|
GB581334A
(en)
|
1943-09-29 |
1946-10-09 |
Francis Henry Swinden Curd |
New pyrimidine compounds
|
|
JPS4921149B1
(pt)
|
1970-12-28 |
1974-05-30 |
|
|
|
JPS4921148B1
(pt)
|
1970-12-28 |
1974-05-30 |
|
|
|
DE2341925A1
(de)
|
1973-08-20 |
1975-03-06 |
Thomae Gmbh Dr K |
Neue pyrimidinderivate und verfahren zu ihrer herstellung
|
|
AT340933B
(de)
|
1973-08-20 |
1978-01-10 |
Thomae Gmbh Dr K |
Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze
|
|
US4994386A
(en)
|
1987-07-13 |
1991-02-19 |
Pharmacia Diagnostics, Inc. |
Production of HBLV virus in the HSB-2 cell line
|
|
US4929726A
(en)
|
1988-02-09 |
1990-05-29 |
Georgia State University Foundation, Inc. |
Novel diazines and their method of preparation
|
|
EP0330263A1
(en)
|
1988-02-25 |
1989-08-30 |
Merck & Co. Inc. |
Piperazinylalkylpyrimidines as hypoglycemic agents
|
|
GB9012311D0
(en)
|
1990-06-01 |
1990-07-18 |
Wellcome Found |
Pharmacologically active cns compounds
|
|
WO1992000970A1
(fr)
|
1990-07-03 |
1992-01-23 |
Mitsui Petrochemical Industries, Limited |
Compose de pyrimidine et sel pharmaceutiquement acceptable de ce compose
|
|
KR100275300B1
(ko)
|
1995-04-13 |
2000-12-15 |
고바야시 유키오 |
신규 4,6-디아릴피리미딘 유도체 및 그 염(novel 4,6-diarylpyrimidine derivatives and salts thereof)
|
|
JP3734907B2
(ja)
|
1996-12-19 |
2006-01-11 |
富士写真フイルム株式会社 |
現像処理方法
|
|
DK1020462T3
(da)
|
1997-07-24 |
2004-04-26 |
Zenyaku Kogyo Kk |
Heterocykliske forbindelser og antitumormiddel indeholdende disse som aktiv ingrediens
|
|
JPH11158073A
(ja)
|
1997-09-26 |
1999-06-15 |
Takeda Chem Ind Ltd |
アデノシンａ３拮抗剤
|
|
US6440965B1
(en)
|
1997-10-15 |
2002-08-27 |
Krenitsky Pharmaceuticals, Inc. |
Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
|
|
US6150362A
(en)
|
1997-12-12 |
2000-11-21 |
Henkin; Jack |
Triazine angiogenesis inhibitors
|
|
DE69906397T2
(de)
|
1998-01-16 |
2004-02-19 |
F. Hoffmann-La Roche Ag |
Benzosulfonderivate
|
|
US6489344B1
(en)
|
1998-06-19 |
2002-12-03 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
US7045519B2
(en)
|
1998-06-19 |
2006-05-16 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
JP2002535318A
(ja)
|
1999-01-22 |
2002-10-22 |
アムジエン・インコーポレーテツド |
キナーゼ阻害薬
|
|
US6495558B1
(en)
|
1999-01-22 |
2002-12-17 |
Amgen Inc. |
Kinase inhibitors
|
|
JP2003503354A
(ja)
|
1999-06-30 |
2003-01-28 |
メルク エンド カムパニー インコーポレーテッド |
Ｓｒｃキナーゼ阻害剤化合物
|
|
ATE253915T1
(de)
|
1999-06-30 |
2003-11-15 |
Merck & Co Inc |
Src-kinase hemmende verbindungen
|
|
AU6605200A
(en)
|
1999-06-30 |
2001-01-31 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
|
WO2001005783A1
(en)
|
1999-07-15 |
2001-01-25 |
Pharmacopeia, Inc. |
Bradykinin b1 receptor antagonists
|
|
JP2001089452A
(ja)
|
1999-09-22 |
2001-04-03 |
Sankyo Co Ltd |
ピリミジン誘導体
|
|
CN1429222A
(zh)
|
2000-02-17 |
2003-07-09 |
安姆根有限公司 |
激酶抑制剂
