BR112022012410A2 - SMARCA DEGRADATORS AND USE THEREOF - Google Patents

SMARCA DEGRADATORS AND USE THEREOF

Info

Publication number
BR112022012410A2
BR112022012410A2 BR112022012410A BR112022012410A BR112022012410A2 BR 112022012410 A2 BR112022012410 A2 BR 112022012410A2 BR 112022012410 A BR112022012410 A BR 112022012410A BR 112022012410 A BR112022012410 A BR 112022012410A BR 112022012410 A2 BR112022012410 A2 BR 112022012410A2
Authority
BR
Brazil
Prior art keywords
degradators
smarca
compositions
compounds
methods
Prior art date
Application number
BR112022012410A
Other languages
Portuguese (pt)
Inventor
Zhang Yi
R Fleming Paul
Zhu Xiao
Original Assignee
Kymera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kymera Therapeutics Inc filed Critical Kymera Therapeutics Inc
Publication of BR112022012410A2 publication Critical patent/BR112022012410A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Abstract

DEGRADADORES SMARCA E USOS DOS MESMOS. A presente invenção refere-se a compostos, composições dos mesmos e métodos de uso dos mesmos.SMARCA DEGRADATORS AND USES THEREOF. The present invention relates to compounds, compositions thereof and methods of using them.

BR112022012410A 2019-12-23 2020-12-23 SMARCA DEGRADATORS AND USE THEREOF BR112022012410A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962952578P 2019-12-23 2019-12-23
US202063123176P 2020-12-09 2020-12-09
PCT/US2020/066864 WO2021133920A1 (en) 2019-12-23 2020-12-23 Smarca degraders and uses thereof

Publications (1)

Publication Number Publication Date
BR112022012410A2 true BR112022012410A2 (en) 2022-08-30

Family

ID=76575133

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022012410A BR112022012410A2 (en) 2019-12-23 2020-12-23 SMARCA DEGRADATORS AND USE THEREOF

Country Status (13)

Country Link
US (1) US11679109B2 (en)
EP (1) EP4081308A1 (en)
JP (1) JP2023509394A (en)
KR (1) KR20220151160A (en)
CN (1) CN115297931A (en)
AU (1) AU2020412780A1 (en)
BR (1) BR112022012410A2 (en)
CA (1) CA3162502A1 (en)
CO (1) CO2022008662A2 (en)
IL (1) IL294150A (en)
MX (1) MX2022007841A (en)
TW (1) TW202136242A (en)
WO (1) WO2021133920A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL298933A (en) 2020-06-09 2023-02-01 Prelude Therapeutics Inc Brm targeting compounds and associated methods of use
WO2023093728A1 (en) * 2021-11-23 2023-06-01 江苏先声药业有限公司 Brm selective degradation agent compound and use thereof

