SG11201505862TA - Spiro-lactam nmda receptor modulators and uses thereof - Google Patents

Spiro-lactam nmda receptor modulators and uses thereof

Info

Publication number
SG11201505862TA
SG11201505862TA SG11201505862TA SG11201505862TA SG11201505862TA SG 11201505862T A SG11201505862T A SG 11201505862TA SG 11201505862T A SG11201505862T A SG 11201505862TA SG 11201505862T A SG11201505862T A SG 11201505862TA SG 11201505862T A SG11201505862T A SG 11201505862TA
Authority
SG
Singapore
Prior art keywords
spiro
nmda receptor
receptor modulators
lactam nmda
lactam
Prior art date
Application number
SG11201505862TA
Inventor
John A Lowe
M Amin Khan
Original Assignee
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50071824&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201505862T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of SG11201505862TA publication Critical patent/SG11201505862TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201505862TA 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof SG11201505862TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361757942P 2013-01-29 2013-01-29
PCT/US2014/013639 WO2014120800A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
SG11201505862TA true SG11201505862TA (en) 2015-08-28

Family

ID=50071824

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505862TA SG11201505862TA (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Country Status (16)

Country Link
US (2) US9708335B2 (en)
EP (1) EP2951185B1 (en)
JP (1) JP2016506962A (en)
KR (1) KR20150110784A (en)
CN (1) CN105308049A (en)
AU (1) AU2014212501A1 (en)
BR (1) BR112015018094A2 (en)
CA (1) CA2899191A1 (en)
EA (1) EA201591405A1 (en)
ES (1) ES2618421T3 (en)
IL (1) IL240164A0 (en)
MX (1) MX2015009785A (en)
PE (1) PE20151436A1 (en)
PH (1) PH12015501598A1 (en)
SG (1) SG11201505862TA (en)
WO (1) WO2014120800A1 (en)

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AU2014212485C1 (en) 2013-01-29 2018-10-25 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CN105229010A (en) * 2013-01-29 2016-01-06 阿普廷伊克斯股份有限公司 Spiral shell-lactan nmda receptor conditioning agent and uses thereof
LT2951183T (en) 2013-01-29 2019-05-27 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
JP2016506961A (en) 2013-01-29 2016-03-07 ノーレックス, インコーポレイテッドNaurex, Inc. Spirolactam NMDA receptor modulator and use thereof
AU2015271719A1 (en) 2014-06-04 2016-12-01 Rugen Holdings (Cayman) Limited Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists
CA2957898C (en) 2014-09-15 2023-02-21 Rugen Holdings (Cayman) Limited Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
US10221182B2 (en) 2015-02-04 2019-03-05 Rugen Holdings (Cayman) Limited 3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
AU2016270677B2 (en) 2015-06-01 2020-11-12 Rugen Holdings (Cayman) Limited 3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
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WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
EP3490974B1 (en) * 2016-08-01 2023-12-06 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam nmda receptor modulators and uses thereof
PE20190501A1 (en) * 2016-08-01 2019-04-10 Aptinyx Inc NMDA ESPIRO-LACTAM MODULATORS AND METHODS OF USE OF THE SAME
EA201990425A1 (en) * 2016-08-01 2019-08-30 Аптиникс Инк. SPIRO-LACTAM AND BIS-SPIRO-LACTAM MODULATORS OF THE NMDA RECEPTOR AND THEIR APPLICATION
CA3031537A1 (en) * 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
IL286107B1 (en) 2016-08-01 2024-05-01 Aptinyx Inc Spiro-lactam nmda receptor modulators and usesthereof
US11000526B2 (en) 2016-11-22 2021-05-11 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
WO2019152688A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
BR112020015666A2 (en) * 2018-01-31 2021-02-23 Aptinyx Inc. nmda receptor spiro-lactam modulators and their uses
PE20210455A1 (en) * 2018-01-31 2021-03-08 Aptinyx Inc SPIRO-LACTAMA NMDA RECEIVER MODULATORS AND USES OF THEM
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Also Published As

Publication number Publication date
US10316041B2 (en) 2019-06-11
IL240164A0 (en) 2015-09-24
ES2618421T3 (en) 2017-06-21
EP2951185A1 (en) 2015-12-09
US20150368254A1 (en) 2015-12-24
US20180127430A1 (en) 2018-05-10
KR20150110784A (en) 2015-10-02
CA2899191A1 (en) 2014-08-07
EP2951185B1 (en) 2016-12-21
PE20151436A1 (en) 2015-10-10
EA201591405A1 (en) 2017-05-31
WO2014120800A1 (en) 2014-08-07
BR112015018094A2 (en) 2017-07-18
PH12015501598A1 (en) 2015-10-19
AU2014212501A1 (en) 2015-07-30
CN105308049A (en) 2016-02-03
US9708335B2 (en) 2017-07-18
MX2015009785A (en) 2016-04-04
JP2016506962A (en) 2016-03-07

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