JP2004512263A - オピオイド受容体親和性を有する３−アザビシクロ（３．１．０）ヘキサン誘導体 - Google Patents
オピオイド受容体親和性を有する３−アザビシクロ（３．１．０）ヘキサン誘導体 Download PDFInfo
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- JP2004512263A JP2004512263A JP2002504223A JP2002504223A JP2004512263A JP 2004512263 A JP2004512263 A JP 2004512263A JP 2002504223 A JP2002504223 A JP 2002504223A JP 2002504223 A JP2002504223 A JP 2002504223A JP 2004512263 A JP2004512263 A JP 2004512263A
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- alkyl
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- heteroaryl
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- cycloalkyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0015562.2A GB0015562D0 (en) | 2000-06-23 | 2000-06-23 | Heterocycles |
| PCT/IB2001/001035 WO2001098267A1 (en) | 2000-06-23 | 2001-06-07 | 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2004512263A true JP2004512263A (ja) | 2004-04-22 |
Family
ID=9894368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002504223A Withdrawn JP2004512263A (ja) | 2000-06-23 | 2001-06-07 | オピオイド受容体親和性を有する３−アザビシクロ（３．１．０）ヘキサン誘導体 |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1292574A1 (es) |
| JP (1) | JP2004512263A (es) |
| KR (1) | KR20040002386A (es) |
| CN (1) | CN1639121A (es) |
| AP (1) | AP2002002698A0 (es) |
| AR (1) | AR028969A1 (es) |
| AU (1) | AU781837B2 (es) |
| BG (1) | BG107329A (es) |
| BR (1) | BR0111867A (es) |
| CA (1) | CA2412188A1 (es) |
| CZ (1) | CZ20023967A3 (es) |
| DO (1) | DOP2001000187A (es) |
| DZ (1) | DZ3368A1 (es) |
| EA (1) | EA005117B1 (es) |
| GB (1) | GB0015562D0 (es) |
| HR (1) | HRP20020998A2 (es) |
| HU (1) | HUP0301228A3 (es) |
| IL (1) | IL153427A0 (es) |
| IS (1) | IS6637A (es) |
| MA (1) | MA26915A1 (es) |
| MX (1) | MXPA02012878A (es) |
| NO (1) | NO20026168L (es) |
| NZ (1) | NZ523141A (es) |
| OA (1) | OA12293A (es) |
| PA (1) | PA8519401A1 (es) |
| PE (1) | PE20020253A1 (es) |
| PL (1) | PL365956A1 (es) |
| SK (1) | SK17172002A3 (es) |
| TN (1) | TNSN01094A1 (es) |
| UA (1) | UA73176C2 (es) |
| UY (1) | UY26787A1 (es) |
| WO (1) | WO2001098267A1 (es) |
| YU (1) | YU91802A (es) |
| ZA (1) | ZA200210278B (es) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008535888A (ja) * | 2005-04-15 | 2008-09-04 | グラクソ グループ リミテッド | ドーパミンｄ３受容体のモジュレーターとして有用なアザビシクロ（３．１．０）ヘキサン誘導体 |
| JP2008543801A (ja) * | 2005-06-14 | 2008-12-04 | グラクソ グループ リミテッド | ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体 |
| JP2010537978A (ja) * | 2007-08-27 | 2010-12-09 | セラヴァンス， インコーポレーテッド | μオピオイド受容体拮抗薬としての８−アザビシクロ［３．２．１］オクチル−２−ヒドロキシベンズアミド化合物 |
| JP2015107980A (ja) * | 2010-06-11 | 2015-06-11 | ローズ テクノロジーズ | Ｎ−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用 |
| JP2020508300A (ja) * | 2017-02-17 | 2020-03-19 | トレベナ・インコーポレイテッドＴｒｅｖｅｎａ， Ｉｎｃ． | ５員アザ複素環を含有するデルタ−オピオイド受容体調節化合物、その使用方法及び製造方法 |
| US11912713B2 (en) | 2017-02-17 | 2024-02-27 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2463264C (en) * | 2001-10-22 | 2009-05-26 | Pfizer Products Inc. | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
| CN100411618C (zh) * | 2002-05-17 | 2008-08-20 | 迪欧加药品公司 | 有效的选择性阿片受体调制剂化合物的用途 |
