ME02887B - 2-(2,4,5-supstituisani-anilino) pirimidinski derivati kao egfr modulatori korisni za tretman raka - Google Patents

2-(2,4,5-supstituisani-anilino) pirimidinski derivati kao egfr modulatori korisni za tretman raka

Info

Publication number
ME02887B
ME02887B MEP-2017-290A MEP2017290A ME02887B ME 02887 B ME02887 B ME 02887B ME P2017290 A MEP2017290 A ME P2017290A ME 02887 B ME02887 B ME 02887B
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ME
Montenegro
Prior art keywords
compound
pharmaceutically acceptable
cancer
acceptable salt
amino
Prior art date
Application number
MEP-2017-290A
Other languages
German (de)
English (en)
French (fr)
Inventor
Vasantha Krishna Kadambar
Sam Butterworth
Maurice Raymond Verschoyle Finlay
Richard Andrew Ward
Chandrasekhara Reddy Chintakuntla
Andiappan Murugan
Claudio Edmundo Chuaqui
Heather Marie Redfearn
Original Assignee
Astrazeneca Ab
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46875901&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02887(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ME02887B publication Critical patent/ME02887B/me

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal Substances (AREA)
  • Luminescent Compositions (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Claims (12)

1. Jedinjenje naznačeno time što je izabrano od N-(2-[2-dimetilaminoetil-metilamino]-5-{[4-(1H-indol-3-il)pirimidin-2-il]amino}-4-metoksifenil)-prop-2-enamida: i N-(4-metoksi-5-{[4-(1-metilindol-3-il)pirimidin-2-il]amino}-2-[metil-(2-metilaminoetil)amino]fenil)prop-2-enamida: ili njihova farmaceutski prihvatljiva so.
2. Jedinjenje prema zahtevu 1 naznačeno time što je N-(2-[2-dimetilaminoetil-metilamino]-5-{[4-(1H-indol-3-il)pirimidin-2-il]amino}-4-metoksifenil)-prop-2-enamid
3. Jedinjenje kako je zatraženo u zahtevu 1, naznačeno time što je N-(4-metoksi-5-{[4-(1-metilindol-3-il)pirimidin-2-il]amino}}-2-[metil-(2-metilaminoetil)amino]fenil)prop-2-enamid.
4. Farmaceutska kompozicija, naznačena time, što sadrži jedinjenje ili neku njegovu farmaceutski prihvatljivu so kao šta se zahteva u bilo kojem od zahteva od 1 do 3 zajedno sa nekim farmaceutski prihvatljivim razređivačem ili nosiocem.
5. Jedinjenje ili neka njegova farmaceutski prihvatljiva so kao šta se zahteva u bilo kojem od zahteva od 1 do 3, naznačeno time, što se upotrebljava kao lek.
6. Jedinjenje ili neka njegova farmaceutski prihvatljiva so kao šta se zahteva u bilo kojem od zahteva od 1 do 3, naznačeno time, što se koristi u tretmanu raka.
7. Jedinjenje ili neka njegova farmaceutski prihvatljiva so prema zahtevu 6, naznačeno time, što karcinom je nesitnoćelijski karcinom pluća.
8. Jedinjenje ili neka njegova farmaceutski prihvatljiva so kao šta se zahteva u bilo kojem od zahteva od 1 do 3, naznačeno time, što se upotrebljava u tretmanu bolesti koje su posredovane mutantom L858R EGFR i/ili mutantom T790M EGFR i/ili mutantom koji aktiviše deleciju Egzona 19.
9. Farmaceutski proizvod koji sadrži jedinjenje ili neku njegovu farmaceutski prihvatljiva so, kao šta se zahteva u bilo kojem od zahteva od 1 do 3, i dodatnu anti-tumorsku supstanciju, naznačen time, što se koristi za objedinjeni tretman raka.
10. Farmaceutski produkt kao šta se zahteva u zahtevu 9, naznačen time, što pomenuti rak je nesitnoćelijski karcinom pluća.
11. Jedinjenje ili neka njegova farmaceutski prihvatljiva so, kao šta se zahteva u bilo kojem od zahteva od 1 do 3, i neka dodatna anti-tumorska supstancija, naznačeno time, što se upotrebljava u objedinjenom tretmanu raka.
12. Jedinjenje ili neka njegova farmaceutski prihvatljiva so, kao šta se zahteva u bilo kojem od zahteva od 1 do 3, i neka dodatna anti-tumorska supstancija, naznačeno time, što se upotrebljava u objedinjenom tretmanu nesitnoćelijskog karcinoma pluća.
MEP-2017-290A 2011-07-27 2012-07-25 2-(2,4,5-supstituisani-anilino) pirimidinski derivati kao egfr modulatori korisni za tretman raka ME02887B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161512061P 2011-07-27 2011-07-27
US201261591363P 2012-01-27 2012-01-27
EP15192658.1A EP3009431B1 (en) 2011-07-27 2012-07-25 2-(2,4,5-substituted-anilino)pyrimidine derivatives as egfr modulators useful for treating cancer

Publications (1)

Publication Number Publication Date
ME02887B true ME02887B (me) 2018-04-20

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ID=46875901

Family Applications (3)

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MEP-2016-34A ME02382B (me) 2011-07-27 2012-07-25 2-(2,4,5-supstituisani-anilino) piramidisnki derivati kao egfr modulatori korisni za tretman raka
MEP-2020-87A ME03785B (me) 2011-07-27 2012-07-25 2-(2,4,5-supstituisani-anilino)pirimidinski derivati kao egfr modulatori korisni za liječenje raka
MEP-2017-290A ME02887B (me) 2011-07-27 2012-07-25 2-(2,4,5-supstituisani-anilino) pirimidinski derivati kao egfr modulatori korisni za tretman raka

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MEP-2016-34A ME02382B (me) 2011-07-27 2012-07-25 2-(2,4,5-supstituisani-anilino) piramidisnki derivati kao egfr modulatori korisni za tretman raka
MEP-2020-87A ME03785B (me) 2011-07-27 2012-07-25 2-(2,4,5-supstituisani-anilino)pirimidinski derivati kao egfr modulatori korisni za liječenje raka

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JP (3) JP5427321B2 (me)
KR (3) KR101691268B1 (me)
CN (7) CN105198862B (me)
AR (1) AR087336A1 (me)
AU (1) AU2012288626C1 (me)
BR (4) BR122014026094B1 (me)
CA (5) CA2843109C (me)
CL (1) CL2013003281A1 (me)
CO (1) CO6811863A2 (me)
CR (1) CR20130629A (me)
CY (4) CY1117431T1 (me)
DK (5) DK3686193T3 (me)
DO (1) DOP2013000263A (me)
EA (3) EA024421B1 (me)
EC (1) ECSP13013033A (me)
ES (5) ES2914854T3 (me)
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HR (4) HRP20160135T1 (me)
HU (4) HUE049060T2 (me)
IL (6) IL229199A (me)
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ME (3) ME02382B (me)
MX (3) MX377900B (me)
MY (2) MY161925A (me)
NI (1) NI201300134A (me)
PE (1) PE20141700A1 (me)
PH (2) PH12013502312A1 (me)
PL (5) PL3686193T3 (me)
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RS (4) RS54653B1 (me)
SG (5) SG194783A1 (me)
SI (4) SI3686194T1 (me)
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