CY1119391T1 - Παραγωγα οξαζολιδιν-2- ονη- πυριμιδινης - Google Patents

Παραγωγα οξαζολιδιν-2- ονη- πυριμιδινης

Info

Publication number
CY1119391T1
CY1119391T1 CY20171101014T CY171101014T CY1119391T1 CY 1119391 T1 CY1119391 T1 CY 1119391T1 CY 20171101014 T CY20171101014 T CY 20171101014T CY 171101014 T CY171101014 T CY 171101014T CY 1119391 T1 CY1119391 T1 CY 1119391T1
Authority
CY
Cyprus
Prior art keywords
oxazolidin
ony
diseases
pyrimidine products
pi3k
Prior art date
Application number
CY20171101014T
Other languages
English (en)
Inventor
Robin Alec Fairhurst
Pascal Furet
Frank Stephan Dr Kalthoff
Andreas Lerchner
Heinrich Rueeger
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1119391T1 publication Critical patent/CY1119391T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται στις οξαζολιδιν-2-ονη υποκατεστημένες ενώσεις πυριμιδίνης που δρουν ως ΡΙ3Κ (κινάση 3 της φωσφατιδυλοϊνοσιτολης) αναστολείς, καθώς επίσης και στις φαρμακευτικές συνθέσεις αυτών, στις μεθόδους παρασκευής τους και στη χρήση αυτών στην αντιμετώπιση παθήσεων, νοσημάτων και διαταραχών που εξαρτώνται από την ΡΙ3Κ.
CY20171101014T 2012-11-12 2017-09-27 Παραγωγα οξαζολιδιν-2- ονη- πυριμιδινης CY1119391T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261725113P 2012-11-12 2012-11-12
PCT/IB2013/060052 WO2014072956A1 (en) 2012-11-12 2013-11-11 Oxazolidin-2-one-pyrimidine derivatives

Publications (1)

Publication Number Publication Date
CY1119391T1 true CY1119391T1 (el) 2018-02-14

Family

ID=49667527

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171101014T CY1119391T1 (el) 2012-11-12 2017-09-27 Παραγωγα οξαζολιδιν-2- ονη- πυριμιδινης

Country Status (43)

Country Link
US (3) US9296733B2 (el)
EP (2) EP3199158B1 (el)
JP (1) JP6262245B2 (el)
KR (1) KR102153763B1 (el)
CN (1) CN104718204B (el)
AP (1) AP2015008347A0 (el)
AR (1) AR093408A1 (el)
AU (1) AU2013343022B2 (el)
BR (1) BR112015010136A2 (el)
CA (1) CA2890942C (el)
CL (1) CL2015001202A1 (el)
CO (1) CO7380758A2 (el)
CR (1) CR20150248A (el)
CU (1) CU24365B1 (el)
CY (1) CY1119391T1 (el)
DK (1) DK2922848T5 (el)
EA (2) EA029714B1 (el)
EC (1) ECSP15025093A (el)
ES (1) ES2641820T3 (el)
HK (1) HK1209108A1 (el)
HR (1) HRP20171425T1 (el)
HU (1) HUE034492T2 (el)
IL (1) IL238239A (el)
IN (1) IN2015DN02912A (el)
JO (1) JO3334B1 (el)
LT (1) LT2922848T (el)
MA (1) MA38076A1 (el)
MX (1) MX363436B (el)
MY (1) MY174239A (el)
NZ (1) NZ706591A (el)
PE (1) PE20151006A1 (el)
PH (1) PH12015501053B1 (el)
PL (1) PL2922848T3 (el)
PT (1) PT2922848T (el)
RS (1) RS56336B1 (el)
SG (1) SG11201503447QA (el)
SI (1) SI2922848T1 (el)
TN (1) TN2015000120A1 (el)
TW (1) TWI608005B (el)
UA (1) UA114001C2 (el)
UY (1) UY35128A (el)
WO (1) WO2014072956A1 (el)
ZA (1) ZA201502175B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140069235A (ko) 2011-09-27 2014-06-09 노파르티스 아게 돌연변이체 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
CN105263929B (zh) 2013-03-14 2018-08-28 诺华股份有限公司 作为突变idh抑制剂的3-嘧啶-4-基-噁唑烷-2-酮化合物
WO2017053222A1 (en) 2015-09-24 2017-03-30 Drexel University Novel compositions and methods for treating or preventing dermal disorders
BR112018073549A8 (pt) 2016-05-18 2023-01-10 Univ Pennsylvania Uso de inibidores seletivos e específicos de mtor e/ou de inibidores duplos de pi3k/mtor, e composição farmacêutica
TW201929861A (zh) 2017-11-06 2019-08-01 瑞士商諾華公司 包含㗁唑啶-2-酮-嘧啶衍生物之調配物
EP4211171A2 (en) 2020-09-10 2023-07-19 Precirix N.V. Antibody fragment against fap
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

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