MX360703B - Proceso mejorado para la elaboración de 5-(2, 6-di-4-morfolinil-4-pirimidinil)-4-trifluoro-metil-piridin-2-amin a. - Google Patents

Proceso mejorado para la elaboración de 5-(2, 6-di-4-morfolinil-4-pirimidinil)-4-trifluoro-metil-piridin-2-amin a.

Info

Publication number
MX360703B
MX360703B MX2015005188A MX2015005188A MX360703B MX 360703 B MX360703 B MX 360703B MX 2015005188 A MX2015005188 A MX 2015005188A MX 2015005188 A MX2015005188 A MX 2015005188A MX 360703 B MX360703 B MX 360703B
Authority
MX
Mexico
Prior art keywords
trifluoromethylpyridin
morpholinyl
amine
manufacturing
improved process
Prior art date
Application number
MX2015005188A
Other languages
English (en)
Other versions
MX2015005188A (es
Inventor
Flubacher Dietmar
Acemoglu Murat
Stettler Hans
Bieri Nicole
Michel Pascal
Mose Rasmus
Caterina Testa Maria
Brozio Jörg
Schaefer Frank
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2015005188A publication Critical patent/MX2015005188A/es
Publication of MX360703B publication Critical patent/MX360703B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención describe procesos mejorados para la elaboración de un compuesto, la 5-(2,6-di-4-morfolinil-4-pirimidinil)-4-trifluoro - metil-piridin-2-amina, su sal de monoclorhidrato, e intermediarios de la misma.
MX2015005188A 2012-10-23 2013-10-21 Proceso mejorado para la elaboración de 5-(2, 6-di-4-morfolinil-4-pirimidinil)-4-trifluoro-metil-piridin-2-amin a. MX360703B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261717237P 2012-10-23 2012-10-23
US201361842101P 2013-07-02 2013-07-02
PCT/EP2013/071996 WO2014064058A1 (en) 2012-10-23 2013-10-21 Improved process for manufacturing 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine

Publications (2)

Publication Number Publication Date
MX2015005188A MX2015005188A (es) 2015-09-07
MX360703B true MX360703B (es) 2018-11-14

Family

ID=49448162

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005188A MX360703B (es) 2012-10-23 2013-10-21 Proceso mejorado para la elaboración de 5-(2, 6-di-4-morfolinil-4-pirimidinil)-4-trifluoro-metil-piridin-2-amin a.

Country Status (15)

Country Link
US (1) US9637468B2 (es)
EP (1) EP2912030B1 (es)
JP (1) JP6267213B2 (es)
KR (1) KR102128127B1 (es)
CN (1) CN104736532B (es)
AU (2) AU2013336807B2 (es)
BR (1) BR112015007243B1 (es)
CA (1) CA2885471C (es)
ES (1) ES2605638T3 (es)
IN (1) IN2015DN01331A (es)
MX (1) MX360703B (es)
PL (1) PL2912030T3 (es)
PT (1) PT2912030T (es)
RU (1) RU2646760C2 (es)
WO (1) WO2014064058A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX342326B (es) 2011-09-27 2016-09-26 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
WO2014110466A1 (en) * 2013-01-12 2014-07-17 Dawei Zhang Pyridine compounds used as pi3 kinase inhibitors
PE20151939A1 (es) 2013-03-14 2016-01-08 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante
SG11201608658SA (en) 2014-04-22 2016-11-29 Univ Basel Novel manufacturing process for triazine, pyrimidine and pyridine derivatives
WO2016050201A1 (zh) * 2014-09-29 2016-04-07 山东轩竹医药科技有限公司 高选择性取代嘧啶类pi3k抑制剂
CN105085476B (zh) * 2014-11-24 2018-03-09 苏州晶云药物科技有限公司 5‑[2,6‑二(4‑吗啉基)‑4‑嘧啶基]‑4‑(三氟甲基)‑2‑吡啶胺二盐酸盐的晶型及其制备方法
CN105001151B (zh) * 2015-08-28 2017-07-14 苏州明锐医药科技有限公司 布帕尼西中间体及其制备方法
CN106543140A (zh) * 2015-09-21 2017-03-29 苏州晶云药物科技有限公司 5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺盐酸盐的晶型及其制备方法
CN107793394A (zh) * 2017-08-03 2018-03-13 上海厚璞生物科技有限公司 一种生产选择性pi3k抑制剂的系列关键中间体
CA3122182A1 (en) * 2018-12-18 2020-06-25 Astrazeneca Ab Pharmaceutical process and intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4061194B2 (ja) * 2001-02-08 2008-03-12 富山化学工業株式会社 ６−置換アルキルアミノ−３−ピリジルホウ酸誘導体またはその塩およびそれらの製造法
US7423148B2 (en) * 2002-11-21 2008-09-09 Chiron Corporation Small molecule PI 3-kinase inhibitors and methods of their use
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
RU2015150728A (ru) * 2010-10-01 2019-01-15 Новартис Аг Способ получения пиримидиновых производных

Also Published As

Publication number Publication date
JP6267213B2 (ja) 2018-01-24
US9637468B2 (en) 2017-05-02
CN104736532B (zh) 2017-04-05
KR20150072408A (ko) 2015-06-29
BR112015007243B1 (pt) 2022-02-08
MX2015005188A (es) 2015-09-07
EP2912030B1 (en) 2016-08-31
CN104736532A (zh) 2015-06-24
RU2015119259A (ru) 2016-12-20
WO2014064058A1 (en) 2014-05-01
IN2015DN01331A (es) 2015-07-03
RU2646760C2 (ru) 2018-03-07
CA2885471A1 (en) 2014-05-01
CA2885471C (en) 2021-02-23
JP2016502510A (ja) 2016-01-28
PL2912030T3 (pl) 2017-02-28
AU2013336807B2 (en) 2016-10-27
PT2912030T (pt) 2016-11-30
ES2605638T3 (es) 2017-03-15
AU2013336807A1 (en) 2015-03-05
US20150246897A1 (en) 2015-09-03
KR102128127B1 (ko) 2020-06-30
EP2912030A1 (en) 2015-09-02
AU2016238941A1 (en) 2016-11-03
BR112015007243A2 (pt) 2017-07-04

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