MX370666B - Novedosos moduladores del receptor de péptido tipo glucagón 1 (glp-1). - Google Patents

Novedosos moduladores del receptor de péptido tipo glucagón 1 (glp-1).

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Publication number
MX370666B
MX370666B MX2015016831A MX2015016831A MX370666B MX 370666 B MX370666 B MX 370666B MX 2015016831 A MX2015016831 A MX 2015016831A MX 2015016831 A MX2015016831 A MX 2015016831A MX 370666 B MX370666 B MX 370666B
Authority
MX
Mexico
Prior art keywords
glp
receptor modulators
novel glp
receptor
peptide
Prior art date
Application number
MX2015016831A
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English (en)
Other versions
MX2015016831A (es
Inventor
Tamiya Junko
F Boehm Marcus
Martinborough Esther
Moorjani Manisha
Huang Liming
r yeager Adam
Brahmachary Enugurthi
Fowler Thomas
Novak Andrew
Meghani Premji
Knaggs Michael
Original Assignee
Celgene Int Ii Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Int Ii Sarl filed Critical Celgene Int Ii Sarl
Publication of MX2015016831A publication Critical patent/MX2015016831A/es
Publication of MX370666B publication Critical patent/MX370666B/es

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    • C07D495/04—Ortho-condensed systems
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

Se proporcionan compuestos que modulan al receptor de péptido tipo glucagón 1 (GLP-1), así como métodos para su síntesis, y métodos de su uso terapéutico y/o profiláctico. Tales compuestos pueden actuar como moduladores o potenciadores del receptor de GLP-1 por su cuenta, o con péptidos de incretina tales como GLP-1(7-36) y GLP-1(9-36), o con terapias a base de péptidos, tales como exenatida y liraglutida, y tienen la siguiente estructura general (ver Fórmula) en (donde "(I)" representa cualquiera o ambas de la forma R y S del compuesto) : en donde A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p y q son como se definen en la presente.
MX2015016831A 2013-06-11 2014-06-11 Novedosos moduladores del receptor de péptido tipo glucagón 1 (glp-1). MX370666B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361833737P 2013-06-11 2013-06-11
US201461981643P 2014-04-18 2014-04-18
PCT/US2014/041997 WO2014201172A1 (en) 2013-06-11 2014-06-11 Novel glp-1 receptor modulators

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MX2015016831A MX2015016831A (es) 2016-04-04
MX370666B true MX370666B (es) 2019-12-19

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US (3) US9260427B2 (es)
EP (1) EP3008056B8 (es)
JP (1) JP6573604B2 (es)
KR (1) KR102271179B1 (es)
CN (2) CN109867630A (es)
AU (1) AU2014278183B2 (es)
BR (1) BR112015031040A8 (es)
CA (1) CA2913791A1 (es)
EA (1) EA030857B1 (es)
ES (1) ES2864349T3 (es)
HK (2) HK1222177A1 (es)
MX (1) MX370666B (es)
WO (1) WO2014201172A1 (es)

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