GB201311910D0 - Novel Compounds - Google Patents

Novel Compounds

Info

Publication number
GB201311910D0
GB201311910D0 GBGB1311910.2A GB201311910A GB201311910D0 GB 201311910 D0 GB201311910 D0 GB 201311910D0 GB 201311910 A GB201311910 A GB 201311910A GB 201311910 D0 GB201311910 D0 GB 201311910D0
Authority
GB
United Kingdom
Prior art keywords
novel compounds
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1311910.2A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Priority to GBGB1311910.2A priority Critical patent/GB201311910D0/en
Publication of GB201311910D0 publication Critical patent/GB201311910D0/en
Priority to PCT/EP2014/050267 priority patent/WO2014108452A1/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
GBGB1311910.2A 2013-01-11 2013-07-03 Novel Compounds Ceased GB201311910D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB1311910.2A GB201311910D0 (en) 2013-07-03 2013-07-03 Novel Compounds
PCT/EP2014/050267 WO2014108452A1 (en) 2013-01-11 2014-01-09 Proteolysis targeting chimeras (protacs) directed to the modulation of the estrogen receptor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1311910.2A GB201311910D0 (en) 2013-07-03 2013-07-03 Novel Compounds

Publications (1)

Publication Number Publication Date
GB201311910D0 true GB201311910D0 (en) 2013-08-14

Family

ID=48999435

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1311910.2A Ceased GB201311910D0 (en) 2013-01-11 2013-07-03 Novel Compounds

Country Status (2)

Country Link
GB (1) GB201311910D0 (en)
WO (1) WO2014108452A1 (en)

