JO3441B1 - طرق لاصلاح مثبطات انزيم jak والمركبات الوسيطة المتعلقة به - Google Patents

طرق لاصلاح مثبطات انزيم jak والمركبات الوسيطة المتعلقة به

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Publication number
JO3441B1
JO3441B1 JOP/2010/0010A JOP20100010A JO3441B1 JO 3441 B1 JO3441 B1 JO 3441B1 JO P20100010 A JOP20100010 A JO P20100010A JO 3441 B1 JO3441 B1 JO 3441B1
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JO
Jordan
Prior art keywords
processes
intermediate compounds
jak inhibitors
related intermediate
preparing
Prior art date
Application number
JOP/2010/0010A
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English (en)
Inventor
Qiyan Lin
Brian W Metcalf
Haisheng Wang
David Meloni
Jiacheng Zhou
Yongchun Pan
Michael Xia
Mei Li
Tai-Yuen Yue
Pingli Liu
James D Rodgers
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Incyte Corp
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Publication of JO3441B1 publication Critical patent/JO3441B1/ar

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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    • C07F7/02—Silicon compounds
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    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
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    • C07F5/02—Boron compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

يتعلق الاكتشاف الحالي بطرق لتحضير بايريمدينات <span dir="LTR">[2,3-<em>d</em>]</span> بايرولو بايرازوليل مستبدلة الجزيئات غير منطبقة مرآويا خاصة بالصيغة <span dir="LTR">III</span> والمركبات الوسيطة التوليفية الصناعية المتعلقة بها. البايريمدينات <span dir="LTR">[2,3-<em>d</em>]</span> بايرولو بايرازوليل مستبدلة الجزيئات غير المنطبقة مرآويا مفيدة كمثبطات لعائلة مستقبِل كاينيز جانوس لبروتين كاينيز تايروزين لمعالجة الامراض الالتهابية واضطرابات التشعب النخاعي العظمي وغير ذلك من الامراض.
JOP/2010/0010A 2009-01-15 2010-01-14 طرق لاصلاح مثبطات انزيم jak والمركبات الوسيطة المتعلقة به JO3441B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14499109P 2009-01-15 2009-01-15

Publications (1)

Publication Number Publication Date
JO3441B1 true JO3441B1 (ar) 2019-10-20

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ID=42026219

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JOP/2019/0230A JOP20190230A1 (ar) 2009-01-15 2009-01-15 طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
JOP/2019/0231A JOP20190231A1 (ar) 2009-01-15 2009-01-15 طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
JOP/2010/0010A JO3441B1 (ar) 2009-01-15 2010-01-14 طرق لاصلاح مثبطات انزيم jak والمركبات الوسيطة المتعلقة به

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JOP/2019/0230A JOP20190230A1 (ar) 2009-01-15 2009-01-15 طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
JOP/2019/0231A JOP20190231A1 (ar) 2009-01-15 2009-01-15 طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به

Country Status (29)

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US (9) US8410265B2 (ar)
EP (2) EP2398774B1 (ar)
JP (6) JP5650662B2 (ar)
KR (7) KR101824742B1 (ar)
CN (3) CN105669675A (ar)
AR (2) AR082747A1 (ar)
AU (5) AU2010204772B2 (ar)
BR (3) BR122020005540B8 (ar)
CA (2) CA2749483C (ar)
CL (3) CL2011001668A1 (ar)
CO (1) CO6400137A2 (ar)
EA (3) EA020643B1 (ar)
EC (1) ECSP11011268A (ar)
ES (1) ES2641761T3 (ar)
IL (7) IL214061A (ar)
JO (3) JOP20190230A1 (ar)
MA (1) MA33038B1 (ar)
MX (5) MX363976B (ar)
MY (3) MY163540A (ar)
NZ (5) NZ706894A (ar)
PE (4) PE20171102A1 (ar)
PH (1) PH12016502060B1 (ar)
PL (1) PL2398774T3 (ar)
PT (1) PT2398774T (ar)
SG (3) SG10201913261QA (ar)
TN (1) TN2011000329A1 (ar)
TW (7) TWI740775B (ar)
WO (1) WO2010083283A2 (ar)
ZA (1) ZA201104909B (ar)

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