|
|
CN100355751C
(zh)
|
2000-03-29 |
2007-12-19 |
西克拉塞尔有限公司 |
2－取代的4－杂芳基－嘧啶、其组合物及其用途
|
|
AU5261001A
(en)
|
2000-04-27 |
2001-11-12 |
Imperial Cancer Research Technology Ltd |
Condensed heteroaryl derivatives
|
|
AU4114201A
(en)
|
2000-04-28 |
2001-11-12 |
Tanabe Seiyaku Co |
Cyclic compounds
|
|
WO2002000647A1
(en)
|
2000-06-23 |
2002-01-03 |
Bristol-Myers Squibb Pharma Company |
Heteroaryl-phenyl substituted factor xa inhibitors
|
|
AU9502601A
(en)
|
2000-09-06 |
2002-03-22 |
Chiron Corp |
Inhibitors of glycogen synthase kinase 3
|
|
CA2422367C
(en)
|
2000-09-15 |
2010-05-18 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
SE0004053D0
(sv)
|
2000-11-06 |
2000-11-06 |
Astrazeneca Ab |
N-type calcium channel antagonists for the treatment of pain
|
|
KR100947185B1
(ko)
|
2000-12-21 |
2010-03-15 |
버텍스 파마슈티칼스 인코포레이티드 |
단백질 키나제 억제제로서 유용한 피라졸 화합물 및 이를 포함하는 조성물
|
|
WO2002062766A2
(en)
|
2001-02-07 |
2002-08-15 |
Millennium Pharmaceuticals, Inc. |
Melanocortin-4 receptor binding compounds and methods of use thereof
|
|
AU2002258400A1
(en)
|
2001-02-16 |
2002-08-28 |
Tularik Inc. |
Methods of using pyrimidine-based antiviral agents
|
|
EP1395561A1
(en)
|
2001-05-25 |
2004-03-10 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Carbamate and oxamide compounds as inhibitors of cytokine production
|
|
CA2450934A1
(en)
|
2001-06-19 |
2002-12-27 |
Marco Dodier |
Pyrimidine inhibitors of phosphodiesterase (pde) 7
|
|
US6603000B2
(en)
|
2001-07-11 |
2003-08-05 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Synthesis for heteroarylamine compounds
|
|
WO2003030909A1
(en)
|
2001-09-25 |
2003-04-17 |
Bayer Pharmaceuticals Corporation |
2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
|
|
WO2004078163A2
(en)
|
2003-02-28 |
2004-09-16 |
Transform Pharmaceuticals, Inc. |
Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
|
|
ATE466580T1
(de)
|
2002-03-15 |
2010-05-15 |
Vertex Pharma |
Azolylaminoazine als proteinkinasehemmer
|
|
DE60314603T2
(de)
|
2002-03-15 |
2008-02-28 |
Vertex Pharmaceuticals Inc., Cambridge |
Zusammensetzungen brauchbar als protein-kinase-inhibitoren
|
|
EP1485380B1
(en)
|
2002-03-15 |
2010-05-19 |
Vertex Pharmaceuticals Incorporated |
Azolylaminoazines as inhibitors of protein kinases
|
|
EP1485381B8
(en)
|
2002-03-15 |
2010-05-12 |
Vertex Pharmaceuticals Incorporated |
Azolylaminoazine as inhibitors of protein kinases
|
|
WO2004000820A2
(en)
|
2002-06-21 |
2003-12-31 |
Cellular Genomics, Inc. |
Certain aromatic monocycles as kinase modulators
|
|
EP1546115A4
(en)
|
2002-09-27 |
2010-08-04 |
Merck Sharp & Dohme |
SUBSTITUTED PYRIMIDINES
|
|
JP2006515274A
(ja)
|
2002-10-08 |
2006-05-25 |
マサチューセッツ・インスティテュート・オブ・テクノロジー |
コレステロール輸送の調節のための化合物
|
|
US7223870B2
(en)
|
2002-11-01 |
2007-05-29 |
Pfizer Inc. |
Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
|
|
CA2507100C
(en)
|
2002-11-21 |
2012-10-09 |
Chiron Corporation |
2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer
|
|
CA2519677A1
(en)
|
2003-03-24 |
2004-10-07 |
Merck & Co., Inc. |
Biaryl substituted 6-membered heterocycles as sodium channel blockers
|
|
US20050014753A1
(en)
|
2003-04-04 |
2005-01-20 |
Irm Llc |
Novel compounds and compositions as protein kinase inhibitors
|
|
US7763627B2
(en)
|
2003-04-09 |
2010-07-27 |
Exelixis, Inc. |
Tie-2 modulators and methods of use
|
|
JP2007523875A
(ja)
|
2003-07-15 |
2007-08-23 |
ニューロジェン・コーポレーション |
バニロイド受容体リガンドとしての置換ピリミジン−４−イルアミン類縁体
|
|
AU2004257289A1
(en)
|
2003-07-16 |
2005-01-27 |
Neurogen Corporation |
Biaryl piperazinyl-pyridine analogues
|
|
AR045944A1
(es)
*
|
2003-09-24 |
2005-11-16 |
Novartis Ag |
Derivados de isoquinolina 1.4-disustituidas
|
|
WO2005099711A1
(en)
|
2004-04-13 |
2005-10-27 |
Icagen, Inc. |
Polycyclic pyrimidines as potassium ion channel modulators
|
|
GB0415365D0
(en)
|
2004-07-09 |
2004-08-11 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
GB0415364D0
(en)
|
2004-07-09 |
2004-08-11 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
MY145822A
(en)
|
2004-08-13 |
2012-04-30 |
Neurogen Corp |
Substituted biaryl piperazinyl-pyridine analogues
|
|
MX2007006230A
(es)
*
|
2004-11-30 |
2007-07-25 |
Amgen Inc |
Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer.
|
|
AU2005317176A1
(en)
|
2004-12-13 |
2006-06-22 |
Neurogen Corporation |
Piperazinyl-pyridine analogues
|
|
CN101080401A
(zh)
|
2004-12-13 |
2007-11-28 |
神经能质公司 |
经取代的二芳基类似物
|
|
EP1836169B9
(en)
|
2004-12-28 |
2012-07-04 |
Kinex Pharmaceuticals, LLC |
Compositions and methods of treating cell proliferation disorders
|
|
CA2595205A1
(en)
|
2005-01-19 |
2006-07-27 |
Neurogen Corporation |
Heteroaryl substituted piperazinyl-pyridine analogues
|
|
CA2599320A1
(en)
|
2005-02-25 |
2006-08-31 |
Kudos Pharmaceuticals Limited |
Hydrazinomethyl, hydr zonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents
|
|
WO2006113704A2
(en)
|
2005-04-18 |
2006-10-26 |
Neurogen Corporation |
Subtituted heteroaryl cb1 antagonists
|
|
GB2431156A
(en)
|
2005-10-11 |
2007-04-18 |
Piramed Ltd |
1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase
|
|
KR20080083188A
(ko)
|
2006-01-11 |
2008-09-16 |
아스트라제네카 아베 |
모르폴리노 피리미딘 유도체 및 요법에서의 그 유도체의용도
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
WO2007120897A2
(en)
*
|
2006-04-13 |
2007-10-25 |
The Trustees Of Columbia University In The City Of New York |
Compositions and intraluminal devices for inhibiting vascular stenosis
|
|
CL2007003847A1
(es)
|
2006-12-28 |
2008-04-18 |
Basf Ag |
Compuestos derivados de pirimidinas 2,4,5 tri-sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento del cancer.