Family Cites Families (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4709016A (en) 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5516931A (en) 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US4650750A (en) 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US5217866A (en) 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
US5360811A (en) 1990-03-13 1994-11-01 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
JP3545461B2 (en) 1993-09-10 2004-07-21 エーザイ株式会社 Bicyclic heterocycle-containing sulfonamide derivatives
AU4596096A (en) 1994-09-06 1996-03-27 Banyu Pharmaceutical Co., Ltd. Novel carbapenem derivative
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US6306663B1 (en) 1999-02-12 2001-10-23 Proteinex, Inc. Controlling protein levels in eucaryotic organisms
HU229671B1 (en) 1999-12-10 2014-04-28 Pfizer Prod Inc Pyrrolo[2,3-d]pirimidine compounds
DE10002509A1 (en) 2000-01-21 2001-07-26 Gruenenthal Gmbh New substituted glutarimide derivatives are IL-12 antagonists, are useful as immunomodulators and for the treatment of angiopathy, hematological or oncological disorders
DE60111358T2 (en) 2000-02-28 2006-05-11 Sugen, Inc., San Diego 3- (PYROLYL LACTON) -2-INDOLINONE COMPOUNDS FOR USE AS KINASE-INHIBITORS
PE20020354A1 (en) 2000-09-01 2002-06-12 Novartis Ag HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS
US7041298B2 (en) 2000-09-08 2006-05-09 California Institute Of Technology Proteolysis targeting chimeric pharmaceutical
US7208157B2 (en) 2000-09-08 2007-04-24 California Institute Of Technology Proteolysis targeting chimeric pharmaceutical
ATE350376T1 (en) 2001-04-27 2007-01-15 Zenyaku Kogyo Kk HETEROCYCLIC COMPOUND AND ANTITUMOR AGENT CONTAINING THE SAME AS AN ACTIVE INGREDIENT
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
PT1536827E (en) 2002-08-14 2009-03-20 Silence Therapeutics Ag Use of protein kinase n beta
NZ542475A (en) 2003-04-03 2009-04-30 Semafore Pharmaceuticals Inc PI-3 kinase inhibitor prodrugs
WO2004106328A1 (en) 2003-05-30 2004-12-09 Gemin X Biotechnologies Inc. Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
JP2007524397A (en) 2003-07-03 2007-08-30 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア Inhibition of SYK kinase expression
EP1761540B1 (en) 2004-05-13 2016-09-28 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
JP4801096B2 (en) 2005-01-19 2011-10-26 ライジェル ファーマシューティカルズ， インコーポレイテッド Prodrugs of 2,4-pyrimidinediamine compounds and their use
PT2343320T (en) 2005-03-25 2018-01-23 Gitr Inc Anti-gitr antibodies and uses thereof
CN101175738B (en) 2005-05-12 2010-10-27 雅培制药有限公司 Apoptosis promoters
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
HUE026039T2 (en) 2005-07-01 2016-05-30 Squibb & Sons Llc Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
US7402325B2 (en) 2005-07-28 2008-07-22 Phoenix Biotechnology, Inc. Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
CN101282948A (en) 2005-10-07 2008-10-08 埃克塞里艾克西斯公司 Phosphatidylinositol 3-kinase inhibitors and methods of their use
US7528143B2 (en) 2005-11-01 2009-05-05 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
LT2426129T (en) 2005-12-13 2017-02-10 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
US7622496B2 (en) 2005-12-23 2009-11-24 Zealand Pharma A/S Modified lysine-mimetic compounds
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي PI-3 Kinase inhibitors and methods of their use
AR060631A1 (en) 2006-04-26 2008-07-02 Piramed Ltd DERIVATIVES OF PIRIMIDINE AND ITS USE AS INHIBITORS OF PHOSFATIDYLNOSITOL 3-QUINASE (PI3K)
ES2564647T3 (en) 2006-09-22 2016-03-28 Pharmacyclics Llc Bruton tyrosine kinase inhibitors
CN101861313B (en) 2007-03-12 2014-06-04 Ym生物科学澳大利亚私人有限公司 Phenyl amino pyrimidine compounds and uses thereof
WO2008118802A1 (en) 2007-03-23 2008-10-02 Regents Of The University Of Minnesota Therapeutic compounds
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
PE20090717A1 (en) 2007-05-18 2009-07-18 Smithkline Beecham Corp QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS
EP2175884B8 (en) 2007-07-12 2017-02-22 GITR, Inc. Combination therapies employing gitr binding molecules
