MX2019003989A - Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados. - Google Patents

Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.

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Publication number
MX2019003989A
MX2019003989A MX2019003989A MX2019003989A MX2019003989A MX 2019003989 A MX2019003989 A MX 2019003989A MX 2019003989 A MX2019003989 A MX 2019003989A MX 2019003989 A MX2019003989 A MX 2019003989A MX 2019003989 A MX2019003989 A MX 2019003989A
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MX
Mexico
Prior art keywords
processes
intermediate compounds
jak inhibitors
related intermediate
preparing
Prior art date
Application number
MX2019003989A
Other languages
English (en)
Inventor
Pan Yongchun
Liu Pingli
Lin Qiyan
W Metcalf Brian
Meloni David
Xia Michael
Yue Tai-Yuen
D Rodgers James
Wang Haisheng
Li Mei
Zhou Jiacheng
Original Assignee
Incyte Holdings Corp
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Publication date
Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Publication of MX2019003989A publication Critical patent/MX2019003989A/es

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16Halogen atoms or nitro radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
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    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
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    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
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    • C07F5/025Boronic and borinic acid compounds
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    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
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    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
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    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
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    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
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    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • C07F7/1872Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
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    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a procesos para preparar pirazolil pirrolo[2,3-d]pirimidinas sustituidas quirales de fórmula III, y los compuestos intermediarios sintéticos relacionados. Las pirazolil pirrolo[2,3-d]pirimidinas sustituidas quirales son útiles como inhibidores de la familia Janus cinasa de las proteína tirosina cinasas (JAKs) para el tratamiento de enfermedades inflamatorias, trastornos mieloproliferativos, y otras enfermedades. (ver Fórmula).
MX2019003989A 2009-01-15 2011-06-30 Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados. MX2019003989A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14499109P 2009-01-15 2009-01-15

Publications (1)

Publication Number Publication Date
MX2019003989A true MX2019003989A (es) 2019-08-12

Family

ID=42026219

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2018009174A MX363976B (es) 2009-01-15 2010-01-14 Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.
MX2014003735A MX349632B (es) 2009-01-15 2010-01-14 Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.
MX2011007102A MX2011007102A (es) 2009-01-15 2010-01-14 Proceso para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.
MX2017005254A MX357874B (es) 2009-01-15 2010-01-14 Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.
MX2019003989A MX2019003989A (es) 2009-01-15 2011-06-30 Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.

Family Applications Before (4)

Application Number Title Priority Date Filing Date
MX2018009174A MX363976B (es) 2009-01-15 2010-01-14 Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.
MX2014003735A MX349632B (es) 2009-01-15 2010-01-14 Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.
MX2011007102A MX2011007102A (es) 2009-01-15 2010-01-14 Proceso para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.
MX2017005254A MX357874B (es) 2009-01-15 2010-01-14 Procesos para preparar inhibidores de proteinas janus cinasas (jak) y compuestos intermediarios relacionados.

Country Status (29)

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US (9) US8410265B2 (es)
EP (2) EP2398774B1 (es)
JP (6) JP5650662B2 (es)
KR (7) KR101824742B1 (es)
CN (3) CN105669675A (es)
AR (2) AR082747A1 (es)
AU (5) AU2010204772B2 (es)
BR (3) BR122020005540B8 (es)
CA (2) CA2749483C (es)
CL (3) CL2011001668A1 (es)
CO (1) CO6400137A2 (es)
EA (3) EA020643B1 (es)
EC (1) ECSP11011268A (es)
ES (1) ES2641761T3 (es)
IL (7) IL214061A (es)
JO (3) JOP20190230A1 (es)
MA (1) MA33038B1 (es)
MX (5) MX363976B (es)
MY (3) MY163540A (es)
NZ (5) NZ706894A (es)
PE (4) PE20171102A1 (es)
PH (1) PH12016502060B1 (es)
PL (1) PL2398774T3 (es)
PT (1) PT2398774T (es)
SG (3) SG10201913261QA (es)
TN (1) TN2011000329A1 (es)
TW (7) TWI740775B (es)
WO (1) WO2010083283A2 (es)
ZA (1) ZA201104909B (es)

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