CY1124316T1 - Κρυσταλλικο τοσυλικο αλας ενος ρι3κ δελτα εκλεκτικου αναστολεα για χρηση σε φαρμακευτικα σκευασματα - Google Patents
Κρυσταλλικο τοσυλικο αλας ενος ρι3κ δελτα εκλεκτικου αναστολεα για χρηση σε φαρμακευτικα σκευασματαInfo
- Publication number
- CY1124316T1 CY1124316T1 CY20211100652T CY211100652T CY1124316T1 CY 1124316 T1 CY1124316 T1 CY 1124316T1 CY 20211100652 T CY20211100652 T CY 20211100652T CY 211100652 T CY211100652 T CY 211100652T CY 1124316 T1 CY1124316 T1 CY 1124316T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical preparations
- pi3k delta
- selective inhibitor
- tosylate salt
- crystalline tosylate
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μορφές στερεάς κατάστασης ενός άλατος p-τολουολοσουλφονικού οξέος (PTSA) του εκλεκτικού ΡΙ3Κ δέλτα αναστολέα (S)-2-(1-(4-αμινο-3-(3-φθορο-4-ισοπροποξυφαινυλ)-1Η-πυραζολο[3,4-d]πυριμιδιν-1-υλ)αιθυλ)-3-(3-φθορο-φαινυλ)-4Η-χρωμεν-4-όνη (TGR-1202). Η παρούσα εφεύρεση αφορά επίσης μεθόδους παρασκευής αυτών, φαρμακευτικές συνθέσεις που περιέχουν αυτές και μεθόδους θεραπείας μιας νόσου ή διαταραχής που διαμεσολαβείται από ΡΙ3Κ κινάση, όπως ο καρκίνος, δια της χορήγησης αυτών.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2597CH2014 | 2014-05-27 | ||
IN2596CH2014 | 2014-05-27 | ||
PCT/IB2015/053940 WO2015181728A1 (en) | 2014-05-27 | 2015-05-26 | Improved forms of a pi3k delta selective inhibitor for use in pharmaceutical formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124316T1 true CY1124316T1 (el) | 2022-07-22 |
Family
ID=53499042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100652T CY1124316T1 (el) | 2014-05-27 | 2021-07-21 | Κρυσταλλικο τοσυλικο αλας ενος ρι3κ δελτα εκλεκτικου αναστολεα για χρηση σε φαρμακευτικα σκευασματα |
Country Status (21)
Country | Link |
---|---|
US (4) | US9969740B2 (el) |
EP (2) | EP3971188A1 (el) |
JP (3) | JP6987501B2 (el) |
KR (1) | KR20170007480A (el) |
CN (2) | CN111635406A (el) |
AU (1) | AU2015265542B2 (el) |
BR (1) | BR112016027674A2 (el) |
CA (1) | CA2949932C (el) |
CY (1) | CY1124316T1 (el) |
DK (1) | DK3149000T3 (el) |
EA (1) | EA032506B1 (el) |
ES (1) | ES2880999T3 (el) |
HR (1) | HRP20211151T1 (el) |
HU (1) | HUE054916T2 (el) |
IL (1) | IL249058B2 (el) |
LT (1) | LT3149000T (el) |
PL (1) | PL3149000T3 (el) |
PT (1) | PT3149000T (el) |
RS (1) | RS62136B1 (el) |
SI (1) | SI3149000T1 (el) |
WO (1) | WO2015181728A1 (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3149000T3 (da) * | 2014-05-27 | 2021-08-30 | Rhizen Pharmaceuticals S A | Krystallinsk tosylatsalt af en pi3k-delta-selektiv inhibitor til anvendelse i farmaceutiske formuleringer |
BR112018074238A2 (pt) | 2016-05-27 | 2019-04-16 | Tg Therapeutics, Inc. | combinação de anticorpo anti-cd20, inibidor de p13 quinase-delta seletivo e inibidor de btk para tratar desordens proliferativas de células b |
AU2017322501A1 (en) | 2016-09-09 | 2019-03-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combination of an anti-CD20 antibody, PI3 kinase-delta inhibitor, and anti-PD-1 or anti-PD-L1 antibody for treating hematological cancers |
KR20220035169A (ko) * | 2019-07-15 | 2022-03-21 | 존슨 맛쎄이 퍼블릭 리미티드 컴파니 | 비정질 움브랄리십 모노토실레이트 |
WO2022104150A1 (en) | 2020-11-12 | 2022-05-19 | Tg Therapeutics, Inc. | Triple combination to treat b-cell malignancies |
US11807689B1 (en) | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
US11884740B1 (en) | 2022-06-01 | 2024-01-30 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
US11814439B1 (en) | 2022-06-01 | 2023-11-14 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