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
JP2011514881A (en) 2007-11-09 2011-05-12 ザ ソルク インスティテュート フォー バイオロジカル スタディーズ Use of TAM receptor inhibitors as immunopotentiators and use of TAM activators as immunosuppressants
CA2707308C (en) 2007-11-30 2016-08-02 Newlink Genetics Corporation Ido inhibitors
NZ587928A (en) 2008-03-11 2012-08-31 Incyte Corp Azetidine and cyclobutane derivatives as jak inhibitors
EP2291187B1 (en) 2008-04-24 2018-08-15 Newlink Genetics Corporation Ido inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
MX356367B (en) 2008-12-09 2018-05-25 Genentech Inc Anti-pd-l1 antibodies and their use to enhance t-cell function.
US8921037B2 (en) 2008-12-16 2014-12-30 Bo Han PF4-depleted platelet rich plasma preparations and methods for hard and soft tissue repair
PT3023438T (en) 2009-09-03 2020-05-08 Merck Sharp & Dohme Anti-gitr antibodies
ES2601226T3 (en) 2009-10-28 2017-02-14 Newlink Genetics Corporation Imidazole derivatives as IDO inhibitors
TWI422388B (en) 2009-12-10 2014-01-11 Hoffmann La Roche Antibodies against human csf-1r and uses thereof
MY156358A (en) 2010-03-04 2016-02-15 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
KR101656548B1 (en) 2010-03-05 2016-09-09 에프. 호프만-라 로슈 아게 Antibodies against human csf-1r and uses thereof
RU2617966C2 (en) 2010-03-05 2017-04-28 Ф.Хоффманн-Ля Рош Аг Antibodies to human csf-1r and use thereof
US8114621B2 (en) 2010-03-12 2012-02-14 Saladax Biomedical Inc. Lenalidomide and thalidomide immunoassays
PL2566517T3 (en) 2010-05-04 2019-04-30 Five Prime Therapeutics Inc Antibodies that bind csf1r
CN103153335A (en) 2010-06-30 2013-06-12 布兰代斯大学 Small-molecule-targeted protein degradation
NZ729044A (en) 2010-09-09 2020-07-31 Pfizer 4-1bb binding molecules
CA2823837A1 (en) 2010-12-07 2012-06-14 Yale University Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same
HUE042207T2 (en) 2010-12-09 2019-06-28 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
NO2694640T3 (en) 2011-04-15 2018-03-17
US9205148B2 (en) 2011-04-20 2015-12-08 Medimmune, Llc Antibodies and other molecules that bind B7-H1 and PD-1
US8999975B2 (en) 2011-09-19 2015-04-07 Boehringer Ingelheim International Gmbh Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C
EA036814B9 (en) 2011-11-28 2021-12-27 Мерк Патент Гмбх Anti-pd-l1 antibody (embodiments), composition comprising this antibody and use thereof
BR112014012624A2 (en) 2011-12-15 2018-10-09 F Hoffmann-La Roche Ag antibodies, pharmaceutical composition, nucleic acid, expression vectors, host cell, method for producing a recombinant antibody and use of the antibody
JP2015508414A (en) 2012-01-12 2015-03-19 イエール ユニバーシティ Compounds and methods for enhanced degradation of target proteins and other polypeptides by E3 ubiquitin ligase
WO2013106646A2 (en) 2012-01-12 2013-07-18 Yale University Compounds and methods for the inhibition of vcb e3 ubiquitin ligase
WO2013119716A1 (en) 2012-02-06 2013-08-15 Genentech, Inc. Compositions and methods for using csf1r inhibitors
AR090263A1 (en) 2012-03-08 2014-10-29 Hoffmann La Roche COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME
BR112014028013A2 (en) 2012-05-11 2018-02-27 Five Prime Therapeutics Inc methods for treating a condition associated with rheumatoid arthritis, rheumatoid arthritis, skin lesions, lupus nephritis, lupus, an inflammatory condition, cd16 + disorder, method for reducing the number of cd16 + monocytes, methods for slowing the progression of a renal condition, rag and bone loss
AU2013261130A1 (en) 2012-05-15 2014-10-23 Novartis Ag Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
AR091649A1 (en) 2012-07-02 2015-02-18 Bristol Myers Squibb Co OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
KR102146848B1 (en) 2012-08-09 2020-08-21 셀진 코포레이션 Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
SG11201501413YA (en) 2012-08-31 2015-03-30 Five Prime Therapeutics Inc Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
CA2877188A1 (en) 2012-09-19 2014-03-27 F. Hoffmann-La Roche Ag 2-oxo-2,3,4,5-tetrahydro-1 h-benzo[b]diazepines and their use in the treatment of cancer
