LT2975042T - Naujieji kondensuoti pirimidino dariniai, skirti tirozino kinazės aktyvumo slopinimui - Google Patents
Naujieji kondensuoti pirimidino dariniai, skirti tirozino kinazės aktyvumo slopinimuiInfo
- Publication number
- LT2975042T LT2975042T LTEP15181011.6T LT15181011T LT2975042T LT 2975042 T LT2975042 T LT 2975042T LT 15181011 T LT15181011 T LT 15181011T LT 2975042 T LT2975042 T LT 2975042T
- Authority
- LT
- Lithuania
- Prior art keywords
- inhibition
- tyrosine kinase
- kinase activity
- pyrimidine derivatives
- fused pyrimidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3834—Aromatic acids (P-C aromatic linkage)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20100059686 | 2010-06-23 |
Publications (1)
Publication Number | Publication Date |
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LT2975042T true LT2975042T (lt) | 2019-01-25 |
Family
ID=45371929
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP15181011.6T LT2975042T (lt) | 2010-06-23 | 2011-06-20 | Naujieji kondensuoti pirimidino dariniai, skirti tirozino kinazės aktyvumo slopinimui |
LTEP11798350.2T LT2585470T (lt) | 2010-06-23 | 2011-06-20 | Nauji kondensuoti pirimidino dariniai tirozino kinazės aktyvumo slopinimui |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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LTEP11798350.2T LT2585470T (lt) | 2010-06-23 | 2011-06-20 | Nauji kondensuoti pirimidino dariniai tirozino kinazės aktyvumo slopinimui |
Country Status (31)
Country | Link |
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US (4) | US8957065B2 (lt) |
EP (2) | EP2975042B1 (lt) |
JP (2) | JP5834347B2 (lt) |
KR (2) | KR101587506B1 (lt) |
CN (2) | CN102947316B (lt) |
AR (2) | AR081978A1 (lt) |
AU (1) | AU2011269989B2 (lt) |
BR (2) | BR112012033253A2 (lt) |
CA (1) | CA2803056C (lt) |
CY (1) | CY1118750T1 (lt) |
DK (2) | DK2585470T3 (lt) |
ES (2) | ES2703552T3 (lt) |
HK (1) | HK1211575A1 (lt) |
HR (2) | HRP20170456T1 (lt) |
HU (2) | HUE042165T2 (lt) |
IL (2) | IL223689A (lt) |
LT (2) | LT2975042T (lt) |
MX (2) | MX2012014601A (lt) |
MY (2) | MY162132A (lt) |
NZ (2) | NZ627709A (lt) |
PL (2) | PL2585470T3 (lt) |
PT (2) | PT2975042T (lt) |
RS (2) | RS58265B1 (lt) |
RU (2) | RU2585177C2 (lt) |
SG (1) | SG186378A1 (lt) |
SI (2) | SI2975042T1 (lt) |
TR (1) | TR201821217T4 (lt) |
TW (2) | TWI528962B (lt) |
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