MX2011012353A - Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus. - Google Patents
Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.Info
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- MX2011012353A MX2011012353A MX2011012353A MX2011012353A MX2011012353A MX 2011012353 A MX2011012353 A MX 2011012353A MX 2011012353 A MX2011012353 A MX 2011012353A MX 2011012353 A MX2011012353 A MX 2011012353A MX 2011012353 A MX2011012353 A MX 2011012353A
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- pyrimidines
- pyrrolo
- hetero
- aryl
- pyrrol
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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Abstract
La presente invención se relaciona con derivados de N-(hetero)aril-pirrolidina de Fórmula I: (ver fórmula (I)) que son inhibidores de JAK, tal como inhibidores selectivos de JAK1 ¡ útiles en el tratamiento de enfermedades asociadas con JAK, entre las que se incluyen, por ejemplo, los trastornos inflamatorios y autoinmunes y también el cáncer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18062209P | 2009-05-22 | 2009-05-22 | |
US22509209P | 2009-07-13 | 2009-07-13 | |
PCT/US2010/035783 WO2010135650A1 (en) | 2009-05-22 | 2010-05-21 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011012353A true MX2011012353A (es) | 2011-12-14 |
Family
ID=42543342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011012353A MX2011012353A (es) | 2009-05-22 | 2010-05-21 | Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus. |
Country Status (22)
Country | Link |
---|---|
US (2) | US8716303B2 (es) |
EP (1) | EP2432555B1 (es) |
JP (1) | JP5775070B2 (es) |
KR (1) | KR101771401B1 (es) |
CN (1) | CN102458581B (es) |
AR (1) | AR076794A1 (es) |
AU (1) | AU2010249380B2 (es) |
BR (1) | BRPI1012159B1 (es) |
CA (1) | CA2762174C (es) |
CL (1) | CL2011002956A1 (es) |
CO (1) | CO6440524A2 (es) |
CR (1) | CR20110620A (es) |
EA (1) | EA025520B1 (es) |
ES (1) | ES2487542T3 (es) |
IL (1) | IL216463A (es) |
MX (1) | MX2011012353A (es) |
MY (1) | MY156727A (es) |
NZ (1) | NZ596479A (es) |
SG (1) | SG176130A1 (es) |
TW (1) | TW201100429A (es) |
WO (1) | WO2010135650A1 (es) |
ZA (1) | ZA201108544B (es) |
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CR20110620A (es) | 2012-02-02 |
CA2762174A1 (en) | 2010-11-25 |
EA201171454A1 (ru) | 2012-06-29 |
NZ596479A (en) | 2014-01-31 |
KR20120034665A (ko) | 2012-04-12 |
ZA201108544B (en) | 2013-04-24 |
CN102458581B (zh) | 2016-03-30 |
IL216463A (en) | 2017-09-28 |
TW201100429A (en) | 2011-01-01 |
SG176130A1 (en) | 2011-12-29 |
ES2487542T3 (es) | 2014-08-21 |
JP5775070B2 (ja) | 2015-09-09 |
EA025520B1 (ru) | 2017-01-30 |
US9334274B2 (en) | 2016-05-10 |
AR076794A1 (es) | 2011-07-06 |
BRPI1012159A2 (pt) | 2020-09-15 |
WO2010135650A1 (en) | 2010-11-25 |
JP2012527483A (ja) | 2012-11-08 |
US20100298334A1 (en) | 2010-11-25 |
IL216463A0 (en) | 2012-02-29 |
CA2762174C (en) | 2018-02-20 |
CN102458581A (zh) | 2012-05-16 |
KR101771401B1 (ko) | 2017-08-25 |
CL2011002956A1 (es) | 2012-05-25 |
EP2432555A1 (en) | 2012-03-28 |
EP2432555B1 (en) | 2014-04-30 |
US8716303B2 (en) | 2014-05-06 |
US20140221379A1 (en) | 2014-08-07 |
MY156727A (en) | 2016-03-15 |
CO6440524A2 (es) | 2012-05-15 |
AU2010249380A1 (en) | 2011-12-08 |
AU2010249380B2 (en) | 2015-08-20 |
BRPI1012159B1 (pt) | 2022-01-25 |
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