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
GB201311910D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel Compounds
US9777144B2 (en) 2013-03-15 2017-10-03 Zeon Corporation Aqueous dispersion of hollow polymer particles and method of production of same
MX2016006432A (en) 2013-11-18 2016-07-19 Hoffmann La Roche Tetrahydro-benzodiazepinones.
AU2014354711B2 (en) 2013-11-27 2018-10-25 Signalchem Lifesciences Corporation Aminopyridine derivatives as TAM family kinase inhibitors
EP3086791A4 (en) 2013-12-24 2017-06-14 University of Florida Research Foundation, Inc. Phenazine derivatives as antimicrobial agents
RU2016137674A3 (en) 2014-03-17 2018-10-10
US20160058872A1 (en) 2014-04-14 2016-03-03 Arvinas, Inc. Imide-based modulators of proteolysis and associated methods of use
JP6778114B2 (en) 2014-04-14 2020-10-28 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． Imid-based proteolysis modulators and related uses
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
ES2843973T3 (en) 2014-06-27 2021-07-21 Celgene Corp Compositions and methods to induce conformational changes in cereblon and other E3 ubiquitin ligases
US20160022642A1 (en) 2014-07-25 2016-01-28 Yale University Compounds Useful for Promoting Protein Degradation and Methods Using Same
US10071164B2 (en) 2014-08-11 2018-09-11 Yale University Estrogen-related receptor alpha based protac compounds and associated methods of use
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2016105518A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
US20170327469A1 (en) 2015-01-20 2017-11-16 Arvinas, Inc. Compounds and methods for the targeted degradation of androgen receptor
AU2016209349B2 (en) 2015-01-20 2020-05-07 Arvinas, Inc. Compounds and methods for the targeted degradation of the Androgen Receptor
MA41598A (en) 2015-02-25 2018-01-02 Constellation Pharmaceuticals Inc PYRIDAZINE THERAPEUTIC COMPOUNDS AND THEIR USES
KR20180011759A (en) 2015-03-18 2018-02-02 아비나스 인코포레이티드 Compounds and methods for improved degradation of targeted proteins
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
RU2704807C9 (en) 2015-06-04 2021-02-24 Арвинас, Инк. Imides based proteolysis modulators and related methods of use
EP3302482A4 (en) 2015-06-05 2018-12-19 Arvinas, Inc. Tank-binding kinase-1 protacs and associated methods of use
CN105085620B (en) 2015-06-25 2018-05-08 中山大学附属第一医院 A kind of compound for targeting ubiquitination degraded Smad3
WO2017007612A1 (en) 2015-07-07 2017-01-12 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
EP3319944A4 (en) 2015-07-10 2019-04-24 Arvinas, Inc. Mdm2-based modulators of proteolysis and associated methods of use
EP3322986A4 (en) 2015-07-13 2018-09-05 Arvinas, Inc. Alanine-based modulators of proteolysis and associated methods of use
CN107849013B (en) 2015-07-14 2022-03-29 特殊治疗有限公司 Cyanopyrrolidines as DUB inhibitors for the treatment of cancer
WO2017024317A2 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2017030814A1 (en) 2015-08-19 2017-02-23 Arvinas, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
WO2017059280A1 (en) 2015-10-02 2017-04-06 The University Of North Carolina At Chapel Hill Novel pan-tam inhibitors and mer/axl dual inhibitors
CA3002709A1 (en) 2015-11-02 2017-05-11 Yale University Proteolysis targeting chimera compounds and methods of preparing and using same
WO2017117473A1 (en) 2015-12-30 2017-07-06 Dana-Farber Cancer Institute, Inc. Bifunctional molescules for her3 degradation and methods of use
US20190016703A1 (en) 2015-12-30 2019-01-17 Dana-Farber Cancer Institute, Inc. Bifunctional compounds for her3 degradation and methods of use
KR20170101128A (en) 2016-02-26 2017-09-05 가부시키가이샤 한도오따이 에네루기 켄큐쇼 Organic compound, light-emitting element, light-emitting device, electronic device, and lighting device
US11395820B2 (en) 2016-03-16 2022-07-26 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small molecules against cereblon to enhance effector t cell function
US20170281784A1 (en) 2016-04-05 2017-10-05 Arvinas, Inc. Protein-protein interaction inducing technology
