MX342164B - Derivados de pirimidina fusionados novedosos para la inhibicion de la actividad de tirosina cinasa. - Google Patents
Derivados de pirimidina fusionados novedosos para la inhibicion de la actividad de tirosina cinasa.Info
- Publication number
- MX342164B MX342164B MX2014005025A MX2014005025A MX342164B MX 342164 B MX342164 B MX 342164B MX 2014005025 A MX2014005025 A MX 2014005025A MX 2014005025 A MX2014005025 A MX 2014005025A MX 342164 B MX342164 B MX 342164B
- Authority
- MX
- Mexico
- Prior art keywords
- inhibition
- tyrosine kinase
- fused pyrimidine
- kinase activity
- novel fused
- Prior art date
Links
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title abstract 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract
La presente invención se refiere a un derivado de pirimidina fusionada novedosa que tiene una actividad inhibidora de tirosinas cinasas, y una composición farmacéutica para prevenir o tratar cánceres, tumores, enfermedades inflamatorias, enfermedades autoinmunes, o enfermedades mediadas inmunológicamente que comprenden el mismo como un ingrediente activo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20100059686 | 2010-06-23 | ||
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