CN113683612B - 一种帕布昔利布的制备方法 - Google Patents
一种帕布昔利布的制备方法 Download PDFInfo
- Publication number
- CN113683612B CN113683612B CN202111042732.3A CN202111042732A CN113683612B CN 113683612 B CN113683612 B CN 113683612B CN 202111042732 A CN202111042732 A CN 202111042732A CN 113683612 B CN113683612 B CN 113683612B
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- water
- reaction
- palbociclib
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Description
时间(min) | 流动相A | 流动相B |
0 | 80 | 20 |
30 | 20 | 80 |
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41 | 80 | 20 |
55 | 80 | 20 |
Claims (6)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111042732.3A CN113683612B (zh) | 2021-09-07 | 2021-09-07 | 一种帕布昔利布的制备方法 |
PCT/CN2022/094111 WO2023035667A1 (zh) | 2021-09-07 | 2022-05-20 | 一种帕布昔利布的低成本制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111042732.3A CN113683612B (zh) | 2021-09-07 | 2021-09-07 | 一种帕布昔利布的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN113683612A CN113683612A (zh) | 2021-11-23 |
CN113683612B true CN113683612B (zh) | 2022-06-17 |
Family
ID=78585536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202111042732.3A Active CN113683612B (zh) | 2021-09-07 | 2021-09-07 | 一种帕布昔利布的制备方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN113683612B (zh) |
WO (1) | WO2023035667A1 (zh) |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20060111716A (ko) * | 2002-01-22 | 2006-10-27 | 워너-램버트 캄파니 엘엘씨 | 2-(피리딘-2-일아미노)-피리도[2,3-d]피리미딘-7-온 |
KR20090052385A (ko) * | 2006-09-08 | 2009-05-25 | 화이자 프로덕츠 인크. | 2-(피리딘-2-일아미노)-피리도[2,3-d]피리미딘-7-온의합성 |
CN105348266B (zh) * | 2011-07-27 | 2018-04-10 | 阿斯利康(瑞典)有限公司 | 取代的3‑氯‑n‑[3‑(嘧啶‑2‑基氨基)苯基]丙酰胺或其盐 |
EP3186252A1 (en) * | 2014-08-28 | 2017-07-05 | ratiopharm GmbH | Method of producing palbociclib and pharmaceutical compositions comprising the same |
CN104447739B (zh) * | 2014-11-07 | 2016-02-17 | 郑州泰基鸿诺药物科技有限公司 | 一种氘代Palbociclib衍生物、制备方法及应用 |
CN104610254B (zh) * | 2015-01-26 | 2017-02-01 | 新发药业有限公司 | 一种帕博赛布的低成本制备方法 |
CN104910149A (zh) * | 2015-04-28 | 2015-09-16 | 上海百奇医药科技有限公司 | 一种Palbociclib制备方法 |
CN104892604B (zh) * | 2015-06-19 | 2016-08-24 | 北京康立生医药技术开发有限公司 | 一种cdk4抑制剂的合成方法 |
CN106831759A (zh) * | 2015-12-03 | 2017-06-13 | 上海星泰医药科技有限公司 | 帕布昔利布及其中间体的制备方法 |
CN105541832A (zh) * | 2015-12-15 | 2016-05-04 | 南京艾德凯腾生物医药有限责任公司 | 一种羟乙基磺酸盐帕布昔利布的制备方法 |
CN105924439B (zh) * | 2016-06-24 | 2017-11-24 | 石家庄海瑞药物科技有限公司 | 一种帕布昔利布的制备方法 |
CN106220627A (zh) * | 2016-07-31 | 2016-12-14 | 合肥远志医药科技开发有限公司 | 一种高纯度帕布昔利布的工业化制备方法 |
US10710999B2 (en) * | 2016-10-07 | 2020-07-14 | Mylan Laboratories Limited | Polymorph of an intermediate for palbociclib synthesis |
CN106565707B (zh) * | 2016-11-03 | 2019-01-04 | 杭州科巢生物科技有限公司 | 帕博西尼新合成方法 |
CN108283940B (zh) * | 2018-01-22 | 2021-01-29 | 重庆华邦制药有限公司 | 帕布昔利布中间体的制备方法 |
CN109336886A (zh) * | 2018-12-07 | 2019-02-15 | 重庆三圣实业股份有限公司 | 一种帕博西尼的制备方法及其产品 |
CN109867673B (zh) * | 2019-04-16 | 2021-03-16 | 淮海工学院 | 一种合成帕布昔利布的方法 |
CN112661753B (zh) * | 2020-12-29 | 2022-06-03 | 山东铂源药业股份有限公司 | 一种帕布昔利布中间体的制备方法 |
CN112898299B (zh) * | 2021-01-26 | 2021-11-26 | 山东铂源药业有限公司 | 一种帕布昔利布中间体的制备方法 |
-
2021
- 2021-09-07 CN CN202111042732.3A patent/CN113683612B/zh active Active
-
2022
- 2022-05-20 WO PCT/CN2022/094111 patent/WO2023035667A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN113683612A (zh) | 2021-11-23 |
WO2023035667A1 (zh) | 2023-03-16 |
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Address after: 251400 No. 12, Taixing East Street, Jibei Economic Development Zone, Jiyang District, Jinan City, Shandong Province Applicant after: Shandong Baoyuan Pharmaceutical Co.,Ltd. Address before: Strong in Jiyang County of Ji'nan City, 251400 North Street, Shandong Province Economic Development Zone Applicant before: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. |
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GR01 | Patent grant | ||
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation of Pabucilib Effective date of registration: 20221130 Granted publication date: 20220617 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan science and technology innovation center sub branch Pledgor: Shandong Baoyuan Pharmaceutical Co.,Ltd. Registration number: Y2022980023658 |