BR112018070549A2 (en) 2016-04-06 2019-02-12 The Regents Of The University Of Michigan mdm2 protein degradants
US10759808B2 (en) 2016-04-06 2020-09-01 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
EP3454856A4 (en) 2016-05-10 2019-12-25 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
WO2017201069A1 (en) 2016-05-18 2017-11-23 Biotheryx, Inc. Oxoindoline derivatives as protein function modulators
JP2019522633A (en) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド PROTAC antibody conjugates and methods of use
GB201610147D0 (en) 2016-06-10 2016-07-27 Glaxosmithkline Ip Dev Ltd Novel compounds
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
WO2018089736A1 (en) 2016-11-10 2018-05-17 Dana-Farber Cancer Institute, Inc. Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use
JP7308146B2 (en) 2016-11-22 2023-07-13 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE AND USES THEREOF
KR20190116315A (en) 2017-01-31 2019-10-14 아비나스 오퍼레이션스, 인코포레이티드 Cereblon Ligand and Bifunctional Compounds Comprising the Same
WO2018216204A1 (en) 2017-05-26 2018-11-29 オリンパス株式会社 Master-slave manipulator and method for controlling same
WO2018237026A1 (en) 2017-06-20 2018-12-27 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
EP3679026A1 (en) 2017-09-04 2020-07-15 C4 Therapeutics, Inc. Glutarimide
IL295603B1 (en) 2017-09-22 2023-11-01 Kymera Therapeutics Inc Protein degraders and uses thereof
US11358948B2 (en) 2017-09-22 2022-06-14 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
EP3700901A1 (en) 2017-10-24 2020-09-02 Genentech, Inc. (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
WO2019084030A1 (en) 2017-10-24 2019-05-02 Genentech, Inc. (4-hydroxypyrrolidin-2-yl)-hydroxamate compounds and methods of use thereof
CN111372585A (en) 2017-11-16 2020-07-03 C4医药公司 Degradants and degreddeterminants for target protein degradation
EP3710443A1 (en) 2017-11-17 2020-09-23 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
WO2019133531A1 (en) 2017-12-26 2019-07-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
EP3746124A4 (en) 2018-01-30 2021-10-27 Foghorn Therapeutics Inc. Compounds and uses thereof
EP3755325A4 (en) 2018-02-23 2022-03-02 Dana-Farber Cancer Institute, Inc. Small molecules for inducing selective protein degradation and uses thereof
PE20212108A1 (en) * 2018-04-01 2021-11-04 Arvinas Operations Inc BRM TARGETED COMPOUNDS AND ASSOCIATED METHODS OF USE
CA3093405A1 (en) 2018-04-30 2019-11-07 Dana-Farber Cancer Institute, Inc. Small molecule degraders of polybromo-1 (pbrm1)
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
WO2020010210A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Mertk degraders and uses thereof
US20220348556A1 (en) 2018-07-06 2022-11-03 Kymera Therapeutics, Inc. Protein degraders and uses thereof
CN110858903B (en) 2018-08-22 2022-07-12 华为技术有限公司 Chroma block prediction method and device
US20210380579A1 (en) 2018-10-16 2021-12-09 Boehringer Ingelheim International Gmbh Proteolysis targeting chimera (protacs) as degraders of smarca2 and /or smarca4
WO2020160100A1 (en) 2019-01-29 2020-08-06 Foghorn Therapeutics Inc. Compounds and uses thereof
WO2020251974A1 (en) * 2019-06-10 2020-12-17 Kymera Therapeutics, Inc. Smarca inhibitors and uses thereof
US20220281831A1 (en) 2019-07-15 2022-09-08 Kymera Therapeutics, Inc. Fused-glutarimide crbn ligands and uses thereof
WO2021067606A1 (en) 2019-10-01 2021-04-08 Arvinas Operations, Inc. Brm targeting compounds and associated methods of use
WO2021086785A1 (en) 2019-10-28 2021-05-06 F. Hoffmann-La Roche Ag Bifunctional compounds
CN114728936A (en) 2019-10-29 2022-07-08 豪夫迈·罗氏有限公司 Bifunctional compounds for the treatment of cancer
MX2022008487A (en) 2020-01-10 2022-08-02 Amgen Inc Smarca2-vhl degraders.
BR112022019991A2 (en) 2020-04-06 2022-11-22 Foghorn Therapeutics Inc COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USES THEREOF
IL298933A (en) 2020-06-09 2023-02-01 Prelude Therapeutics Inc Brm targeting compounds and associated methods of use
WO2022029617A1 (en) 2020-08-04 2022-02-10 Aurigene Discovery Technologies Limited 6-substituted pyridazine compounds as smarca2 and/or smarca4 degraders

