MX2014003080A - Inhibidores sustituidos de n-[1-ciano-2- (fenil) etil]-2-azabiciclo[2.2.1] heptan-3-carboxamida de catepsina c. - Google Patents
Inhibidores sustituidos de n-[1-ciano-2- (fenil) etil]-2-azabiciclo[2.2.1] heptan-3-carboxamida de catepsina c.Info
- Publication number
- MX2014003080A MX2014003080A MX2014003080A MX2014003080A MX2014003080A MX 2014003080 A MX2014003080 A MX 2014003080A MX 2014003080 A MX2014003080 A MX 2014003080A MX 2014003080 A MX2014003080 A MX 2014003080A MX 2014003080 A MX2014003080 A MX 2014003080A
- Authority
- MX
- Mexico
- Prior art keywords
- cathepsin
- azabicyclo
- heptane
- cyano
- phenyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000005600 Cathepsins Human genes 0.000 title 1
- 108010084457 Cathepsins Proteins 0.000 title 1
- 102000003902 Cathepsin C Human genes 0.000 abstract 1
- 108090000267 Cathepsin C Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract
Esta invención se refiere a N-1-ciano-2-(fenil)etil)-2-azabiciclo[ 2.2.1]heptan-3-carboxamidas de la fórmula I (ver Fórmula) y a su uso como inhibidores de catepsina C, composiciones farmacéuticas que las contienen y métodos de uso de ellas como agentes para el tratamiento y/o la prevención de enfermedades respiratorias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11181805 | 2011-09-19 | ||
PCT/EP2012/068284 WO2013041497A1 (en) | 2011-09-19 | 2012-09-18 | Substituted n- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin c |
Publications (2)
Publication Number | Publication Date |
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MX2014003080A true MX2014003080A (es) | 2014-04-25 |
MX335941B MX335941B (es) | 2016-01-04 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MX2014003080A MX335941B (es) | 2011-09-19 | 2012-09-18 | Inhibidores sustituidos de n-[1-ciano-2- (fenil) etil]-2-azabiciclo[2.2.1] heptan-3-carboxamida de catepsina c. |
Country Status (15)
Country | Link |
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US (1) | US8999975B2 (es) |
EP (1) | EP2758398B1 (es) |
JP (1) | JP6012736B2 (es) |
KR (1) | KR20140078626A (es) |
CN (1) | CN103814028B (es) |
AR (1) | AR087913A1 (es) |
AU (1) | AU2012311656B2 (es) |
BR (1) | BR112014006297A2 (es) |
CA (1) | CA2848929A1 (es) |
CL (1) | CL2014000299A1 (es) |
EA (1) | EA024817B1 (es) |
IL (1) | IL230820A (es) |
MX (1) | MX335941B (es) |
NZ (1) | NZ620208A (es) |
WO (1) | WO2013041497A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
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US20150307459A1 (en) | 2012-11-27 | 2015-10-29 | Basf Se | Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol Compounds and Their Use as Fungicides |
EP2928873A1 (en) | 2012-11-27 | 2015-10-14 | Basf Se | Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds and their use as fungicides |
EP2925732A1 (en) | 2012-11-27 | 2015-10-07 | Basf Se | Substituted [1,2,4]triazole compounds |
WO2014140078A1 (en) | 2013-03-14 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides inhibitors of cathepsin c |
ES2845473T3 (es) * | 2013-03-14 | 2021-07-26 | Boehringer Ingelheim Int | (Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C |
US8877775B2 (en) | 2013-03-14 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C |
EP2970230B1 (en) | 2013-03-14 | 2019-05-22 | Boehringer Ingelheim International GmbH | Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
ES2864349T3 (es) * | 2013-06-11 | 2021-10-13 | Receptos Llc | Nuevos moduladores del receptor GLP-1 |
WO2015032942A1 (en) * | 2013-09-09 | 2015-03-12 | Prozymex A/S | N-substituted 3,3'-(biphenyl-4,4'-diyl)bis-2-aminopropanenitriles as dppi inhibitors |
