WO2014120800A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2553968T3 (es) | 2008-09-18 | 2015-12-15 | Northwestern University | Moduladores del receptor NMDA y sus usos |
MX2015009772A (es) | 2013-01-29 | 2016-05-31 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
US9708335B2 (en) | 2013-01-29 | 2017-07-18 | Apytinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CN105229010A (zh) * | 2013-01-29 | 2016-01-06 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
CN105026401A (zh) | 2013-01-29 | 2015-11-04 | 诺雷克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
KR102280616B1 (ko) | 2013-01-29 | 2021-07-21 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
AU2015271719A1 (en) | 2014-06-04 | 2016-12-01 | Rugen Holdings (Cayman) Limited | Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists |
EP3194403B1 (en) | 2014-09-15 | 2019-02-06 | Rugen Holdings (Cayman) Limited | Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists |
EP3253761A4 (en) | 2015-02-04 | 2018-06-20 | Rugen Holdings (Cayman) Limited | 3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists |
KR102613179B1 (ko) | 2015-06-01 | 2023-12-14 | 뤼겐 홀딩스 (케이맨) 리미티드 | Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물 |
US20210198315A1 (en) * | 2016-02-01 | 2021-07-01 | Naurex, INC | Process for synthesis of peptide compounds |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA3024606C (en) | 2016-05-19 | 2019-09-03 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
SG10202101055VA (en) * | 2016-08-01 | 2021-03-30 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
SG11201900558RA (en) * | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
WO2018026798A1 (en) * | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
CN109661398B (zh) * | 2016-08-01 | 2022-07-05 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途 |
AU2017305240B2 (en) * | 2016-08-01 | 2021-12-09 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
WO2018098128A1 (en) | 2016-11-22 | 2018-05-31 | Rugen Holdings (Cayman) Limited | Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders |
WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
BR112020015666A2 (pt) * | 2018-01-31 | 2021-02-23 | Aptinyx Inc. | moduladores de espiro-lactamas de receptores nmda e usos dos mesmos |
WO2019152688A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
MX2020008107A (es) * | 2018-01-31 | 2020-09-25 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos. |
WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CN114008052A (zh) | 2019-06-14 | 2022-02-01 | 詹森药业有限公司 | 取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途 |
US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
CN111018746A (zh) * | 2019-12-16 | 2020-04-17 | 山东金城柯瑞化学有限公司 | 一种氨曲南主环合成中间体n-苄氧羰基-l-苏氨酸酰胺的合成方法 |
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US9708335B2 (en) | 2013-01-29 | 2017-07-18 | Apytinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
MX2015009772A (es) | 2013-01-29 | 2016-05-31 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
CN105026401A (zh) | 2013-01-29 | 2015-11-04 | 诺雷克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
CN105229010A (zh) | 2013-01-29 | 2016-01-06 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
KR102280616B1 (ko) | 2013-01-29 | 2021-07-21 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
-
2014
- 2014-01-29 US US14/764,426 patent/US9708335B2/en active Active
- 2014-01-29 WO PCT/US2014/013639 patent/WO2014120800A1/en active Application Filing
- 2014-01-29 AU AU2014212501A patent/AU2014212501A1/en not_active Abandoned
- 2014-01-29 EA EA201591405A patent/EA201591405A1/ru unknown
- 2014-01-29 ES ES14703750.1T patent/ES2618421T3/es active Active
- 2014-01-29 CA CA2899191A patent/CA2899191A1/en not_active Abandoned
- 2014-01-29 PE PE2015001571A patent/PE20151436A1/es not_active Application Discontinuation
- 2014-01-29 EP EP14703750.1A patent/EP2951185B1/en active Active
- 2014-01-29 SG SG11201505862TA patent/SG11201505862TA/en unknown
- 2014-01-29 MX MX2015009785A patent/MX2015009785A/es unknown
- 2014-01-29 CN CN201480018644.1A patent/CN105308049A/zh active Pending
- 2014-01-29 BR BR112015018094A patent/BR112015018094A2/pt not_active IP Right Cessation
- 2014-01-29 JP JP2015556106A patent/JP2016506962A/ja not_active Withdrawn
- 2014-01-29 KR KR1020157023269A patent/KR20150110784A/ko not_active Application Discontinuation
-
2015
- 2015-07-20 PH PH12015501598A patent/PH12015501598A1/en unknown
- 2015-07-27 IL IL240164A patent/IL240164A0/en unknown
-
2017
- 2017-06-16 US US15/625,163 patent/US10316041B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2951185B1 (en) | 2016-12-21 |
AU2014212501A1 (en) | 2015-07-30 |
US20150368254A1 (en) | 2015-12-24 |
US20180127430A1 (en) | 2018-05-10 |
WO2014120800A1 (en) | 2014-08-07 |
JP2016506962A (ja) | 2016-03-07 |
BR112015018094A2 (pt) | 2017-07-18 |
MX2015009785A (es) | 2016-04-04 |
PE20151436A1 (es) | 2015-10-10 |
CN105308049A (zh) | 2016-02-03 |
ES2618421T3 (es) | 2017-06-21 |
IL240164A0 (en) | 2015-09-24 |
KR20150110784A (ko) | 2015-10-02 |
EP2951185A1 (en) | 2015-12-09 |
PH12015501598A1 (en) | 2015-10-19 |
CA2899191A1 (en) | 2014-08-07 |
EA201591405A1 (ru) | 2017-05-31 |
US10316041B2 (en) | 2019-06-11 |
US9708335B2 (en) | 2017-07-18 |
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