SG11202010092XA - Biomarkers for graft-versus-host disease - Google Patents
Biomarkers for graft-versus-host diseaseInfo
- Publication number
- SG11202010092XA SG11202010092XA SG11202010092XA SG11202010092XA SG11202010092XA SG 11202010092X A SG11202010092X A SG 11202010092XA SG 11202010092X A SG11202010092X A SG 11202010092XA SG 11202010092X A SG11202010092X A SG 11202010092XA SG 11202010092X A SG11202010092X A SG 11202010092XA
- Authority
- SG
- Singapore
- Prior art keywords
- biomarkers
- graft
- versus
- host disease
- host
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862657193P | 2018-04-13 | 2018-04-13 | |
US201862773308P | 2018-11-30 | 2018-11-30 | |
PCT/US2019/026884 WO2019200030A1 (en) | 2018-04-13 | 2019-04-11 | Biomarkers for graft-versus-host disease |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202010092XA true SG11202010092XA (en) | 2020-11-27 |
Family
ID=66323933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202010092XA SG11202010092XA (en) | 2018-04-13 | 2019-04-11 | Biomarkers for graft-versus-host disease |
Country Status (14)
Country | Link |
---|---|
US (2) | US11372003B2 (en) |
EP (1) | EP3775923A1 (en) |
JP (1) | JP7378420B2 (en) |
KR (1) | KR20210018218A (en) |
CN (1) | CN112567247A (en) |
AU (1) | AU2019252259A1 (en) |
CA (1) | CA3097025A1 (en) |
IL (1) | IL277955A (en) |
MA (1) | MA52208A (en) |
MX (1) | MX2020010815A (en) |
PH (1) | PH12020551683A1 (en) |
SG (1) | SG11202010092XA (en) |
TW (1) | TW202012935A (en) |
WO (1) | WO2019200030A1 (en) |
Families Citing this family (11)
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SG10201703533VA (en) * | 2012-11-01 | 2017-06-29 | Incyte Corp | Tricyclic fused thiophene derivatives as jak inhibitors |
SG11202007805SA (en) | 2018-02-16 | 2020-09-29 | Incyte Corp | Jak1 pathway inhibitors for the treatment of cytokine-related disorders |
US11584961B2 (en) | 2018-03-30 | 2023-02-21 | Incyte Corporation | Biomarkers for inflammatory skin disease |
MX2020010815A (en) | 2018-04-13 | 2020-12-11 | Incyte Corp | Biomarkers for graft-versus-host disease. |
US11324749B2 (en) | 2018-10-31 | 2022-05-10 | Incyte Corporation | Combination therapy for treatment of hematological diseases |
KR20210137087A (en) | 2019-03-05 | 2021-11-17 | 인사이트 코포레이션 | JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction |
US20210123930A1 (en) * | 2019-10-10 | 2021-04-29 | Incyte Corporation | Biomarkers for graft-versus-host disease |
US20210123931A1 (en) * | 2019-10-10 | 2021-04-29 | Incyte Corporation | Biomarkers for graft-versus-host disease |
CN114829583A (en) * | 2020-02-25 | 2022-07-29 | 上海大学 | Application of mesenchymal stem cells in treatment of severe COVID19 pneumonia |
KR20230118118A (en) | 2020-12-08 | 2023-08-10 | 인사이트 코포레이션 | JAK1 pathway inhibitors for the treatment of vitiligo |
KR102378996B1 (en) * | 2021-01-13 | 2022-03-25 | 단국대학교 천안캠퍼스 산학협력단 | Biomarker composition for predicting Odontogenic Differentiation of Dental Pulp Stem Cell |
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US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
EP1379545A2 (en) | 2001-04-19 | 2004-01-14 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Method for producing stable, regeneratable antibody arrays |
US20030013208A1 (en) | 2001-07-13 | 2003-01-16 | Milagen, Inc. | Information enhanced antibody arrays |
US20060106020A1 (en) | 2004-04-28 | 2006-05-18 | Rodgers James D | Tetracyclic inhibitors of Janus kinases |
AR054416A1 (en) | 2004-12-22 | 2007-06-27 | Incyte Corp | PIRROLO [2,3-B] PIRIDIN-4-IL-AMINAS AND PIRROLO [2,3-B] PIRIMIDIN-4-IL-AMINAS AS INHIBITORS OF THE JANUS KINASES. PHARMACEUTICAL COMPOSITIONS. |
EP1926735A1 (en) | 2005-09-22 | 2008-06-04 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
MY162590A (en) | 2005-12-13 | 2017-06-30 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b] pyridines and pyrrolo[2,3-b] pyrimidines as janus kinase inhibitors |
US8513270B2 (en) | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
EP3495369B1 (en) | 2007-06-13 | 2021-10-27 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
CL2008001709A1 (en) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compounds derived from pyrrolo [2,3-b] pyrimidine, jak kinase modulators; pharmaceutical composition; and use in the treatment of diseases such as cancer, psoriasis, rheumatoid arthritis, among others. |
CA2704599C (en) | 2007-11-16 | 2015-05-12 | Incyte Corporation | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
SI2288610T1 (en) | 2008-03-11 | 2016-11-30 | Incyte Holdings Corporation | Azetidine and cyclobutane derivatives as jak inhibitors |
CL2009001884A1 (en) | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Use of 3-cyclopentyl-3- [4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl) -1h-pyrazol-1-yl) propanonitrile, janus kinase inhibitor, and use of a composition that understands it for the treatment of dry eye. |