CA2923484C (en) * | 2013-09-09 | 2022-09-06 | Prozymex A/S | Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors |
NO2699580T3 (es) | 2014-01-24 | 2018-02-24 | ||
AR100743A1 (es) | 2014-06-06 | 2016-10-26 | Basf Se | Compuestos de [1,2,4]triazol sustituido |
JP6529575B2 (ja) * | 2014-08-01 | 2019-06-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換オキセタンおよびそれらのカテプシンcの阻害薬としての使用 |
WO2016038007A1 (en) * | 2014-09-12 | 2016-03-17 | Boehringer Ingelheim International Gmbh | Spirocyclic inhibitors of cathepsin c |
EP3265452B1 (en) | 2015-03-05 | 2020-03-04 | Neuprozyme Therapeutics ApS | Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors |
WO2016139355A1 (en) | 2015-03-05 | 2016-09-09 | Prozymex A/S | N-substituted 3,3'-(biphenyl-4,4'-diyl)bis-2-aminopropanenitriles as dppi inhibitors |
JP2021530525A (ja) | 2018-07-17 | 2021-11-11 | インスメッド インコーポレイテッド | ループス腎炎を処置するための特定の(2s)−n−[(1s)−1−シアノ−2−フェニルエチル]−1,4−オキサゼパン−2−カルボキサミド |
WO2020251972A1 (en) * | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
BR112022012410A2 (pt) | 2019-12-23 | 2022-08-30 | Kymera Therapeutics Inc | Degradadores smarca e usos dos mesmos |
JP2023535332A (ja) * | 2020-07-20 | 2023-08-17 | インスメッド インコーポレイテッド | 好中球セリンプロテアーゼを抽出するおよびジペプチジルペプチダーゼ1媒介性病態を治療するための方法 |
IL300855A (en) | 2020-08-26 | 2023-04-01 | Haisco Pharmaceuticals Pte Ltd | A nitrile derivative acting as an inhibitor of DIPEPTIDYL PEPTIDASE 1 and its use |
KR20230117738A (ko) | 2020-12-04 | 2023-08-09 | 레이스톤 바이오파마 컴퍼니 리미티드 | 카텝신 c의 소분자 억제제 및 이의 의약적 용도 |
WO2023236877A1 (zh) * | 2022-06-07 | 2023-12-14 | 瑞石生物医药有限公司 | 苯并[c]色满化合物的可药用盐、其多晶型及用途 |
WO2024094208A1 (zh) * | 2022-11-04 | 2024-05-10 | 南京明德新药研发有限公司 | 含氰基取代的杂环类衍生物及其制备方法 |
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US6960597B2 (en) * | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
DE60229114D1 (en) * | 2001-03-02 | 2008-11-13 | Axys Pharm Inc | Cathepsincystein-proteasehemmer |
WO2004110988A1 (en) | 2003-06-18 | 2004-12-23 | Prozymex A/S | Protease inhibitors |
TW200528440A (en) * | 2003-10-31 | 2005-09-01 | Fujisawa Pharmaceutical Co | 2-cyanopyrrolidinecarboxamide compound |
WO2006096807A1 (en) * | 2005-03-08 | 2006-09-14 | Janssen Pharmaceutica N.V. | Aza-bridged-bicyclic amino acid derivatives as alpha 4 integrin antagonists |
CA2706679A1 (en) * | 2007-12-12 | 2009-06-18 | Astrazeneca Ab | Novel compounds 010 |
WO2010142985A1 (en) | 2009-06-10 | 2010-12-16 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761 |
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- 2012-09-18 NZ NZ620208A patent/NZ620208A/en not_active IP Right Cessation
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- 2014-02-06 CL CL2014000299A patent/CL2014000299A1/es unknown
Also Published As
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JP6012736B2 (ja) | 2016-10-25 |
NZ620208A (en) | 2015-10-30 |
US20130172327A1 (en) | 2013-07-04 |
WO2013041497A1 (en) | 2013-03-28 |
US8999975B2 (en) | 2015-04-07 |
KR20140078626A (ko) | 2014-06-25 |
EA201400358A1 (ru) | 2014-09-30 |
EP2758398B1 (en) | 2017-08-02 |
AR087913A1 (es) | 2014-04-23 |
CN103814028B (zh) | 2016-02-17 |
MX335941B (es) | 2016-01-04 |
IL230820A0 (en) | 2014-03-31 |
JP2014526492A (ja) | 2014-10-06 |
CL2014000299A1 (es) | 2014-09-26 |
BR112014006297A2 (pt) | 2017-04-11 |
CA2848929A1 (en) | 2013-03-28 |
EP2758398A1 (en) | 2014-07-30 |
EA024817B1 (ru) | 2016-10-31 |
IL230820A (en) | 2017-03-30 |
AU2012311656A1 (en) | 2014-02-13 |
CN103814028A (zh) | 2014-05-21 |
AU2012311656B2 (en) | 2016-10-06 |
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