|
|
US8173647B2
(en)
|
2007-02-06 |
2012-05-08 |
Gordana Atallah |
PI 3-kinase inhibitors and methods of their use
|
|
US7957951B2
(en)
|
2007-03-16 |
2011-06-07 |
Robert Bosch Gmbh |
Address translation system for use in a simulation environment
|
|
AU2008273889B2
(en)
|
2007-07-09 |
2012-03-08 |
Astrazeneca Ab |
Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
|
|
WO2009066084A1
(en)
|
2007-11-21 |
2009-05-28 |
F. Hoffmann-La Roche Ag |
2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
|
|
WO2009109605A1
(en)
|
2008-03-05 |
2009-09-11 |
Novartis Ag |
Use of pyrimidine derivatives for the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members
|
|
AU2009228797B2
(en)
|
2008-03-26 |
2012-07-19 |
Novartis Ag |
5imidazoquinolines and pyrimidine derivatives as potent modulators of VEGF-driven angiogenic processes
|
|
EP2276750A2
(en)
|
2008-03-27 |
2011-01-26 |
Auckland Uniservices Limited |
Substituted pyrimidines and triazines and their use in cancer therapy
|
|
US8575338B2
(en)
|
2008-04-09 |
2013-11-05 |
Mitsubishi Tanabe Pharma Corporation |
Pyrimidine, pyridine and triazine derivatives as maxi-K channel openers
|
|
GB0815369D0
(en)
|
2008-08-22 |
2008-10-01 |
Summit Corp Plc |
Compounds for treatment of duchenne muscular dystrophy
|
|
CA2736361C
(en)
|
2008-10-31 |
2017-10-10 |
Novartis Ag |
Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
WO2010068863A2
(en)
|
2008-12-12 |
2010-06-17 |
Cystic Fibrosis Foundation Therapeutics, Inc. |
Pyrimidine compounds and methods of making and using same
|
|
JP5747440B2
(ja)
|
2009-02-06 |
2015-07-15 |
住友化学株式会社 |
ヒドラジド化合物及びその有害生物防除用途
|
|
EP2394999B1
(en)
|
2009-02-06 |
2014-01-29 |
Nippon Shinyaku Co., Ltd. |
Aminopyrazine derivative and medicine
|
|
WO2010105243A1
(en)
|
2009-03-13 |
2010-09-16 |
Agios Pharmaceuticals, Inc. |
Methods and compositions for cell-proliferation-related disorders
|
|
WO2010120994A2
(en)
|
2009-04-17 |
2010-10-21 |
Wyeth Llc |
Ureidoaryl-and carbamoylaryl-morpholino- pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis
|
|
PL2432767T3
(pl)
|
2009-05-19 |
2013-11-29 |
Dow Agrosciences Llc |
Związki i sposoby zwalczania grzybów
|
|
TW201105662A
(en)
|
2009-07-07 |
2011-02-16 |
Pathway Therapeutics Ltd |
Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
|
|
WO2011017296A1
(en)
|
2009-08-04 |
2011-02-10 |
Schering Corporation |
4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
|
|
AR077999A1
(es)
|
2009-09-02 |
2011-10-05 |
Vifor Int Ag |
Antagonistas de pirimidin y triazin-hepcidina
|
|
SG179085A1
(en)
|
2009-09-09 |
2012-04-27 |
Avila Therapeutics Inc |
Pi3 kinase inhibitors and uses thereof
|
|
WO2011072174A1
(en)
|
2009-12-09 |
2011-06-16 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compounds for use in the treatment of cancer characterized as having an idh mutation
|
|
GB201004200D0
(en)
|
2010-03-15 |
2010-04-28 |
Univ Basel |
Spirocyclic compounds and their use as therapeutic agents and diagnostic probes
|
|
EP2560488B1
(en)
|
2010-04-23 |
2015-10-28 |
Cytokinetics, Inc. |
Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
|
|
AR081626A1
(es)
|
2010-04-23 |
2012-10-10 |
Cytokinetics Inc |
Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
|
|
AR081331A1
(es)
|
2010-04-23 |
2012-08-08 |
Cytokinetics Inc |
Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
|
|
US20130109643A1
(en)
|
2010-05-10 |
2013-05-02 |
The Johns Hopkins University |
Metabolic inhibitor against tumors having an idh mutation
|
|
EP2593425B1
(en)
|
2010-07-16 |
2018-10-17 |
Agios Pharmaceuticals, Inc. |
Therapeutically active compositions and their method of use
|
|
WO2012044727A2
(en)
|
2010-10-01 |
2012-04-05 |
Novartis Ag |
Manufacturing process for pyrimidine derivatives
|
|
MX337179B
(es)
|
2010-10-18 |
2016-02-15 |
Cerenis Therapeutics Holding Sa |
Compuestos, composiciones y metodos utiles para la movilizacion de colesterol.
