TW200833342A - 2-substituted pyrimidines I in therapy - Google Patents

2-substituted pyrimidines I in therapy

Info

Publication number
TW200833342A
TW200833342A TW096150615A TW96150615A TW200833342A TW 200833342 A TW200833342 A TW 200833342A TW 096150615 A TW096150615 A TW 096150615A TW 96150615 A TW96150615 A TW 96150615A TW 200833342 A TW200833342 A TW 200833342A
Authority
TW
Taiwan
Prior art keywords
therapy
substituted pyrimidines
formula
pyrimidines
substituted
Prior art date
Application number
TW096150615A
Other languages
Chinese (zh)
Inventor
Barbara Nave
Sven Harmsen
Bernd Mueller
Thomas Grote
Frank Schieweck
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of TW200833342A publication Critical patent/TW200833342A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to the use of 2-substituted pyrimidines of the formula I or the pharmaceutically acceptable salts thereof in therapy. In formula I the indices and the substituents are as definedin the claims and the specification.
TW096150615A 2006-12-28 2007-12-27 2-substituted pyrimidines I in therapy TW200833342A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06127316 2006-12-28

Publications (1)

Publication Number Publication Date
TW200833342A true TW200833342A (en) 2008-08-16

Family

ID=39023533

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096150615A TW200833342A (en) 2006-12-28 2007-12-27 2-substituted pyrimidines I in therapy

Country Status (4)

Country Link
AR (1) AR064571A1 (en)
CL (1) CL2007003847A1 (en)
TW (1) TW200833342A (en)
WO (1) WO2008080937A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI547493B (en) * 2011-09-27 2016-09-01 諾華公司 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY34632A (en) 2012-02-24 2013-05-31 Novartis Ag OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
EP2970242B1 (en) * 2013-03-14 2017-09-06 Novartis AG 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
EP2970240B1 (en) 2013-03-14 2018-01-10 Novartis AG 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
WO2014147586A1 (en) * 2013-03-22 2014-09-25 Novartis Ag 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh
CA3047136A1 (en) * 2016-12-19 2018-06-28 Isocure Biosciences Inc. Inhibitors of mutant isocitrate dehydrogenases and compositions and methods thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100347267B1 (en) * 1999-07-06 2002-11-16 주식회사 경인제약 Functional beverage containing submerged culture broth of Paecilomyces sp. and process for preparation thereof
BRPI0510486A (en) * 2004-05-19 2007-11-20 Basf Ag compound, process for preparing same, pesticidal agent, and process for combating phytopathogenic fungi

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI547493B (en) * 2011-09-27 2016-09-01 諾華公司 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh

Also Published As

Publication number Publication date
WO2008080937A1 (en) 2008-07-10
CL2007003847A1 (en) 2008-04-18
AR064571A1 (en) 2009-04-08

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