EA201400358A1 - Замещенные n-[1-циано-2-(фенил)этил]-2-азабицикло[2.2.1]гептан-3-карбоксамидные ингибиторы катепсина с - Google Patents

Замещенные n-[1-циано-2-(фенил)этил]-2-азабицикло[2.2.1]гептан-3-карбоксамидные ингибиторы катепсина с

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Publication number
EA201400358A1
EA201400358A1 EA201400358A EA201400358A EA201400358A1 EA 201400358 A1 EA201400358 A1 EA 201400358A1 EA 201400358 A EA201400358 A EA 201400358A EA 201400358 A EA201400358 A EA 201400358A EA 201400358 A1 EA201400358 A1 EA 201400358A1
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EA
Eurasian Patent Office
Prior art keywords
azabicyclo
cyano
phenyl
ethyl
katepsin
Prior art date
Application number
EA201400358A
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English (en)
Other versions
EA024817B1 (ru
Inventor
Марк Грундль
Торстен Ост
Александер Пауч
Штефан Петерс
Дорис Ритер
Вольфганг Винен
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Publication of EA201400358A1 publication Critical patent/EA201400358A1/ru
Publication of EA024817B1 publication Critical patent/EA024817B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

В заявке описаны N-1-циано-2-(фенил)этил)-2-азабицикло[2.2.1]гептан-3-карбоксамиды формулы Iи их применение в качестве ингибиторов катепсина С, фармацевтические композиции, содержащие эти соединения, и способы применения этих соединений в качестве средств для лечения и/или предупреждения респираторных заболеваний.
EA201400358A 2011-09-19 2012-09-18 Замещенные n-[1-циано-2-(фенил)этил]-2- азабицикло[2.2.1]гептан-3-карбоксамидные ингибиторы катепсина с EA024817B1 (ru)

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EP11181805 2011-09-19
PCT/EP2012/068284 WO2013041497A1 (en) 2011-09-19 2012-09-18 Substituted n- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin c

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