BR112012033253A2 - novos derivados de pirimidina fundidos para inibição da atividade de tirosina quinase - Google Patents
novos derivados de pirimidina fundidos para inibição da atividade de tirosina quinaseInfo
- Publication number
- BR112012033253A2 BR112012033253A2 BR112012033253A BR112012033253A BR112012033253A2 BR 112012033253 A2 BR112012033253 A2 BR 112012033253A2 BR 112012033253 A BR112012033253 A BR 112012033253A BR 112012033253 A BR112012033253 A BR 112012033253A BR 112012033253 A2 BR112012033253 A2 BR 112012033253A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibition
- tyrosine kinase
- kinase activity
- pyrimidine derivatives
- fused pyrimidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
novos derivados de pirimidina fundidos para inibição da atividade de tirosina quinase. a presente invenção refere-se a um novo derivado de pirimidina contendo uma atividade e inibitória para tirosinas quinases, e uma composição farmacêutica para prevenir ou tratar cânceres, tumores, doenças inflamatórias, doenças autoimunes, ou doenças mediadas imunologicamente compreendendo o mesmo como um lingrediente ativo.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR122014012788-0A BR122014012788B1 (pt) | 2010-06-23 | 2011-06-20 | Derivados de pirimidina fundidos, seus usos, e composição farmacêutica para inibição da atividade de tirosina quinase |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20100059686 | 2010-06-23 | ||
PCT/KR2011/004482 WO2011162515A2 (en) | 2010-06-23 | 2011-06-20 | Novel fused pyrimidine derivatives for inhd3ition of tyrosine kinase activity |
Publications (1)
Publication Number | Publication Date |
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BR112012033253A2 true BR112012033253A2 (pt) | 2016-11-22 |
Family
ID=45371929
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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BR122014012788-0A BR122014012788B1 (pt) | 2010-06-23 | 2011-06-20 | Derivados de pirimidina fundidos, seus usos, e composição farmacêutica para inibição da atividade de tirosina quinase |
BR112012033253A BR112012033253A2 (pt) | 2010-06-23 | 2011-06-20 | novos derivados de pirimidina fundidos para inibição da atividade de tirosina quinase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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BR122014012788-0A BR122014012788B1 (pt) | 2010-06-23 | 2011-06-20 | Derivados de pirimidina fundidos, seus usos, e composição farmacêutica para inibição da atividade de tirosina quinase |
Country Status (31)
Country | Link |
---|---|
US (4) | US8957065B2 (pt) |
EP (2) | EP2975042B1 (pt) |
JP (2) | JP5834347B2 (pt) |
KR (2) | KR101587506B1 (pt) |
CN (2) | CN102947316B (pt) |
AR (2) | AR081978A1 (pt) |
AU (1) | AU2011269989B2 (pt) |
BR (2) | BR122014012788B1 (pt) |
CA (1) | CA2803056C (pt) |
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