US11965032B1 (en) | 2022-06-01 | 2024-04-23 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02010618A (es) * | 2000-04-25 | 2004-05-05 | Icos Corp | Inhibidores de fosfatidilinositol 3-quinasa delta. |
BRPI0316779B1 (pt) | 2002-12-16 | 2020-04-28 | Genentech Inc | anticorpo humanizado que liga cd20 humano, composição, artigo manufaturado, método de indução da apoptose, método de tratamento de câncer cd20 positivo, métodos de tratamento de doenças autoimunes, ácidos nucléicos isolados, vetores de expressão, células hospedeiras, método para a produção de um anticorpo 2h7 humanizado, polipeptídeo isolado, formulação líquida, método de tratamento de artrite reumatóide (ra) e anticorpos de ligação de cd20 humanizados |
US20050043239A1 (en) | 2003-08-14 | 2005-02-24 | Jason Douangpanya | Methods of inhibiting immune responses stimulated by an endogenous factor |
WO2010057048A1 (en) | 2008-11-13 | 2010-05-20 | Calistoga Pharmaceuticals Inc. | Therapies for hematologic malignancies |
CN102439012A (zh) | 2009-03-24 | 2012-05-02 | 吉里德卡利斯托加公司 | 2-嘌呤基-3-甲苯基-喹唑啉酮衍生物的阻转异构体和使用方法 |
KR20120005523A (ko) | 2009-04-20 | 2012-01-16 | 길리아드 칼리스토가 엘엘씨 | 고형 종양의 치료 방법 |
SI2870157T1 (en) * | 2012-07-04 | 2018-02-28 | Rhizen Pharmaceuticals S.A. | SELECTIVE PI3K-DELTA INHIBITORS |
DK3149000T3 (da) * | 2014-05-27 | 2021-08-30 | Rhizen Pharmaceuticals S A | Krystallinsk tosylatsalt af en pi3k-delta-selektiv inhibitor til anvendelse i farmaceutiske formuleringer |
-
2015
- 2015-05-26 DK DK15733532.4T patent/DK3149000T3/da active
- 2015-05-26 CA CA2949932A patent/CA2949932C/en active Active
- 2015-05-26 EP EP21182208.5A patent/EP3971188A1/en not_active Withdrawn
- 2015-05-26 ES ES15733532T patent/ES2880999T3/es active Active
- 2015-05-26 WO PCT/IB2015/053940 patent/WO2015181728A1/en active Application Filing
- 2015-05-26 RS RS20210920A patent/RS62136B1/sr unknown
- 2015-05-26 US US15/313,454 patent/US9969740B2/en active Active
- 2015-05-26 EA EA201692255A patent/EA032506B1/ru unknown
- 2015-05-26 BR BR112016027674A patent/BR112016027674A2/pt not_active Application Discontinuation
- 2015-05-26 SI SI201531656T patent/SI3149000T1/sl unknown
- 2015-05-26 KR KR1020167036318A patent/KR20170007480A/ko not_active Application Discontinuation
- 2015-05-26 PL PL15733532T patent/PL3149000T3/pl unknown
- 2015-05-26 EP EP15733532.4A patent/EP3149000B1/en active Active
- 2015-05-26 CN CN202010471226.5A patent/CN111635406A/zh active Pending
- 2015-05-26 PT PT157335324T patent/PT3149000T/pt unknown
- 2015-05-26 LT LTEPPCT/IB2015/053940T patent/LT3149000T/lt unknown
- 2015-05-26 AU AU2015265542A patent/AU2015265542B2/en active Active
- 2015-05-26 CN CN201580034288.7A patent/CN106661030B/zh active Active
- 2015-05-26 JP JP2016569636A patent/JP6987501B2/ja active Active
- 2015-05-26 HU HUE15733532A patent/HUE054916T2/hu unknown
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2016
- 2016-11-20 IL IL249058A patent/IL249058B2/en unknown
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2018
- 2018-04-11 US US15/950,606 patent/US10414773B2/en active Active
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2019
- 2019-08-30 US US16/557,091 patent/US10947244B2/en active Active
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2020
- 2020-05-20 JP JP2020088147A patent/JP2020122022A/ja active Pending
- 2020-12-23 US US17/247,806 patent/US20210269446A1/en not_active Abandoned
-
2021
- 2021-07-19 HR HRP20211151TT patent/HRP20211151T1/hr unknown
- 2021-07-21 CY CY20211100652T patent/CY1124316T1/el unknown
-
2022
- 2022-04-05 JP JP2022062937A patent/JP2022082680A/ja active Pending
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