|
|
GB201106829D0
(en)
|
2011-04-21 |
2011-06-01 |
Proximagen Ltd |
Heterocyclic compounds
|
|
JP2014505107A
(ja)
|
2011-02-11 |
2014-02-27 |
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド |
過誤腫性腫瘍細胞を阻害する方法
|
|
CN102827073A
(zh)
|
2011-06-17 |
2012-12-19 |
安吉奥斯医药品有限公司 |
治疗活性组合物和它们的使用方法
|
|
CN103764130A
(zh)
|
2011-09-01 |
2014-04-30 |
诺华股份有限公司 |
用于治疗骨癌或者预防原发性癌细胞转移性播散入骨中的pi3k抑制剂
|
|
KR20140069235A
(ko)
|
2011-09-27 |
2014-06-09 |
노파르티스 아게 |
돌연변이체 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온
|
|
WO2013052395A1
(en)
|
2011-10-06 |
2013-04-11 |
Merck Sharp & Dohme Corp. |
1,3-substituted azetidine pde10 inhibitors
|
|
UY34632A
(es)
|
2012-02-24 |
2013-05-31 |
Novartis Ag |
Compuestos de oxazolidin- 2- ona y usos de los mismos
|
|
RU2630975C2
(ru)
*
|
2012-05-16 |
2017-09-15 |
Новартис Аг |
Режим дозирования pi-3 киназы
|
|
RU2014154009A
(ru)
|
2012-06-06 |
2016-08-10 |
Новартис Аг |
Комбинация ингибитора 17-альфа-гидроксилазы (с17,20-лиазы) и специфического ингибитора pi-3k для лечения онкологического заболевания
|
|
RU2705095C2
(ru)
|
2012-08-16 |
2019-11-05 |
Новартис Аг |
Комбинация ингибитора pik3 и ингибитора с-мет
|
|
RU2646760C2
(ru)
|
2012-10-23 |
2018-03-07 |
Новартис Аг |
Усовершенствованный способ получения 5-(2,6-ди-4-морфолинил-4-пиримидинил)-4-трифторметилпиридин-2-амина
|
|
US9296733B2
(en)
|
2012-11-12 |
2016-03-29 |
Novartis Ag |
Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
|
|
EP2970242B1
(en)
|
2013-03-14 |
2017-09-06 |
Novartis AG |
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
|
|
MX355945B
(es)
|
2013-03-14 |
2018-05-07 |
Novartis Ag |
3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
|
|
CN103483345B
(zh)
|
2013-09-25 |
2016-07-06 |
中山大学 |
Pi3k激酶抑制剂、包含其的药物组合物及其应用
|
|
CN103694218B
(zh)
|
2013-12-05 |
2016-04-27 |
中山大学 |
嘧啶化合物、pi3k抑制剂、包含pi3k抑制剂的药物组合物及应用
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