ECSP15025093A - Derivados de Oxazolidin-2-ona-Pirimidina - Google Patents

Derivados de Oxazolidin-2-ona-Pirimidina

Info

Publication number
ECSP15025093A
ECSP15025093A ECIEPI201525093A ECPI201525093A ECSP15025093A EC SP15025093 A ECSP15025093 A EC SP15025093A EC IEPI201525093 A ECIEPI201525093 A EC IEPI201525093A EC PI201525093 A ECPI201525093 A EC PI201525093A EC SP15025093 A ECSP15025093 A EC SP15025093A
Authority
EC
Ecuador
Prior art keywords
oxazolidin
pyrimidine derivatives
pi3k
phosphatidylinositol
kinase
Prior art date
Application number
ECIEPI201525093A
Other languages
English (en)
Inventor
Heinrich Rueeger
Julie L Yessin
Robin Alec Fairhurst
Y Distribuidora Emaus E I R L Importadora
Frank Stephan Kalthoff
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP15025093A publication Critical patent/ECSP15025093A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con compuestos de pirimidina oxazolidin-2-ona sustituidos que actúan como inhibidores de la PI3K (fosfatidilinositol-3-quinasa), así como también composiciones farmacéuticas de los mismos, métodos para su fabricación y usos para el tratamiento de condiciones, enfermedades y trastornos dependientes de quinasas PI3K.
ECIEPI201525093A 2012-11-12 2015-06-12 Derivados de Oxazolidin-2-ona-Pirimidina ECSP15025093A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261725113P 2012-11-12 2012-11-12

Publications (1)

Publication Number Publication Date
ECSP15025093A true ECSP15025093A (es) 2019-03-29

Family

ID=49667527

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201525093A ECSP15025093A (es) 2012-11-12 2015-06-12 Derivados de Oxazolidin-2-ona-Pirimidina

Country Status (43)

Country Link
US (3) US9296733B2 (es)
EP (2) EP3199158B1 (es)
JP (1) JP6262245B2 (es)
KR (1) KR102153763B1 (es)
CN (1) CN104718204B (es)
AP (1) AP2015008347A0 (es)
AR (1) AR093408A1 (es)
AU (1) AU2013343022B2 (es)
BR (1) BR112015010136A2 (es)
CA (1) CA2890942C (es)
CL (1) CL2015001202A1 (es)
CO (1) CO7380758A2 (es)
CR (1) CR20150248A (es)
CU (1) CU24365B1 (es)
CY (1) CY1119391T1 (es)
DK (1) DK2922848T5 (es)
EA (2) EA027987B1 (es)
EC (1) ECSP15025093A (es)
ES (1) ES2641820T3 (es)
HK (1) HK1209108A1 (es)
HR (1) HRP20171425T1 (es)
HU (1) HUE034492T2 (es)
IL (1) IL238239A (es)
IN (1) IN2015DN02912A (es)
JO (1) JO3334B1 (es)
LT (1) LT2922848T (es)
MA (1) MA38076A1 (es)
MX (1) MX363436B (es)
MY (1) MY174239A (es)
NZ (1) NZ706591A (es)
PE (1) PE20151006A1 (es)
PH (1) PH12015501053A1 (es)
PL (1) PL2922848T3 (es)
PT (1) PT2922848T (es)
RS (1) RS56336B1 (es)
SG (1) SG11201503447QA (es)
SI (1) SI2922848T1 (es)
TN (1) TN2015000120A1 (es)
TW (1) TWI608005B (es)
UA (1) UA114001C2 (es)
UY (1) UY35128A (es)
WO (1) WO2014072956A1 (es)
ZA (1) ZA201502175B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX342326B (es) 2011-09-27 2016-09-26 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
BR112015023412A8 (pt) 2013-03-14 2018-01-23 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante, sua composição farmacêutica e seu uso.
KR20180081501A (ko) 2015-09-24 2018-07-16 드렉셀유니버시티 진피 장애를 치료하거나 예방하는 신규한 조성물 및 방법
RU2018140001A (ru) 2016-05-18 2020-06-18 Пикур Терапьютикс Аг Лечение повреждений кожи
TW201929861A (zh) 2017-11-06 2019-08-01 瑞士商諾華公司 包含㗁唑啶-2-酮-嘧啶衍生物之調配物
CN116438200A (zh) 2020-09-10 2023-07-14 普雷西里克斯公司 针对fap的抗体片段
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

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