BR112022012410A2 - Degradadores smarca e usos dos mesmos - Google Patents

Degradadores smarca e usos dos mesmos

Info

Publication number
BR112022012410A2
BR112022012410A2 BR112022012410A BR112022012410A BR112022012410A2 BR 112022012410 A2 BR112022012410 A2 BR 112022012410A2 BR 112022012410 A BR112022012410 A BR 112022012410A BR 112022012410 A BR112022012410 A BR 112022012410A BR 112022012410 A2 BR112022012410 A2 BR 112022012410A2
Authority
BR
Brazil
Prior art keywords
degradators
smarca
compositions
compounds
methods
Prior art date
Application number
BR112022012410A
Other languages
English (en)
Inventor
Zhang Yi
R Fleming Paul
Zhu Xiao
Original Assignee
Kymera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kymera Therapeutics Inc filed Critical Kymera Therapeutics Inc
Publication of BR112022012410A2 publication Critical patent/BR112022012410A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Abstract

DEGRADADORES SMARCA E USOS DOS MESMOS. A presente invenção refere-se a compostos, composições dos mesmos e métodos de uso dos mesmos.
BR112022012410A 2019-12-23 2020-12-23 Degradadores smarca e usos dos mesmos BR112022012410A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962952578P 2019-12-23 2019-12-23
US202063123176P 2020-12-09 2020-12-09
PCT/US2020/066864 WO2021133920A1 (en) 2019-12-23 2020-12-23 Smarca degraders and uses thereof

Publications (1)

Publication Number Publication Date
BR112022012410A2 true BR112022012410A2 (pt) 2022-08-30

Family

ID=76575133

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022012410A BR112022012410A2 (pt) 2019-12-23 2020-12-23 Degradadores smarca e usos dos mesmos

Country Status (13)

Country Link
US (2) US11679109B2 (pt)
EP (1) EP4081308A4 (pt)
JP (1) JP2023509394A (pt)
KR (1) KR20220151160A (pt)
CN (1) CN115297931A (pt)
AU (1) AU2020412780A1 (pt)
BR (1) BR112022012410A2 (pt)
CA (1) CA3162502A1 (pt)
CO (1) CO2022008662A2 (pt)
IL (1) IL294150A (pt)
MX (1) MX2022007841A (pt)
TW (1) TW202136242A (pt)
WO (1) WO2021133920A1 (pt)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
WO2021252666A1 (en) * 2020-06-09 2021-12-16 Prelude Therapeutics, Incorporated Brm targeting compounds and associated methods of use
WO2023093728A1 (zh) * 2021-11-23 2023-06-01 江苏先声药业有限公司 Brm选择性降解剂化合物及其应用
WO2024056005A1 (zh) * 2022-09-14 2024-03-21 先声再明医药有限公司 多并环类化合物及其用途
WO2024064328A1 (en) 2022-09-23 2024-03-28 Regents Of The University Of Michigan Compounds and compositions as smarca2/4 degraders and uses thereof
WO2024064316A1 (en) 2022-09-23 2024-03-28 Regents Of The University Of Michigan Compounds and compositions as smarca2/4 inhibitors and uses thereof

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