Also Published As

Publication number Publication date
US11679109B2 (en) 2023-06-20
TW202136242A (en) 2021-10-01
CN115297931A (en) 2022-11-04
CO2022008662A2 (en) 2022-07-19
WO2021133920A1 (en) 2021-07-01
AU2020412780A1 (en) 2022-07-21
US20220331317A1 (en) 2022-10-20
IL294150A (en) 2022-08-01
JP2023509394A (en) 2023-03-08
CA3162502A1 (en) 2021-07-01
EP4081308A1 (en) 2022-11-02
KR20220151160A (en) 2022-11-14
MX2022007841A (en) 2022-07-19

Similar Documents

Publication Publication Date Title
BR112021024108A2 (en) Tead inhibitors and uses thereof
BR112021024224A2 (en) Tead inhibitors and uses thereof
BR112022011651A2 (en) IRAK DEGRADATORS AND USES THEREOF
CO2021007068A2 (en) Iraq degraders and uses thereof
BR112016006319A2 (en) irak inhibitors and uses thereof
BR112022004451A2 (en) hpk1 antagonists and uses thereof
BR112017002594A2 (en) tank binding kinase inhibitor compounds
BR112019003415A2 (en) substituted pyrrolizine compounds and uses thereof
BR112018073384A2 (en) modulating polynucleotides
BR112019001607A2 (en) macrocyclic kinase inhibitors
BR112018005779A2 (en) htt repressors and uses thereof
BR112018003343A2 (en) heteroaryl compounds as irak inhibitors and their uses
BR112017002053A2 (en) compound according to formula (i), pharmaceutical composition, and uses of a compound
EA201890058A1 (en) GLUCAGON DERIVATIVE AND COMPOSITION CONTAINING A LONGERLY ACTING CONJUGATE OF THIS DERIVATIVE
BR112015028173A2 (en) acc inhibitors and uses thereof
CR20160419A (en) NEW BICYCLE COMPOUNDS
BR112017005266A2 (en) mk2 inhibitors and their use
BR112017012351A2 (en) bcl x1 inhibitor compounds that have low cell permeability and drug-antibody conjugates that include the same
BR112015011760A2 (en) compound, use of the compound, and use of a pharmaceutical composition
GT201700190A (en) DEACETOXITUBULISINE H AND ANALOGS OF THIS
CO2021013339A2 (en) Stat degraders and their uses
EA201892500A1 (en) APPLICATION OF THE LIGNIN FRACTION AS AN ANTIFYTOPATOGENIC AGENT AND CONTAINING ITS ANTIFYTOPATOGENIC COMPOSITIONS
CL2017002856A1 (en) Thioether compounds as nitrification inhibitors
UY38031A (en) HYDROXIISOXAZOLINAS AND DERIVATIVES OF THESE
BR112017028549A2 (en) pyrimidine derivatives as btk inhibitors and uses thereof