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AU2015292710A1 (en) 2014-07-22 2017-02-16 Bioventures, Llc. Compositions and methods for selectively depleting senescent cells
US10071164B2 (en) 2014-08-11 2018-09-11 Yale University Estrogen-related receptor alpha based protac compounds and associated methods of use
WO2016118666A1 (en) 2015-01-20 2016-07-28 Arvinas, Inc. Compounds and methods for the targeted degradation of the androgen receptor
US20170327469A1 (en) 2015-01-20 2017-11-16 Arvinas, Inc. Compounds and methods for the targeted degradation of androgen receptor
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BR112017019751A2 (en) 2015-03-18 2018-05-29 Arvinas Inc bifunctional compound, pharmaceutical composition, and methods for treating or preventing a disease or disorder, and for degrading a target protein in a cell
US20180147202A1 (en) 2015-06-05 2018-05-31 Arvinas, Inc. TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE
US10772962B2 (en) 2015-08-19 2020-09-15 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
WO2017079267A1 (en) 2015-11-02 2017-05-11 Yale University Proteolysis targeting chimera compounds and methods of preparing and using same
KR102447884B1 (en) 2016-04-21 2022-09-27 바이오벤처스, 엘엘씨 Compounds inducing degradation of anti-apoptotic BCL-2 family proteins and uses thereof
GB201610156D0 (en) 2016-06-10 2016-07-27 Otsuka Pharma Co Ltd Cliptac compositions
AU2017313085A1 (en) 2016-08-19 2019-03-14 Beigene Switzerland Gmbh Use of a combination comprising a Btk inhibitor for treating cancers
CA3087528C (en) 2016-09-15 2024-01-30 Arvinas, Inc. Indole derivatives as estrogen receptor degraders
JP6899993B2 (en) * 2016-10-04 2021-07-07 国立医薬品食品衛生研究所長 Heterocyclic compound
KR102173463B1 (en) 2016-10-11 2020-11-04 아비나스 오퍼레이션스, 인코포레이티드 Compounds and methods for the targeted degradation of androgen receptor
US11458123B2 (en) 2016-11-01 2022-10-04 Arvinas Operations, Inc. Tau-protein targeting PROTACs and associated methods of use
KR20190082989A (en) 2016-12-01 2019-07-10 아비나스 오퍼레이션스, 인코포레이티드 Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor release
US11173211B2 (en) 2016-12-23 2021-11-16 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
AU2017382406A1 (en) 2016-12-23 2019-04-18 Arvinas Operations, Inc. EGFR proteolysis targeting chimeric molecules and associated methods of use
MX2019007649A (en) 2016-12-23 2019-09-10 Arvinas Operations Inc Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides.
EP3559006A4 (en) 2016-12-23 2021-03-03 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
CN117551089A (en) 2017-01-26 2024-02-13 阿尔维纳斯运营股份有限公司 Estrogen receptor proteolytic modulators and related methods of use
CA3066518A1 (en) 2017-06-26 2019-01-03 Beigene, Ltd. Immunotherapy for hepatocellular carcinoma
US11358948B2 (en) 2017-09-22 2022-06-14 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
IL307995A (en) 2017-09-22 2023-12-01 Kymera Therapeutics Inc Protein degraders and uses thereof
WO2019099926A1 (en) 2017-11-17 2019-05-23 Arvinas, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
WO2019108795A1 (en) 2017-11-29 2019-06-06 Beigene Switzerland Gmbh Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors
WO2019114770A1 (en) * 2017-12-13 2019-06-20 上海科技大学 Alk protein degradation agent and anti-tumor application thereof
US10519152B2 (en) 2017-12-21 2019-12-31 Astrazeneca Ab Compounds and their use in treating cancer
MX2020006812A (en) 2017-12-26 2020-11-06 Kymera Therapeutics Inc Irak degraders and uses thereof.
EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
US11220515B2 (en) 2018-01-26 2022-01-11 Yale University Imide-based modulators of proteolysis and associated methods of use
CN112218859A (en) 2018-04-04 2021-01-12 阿尔维纳斯运营股份有限公司 Modulators of proteolysis and related methods of use
US11667621B2 (en) 2018-06-11 2023-06-06 Stevens Institute Of Technology Antiestrogen compounds
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
JPWO2020027225A1 (en) 2018-07-31 2021-11-11 ファイメクス株式会社 Heterocyclic compound
JP7297053B2 (en) 2018-08-20 2023-06-23 アルビナス・オペレーションズ・インコーポレイテッド Alpha-Synuclein Protein-Targeted Proteolysis Targeting Chimeric (PROTAC) Compounds with E3 Ubiquitin Ligase Binding Activity to Treat Neurodegenerative Diseases
US11352350B2 (en) 2018-11-30 2022-06-07 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
US20220160890A1 (en) 2019-02-21 2022-05-26 Locki Therapeutics Limited Survival-targeting chimeric (surtac) molecules
KR20220006139A (en) 2019-04-05 2022-01-14 카이메라 쎄라퓨틱스 인코포레이티드 STAT degradation agents and uses thereof
JP2022532342A (en) 2019-05-14 2022-07-14 ニューベイション・バイオ・インコーポレイテッド Anti-cancer nuclear hormone receptor targeting compound
KR20220032063A (en) 2019-06-28 2022-03-15 카이메라 쎄라퓨틱스 인코포레이티드 IRAK disintegrants and uses thereof
US11912699B2 (en) 2019-07-17 2024-02-27 Arvinas Operations, Inc. Tau-protein targeting compounds and associated
WO2021097046A1 (en) 2019-11-13 2021-05-20 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
IL293917A (en) 2019-12-17 2022-08-01 Kymera Therapeutics Inc Irak degraders and uses thereof
TW202136240A (en) 2019-12-19 2021-10-01 美商亞文納營運公司 Compounds and methods for the targeted degradation of androgen receptor
CA3162502A1 (en) 2019-12-23 2021-07-01 Yi Zhang Smarca degraders and uses thereof
EP4121043A1 (en) 2020-03-19 2023-01-25 Kymera Therapeutics, Inc. Mdm2 degraders and uses thereof
TW202210483A (en) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Crystalline forms of irak degraders
CN112094307A (en) * 2020-09-28 2020-12-18 深圳市术理科技有限公司 Compound for target ubiquitination degradation of ER alpha protein and application thereof
WO2022120355A1 (en) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead degraders and uses thereof
IL306010A (en) 2021-03-23 2023-11-01 Nuvation Bio Inc Anti-cancer nuclear hormone receptor-targeting compounds
WO2023076161A1 (en) 2021-10-25 2023-05-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
WO2024050016A1 (en) 2022-08-31 2024-03-07 Oerth Bio Llc Compositions and methods for targeted inhibition and degradation of proteins in an insect cell
WO2024054591A1 (en) 2022-09-07 2024-03-14 Arvinas Operations, Inc. Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use
WO2024064358A1 (en) 2022-09-23 2024-03-28 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity

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Publication number Priority date Publication date Assignee Title
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
WO2012054110A2 (en) 2010-07-07 2012-04-26 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN117736134A (en) * 2012-01-12 2024-03-22 耶鲁大学 Compounds and methods for enhancing degradation of target proteins and other polypeptides by E3 ubiquitin ligases

Also Published As

Publication number Publication date
WO2014108452A1 (en) 2014-07-17

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)