JOP20190230A1 (en) | 2009-01-15 | 2017-06-16 | Incyte Corp | Processes for preparing jak inhibitors and related intermediate compounds |
EA025520B1 (en) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
MX2011012262A (en) | 2009-05-22 | 2012-01-25 | Incyte Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors. |
UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
PT2486041E (en) | 2009-10-09 | 2013-11-14 | Incyte Corp | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
US8570829B2 (en) | 2009-12-22 | 2013-10-29 | Pgs Geophysical As | Depth steerable seismic source array |
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SI3354652T1 (en) | 2010-03-10 | 2020-08-31 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
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US20130115232A1 (en) * | 2011-10-03 | 2013-05-09 | Fred Hutchinson Cancer Research Center | Methods for detecting graft-versus-host disease |
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EA030705B1 (en) | 2013-03-06 | 2018-09-28 | Инсайт Холдингс Корпорейшн | Processes and intermediates for making a jak inhibitor |
PE20160126A1 (en) | 2013-05-17 | 2016-02-24 | Incyte Corp | DERIVATIVES OF BIPIRAZOLE AS JAK INHIBITORS |
ES2792549T3 (en) | 2013-08-07 | 2020-11-11 | Incyte Corp | Sustained-release dosage forms for a JAK1 inhibitor |
CN105555313A (en) | 2013-08-20 | 2016-05-04 | 因赛特公司 | Survival benefit in patients with solid tumors with elevated c-reactive protein levels |
CN106456773A (en) | 2014-02-28 | 2017-02-22 | 因赛特公司 | Jak1 inhibitors for the treatment of myelodysplastic syndromes |
AU2015253192B2 (en) | 2014-04-30 | 2019-05-16 | Incyte Holdings Corporation | Processes of preparing a JAK1 inhibitor and new forms thereto |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
WO2016085866A1 (en) | 2014-11-25 | 2016-06-02 | Indiana University Research And Technology Corporation | Biomarkers and assay to detect chronic graft versus host disease |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
PL3746429T3 (en) | 2018-01-30 | 2022-06-20 | Incyte Corporation | Processes for preparing (1-(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
SG11202007805SA (en) | 2018-02-16 | 2020-09-29 | Incyte Corp | Jak1 pathway inhibitors for the treatment of cytokine-related disorders |
US11584961B2 (en) | 2018-03-30 | 2023-02-21 | Incyte Corporation | Biomarkers for inflammatory skin disease |
WO2019191684A1 (en) | 2018-03-30 | 2019-10-03 | Incyte Corporation | Treatment of hidradenitis suppurativa using jak inhibitors |
MX2020010815A (en) * | 2018-04-13 | 2020-12-11 | Incyte Corp | Biomarkers for graft-versus-host disease. |
US11324749B2 (en) | 2018-10-31 | 2022-05-10 | Incyte Corporation | Combination therapy for treatment of hematological diseases |
CN113692278A (en) | 2018-12-19 | 2021-11-23 | 因赛特公司 | JAK1 pathway inhibitors for the treatment of gastrointestinal diseases |
US20210123931A1 (en) | 2019-10-10 | 2021-04-29 | Incyte Corporation | Biomarkers for graft-versus-host disease |
US20210123930A1 (en) | 2019-10-10 | 2021-04-29 | Incyte Corporation | Biomarkers for graft-versus-host disease |
-
2019
- 2019-04-11 MX MX2020010815A patent/MX2020010815A/en unknown
- 2019-04-11 CN CN201980037746.0A patent/CN112567247A/en active Pending
- 2019-04-11 SG SG11202010092XA patent/SG11202010092XA/en unknown
- 2019-04-11 EP EP19720251.8A patent/EP3775923A1/en active Pending
- 2019-04-11 JP JP2020555876A patent/JP7378420B2/en active Active
- 2019-04-11 WO PCT/US2019/026884 patent/WO2019200030A1/en unknown
- 2019-04-11 US US16/381,158 patent/US11372003B2/en active Active
- 2019-04-11 KR KR1020207032759A patent/KR20210018218A/en not_active Application Discontinuation
- 2019-04-11 MA MA052208A patent/MA52208A/en unknown
- 2019-04-11 AU AU2019252259A patent/AU2019252259A1/en active Pending
- 2019-04-11 CA CA3097025A patent/CA3097025A1/en active Pending
- 2019-04-12 TW TW108112848A patent/TW202012935A/en unknown
-
2020
- 2020-10-12 PH PH12020551683A patent/PH12020551683A1/en unknown
- 2020-10-12 IL IL277955A patent/IL277955A/en unknown
-
2022
- 2022-05-20 US US17/749,376 patent/US20230027606A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN112567247A (en) | 2021-03-26 |
US11372003B2 (en) | 2022-06-28 |
MA52208A (en) | 2021-02-17 |
JP7378420B2 (en) | 2023-11-13 |
EP3775923A1 (en) | 2021-02-17 |
PH12020551683A1 (en) | 2021-08-16 |
TW202012935A (en) | 2020-04-01 |
US20190331697A1 (en) | 2019-10-31 |
MX2020010815A (en) | 2020-12-11 |
AU2019252259A1 (en) | 2020-12-03 |
WO2019200030A1 (en) | 2019-10-17 |
US20230027606A1 (en) | 2023-01-26 |
IL277955A (en) | 2020-11-30 |
KR20210018218A (en) | 2021-02-17 |
CA3097025A1 (en) | 2019-10-17 |
JP2021521442A (en) | 2021-08-26 |
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