| DE10259245A1 (de) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivate des Asimadolins mit kovalent gebundenen Säuren |
| US7855298B2 (en) | 2004-02-23 | 2010-12-21 | Glaxo Group Limited | Azabicyclo (3.1.0.) hexane derivatives useful as modulators of dopamine D3 receptors |
| ATE498619T1 (de) * | 2006-04-03 | 2011-03-15 | Glaxo Group Ltd | Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren |
| CN101677997B (zh) | 2007-03-30 | 2012-05-09 | 泰奥加制药公司 | 用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂 |
| BR112013007566A2 (pt) | 2010-09-28 | 2016-08-02 | Panacea Biotec Ltd | novos compostos bicíclicos |
| DK3072884T3 (da) * | 2013-11-20 | 2020-03-09 | Sanwa Kagaku Kenkyusho Co | 3-azabicyclo[3.1.0]hexanderivat og anvendelse deraf til medicinske formål |
| EP3299357A4 (en) | 2015-05-20 | 2018-11-14 | Sanwa Kagaku Kenkyusho Co., Ltd. | Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof |
| US20200237720A1 (en) | 2017-03-02 | 2020-07-30 | Sanwa Kagaku Kenkyusho Co., Ltd. | Therapeutic agent for alcohol use disorders |
| CN108250088B (zh) * | 2018-01-04 | 2020-10-30 | 四川之江高新材料股份有限公司 | N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法 |
| CN115825305B (zh) * | 2022-10-21 | 2024-09-20 | 昆明理工大学 | 一种分子印迹固相微萃取纤维及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065230A (en) * | 1959-03-16 | 1962-11-20 | Burroughs Wellcome Co | Azabicyclohexanes and method of preparing them |
| NZ224236A (en) * | 1987-04-16 | 1990-08-28 | Lilly Co Eli | Trans 3,4 pyridine derivatives and pharmaceutical compositions |
| US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
-
2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
-
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Application Discontinuation
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/xx active
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 PL PL01365956A patent/PL365956A1/xx not_active Application Discontinuation
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Application Discontinuation
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
-
2002
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-12-12 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008535888A (ja) * | 2005-04-15 | 2008-09-04 | グラクソ グループ リミテッド | ドーパミンｄ３受容体のモジュレーターとして有用なアザビシクロ（３．１．０）ヘキサン誘導体 |
| JP2008543801A (ja) * | 2005-06-14 | 2008-12-04 | グラクソ グループ リミテッド | ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体 |
| JP2010537978A (ja) * | 2007-08-27 | 2010-12-09 | セラヴァンス， インコーポレーテッド | μオピオイド受容体拮抗薬としての８−アザビシクロ［３．２．１］オクチル−２−ヒドロキシベンズアミド化合物 |
| JP2015107980A (ja) * | 2010-06-11 | 2015-06-11 | ローズ テクノロジーズ | Ｎ−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用 |
| US9499557B2 (en) | 2010-06-11 | 2016-11-22 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
| US9593124B2 (en) | 2010-06-11 | 2017-03-14 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
| US9624232B2 (en) | 2010-06-11 | 2017-04-18 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
| US9657030B2 (en) | 2010-06-11 | 2017-05-23 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
| JP2020508300A (ja) * | 2017-02-17 | 2020-03-19 | トレベナ・インコーポレイテッドＴｒｅｖｅｎａ， Ｉｎｃ． | ５員アザ複素環を含有するデルタ−オピオイド受容体調節化合物、その使用方法及び製造方法 |
| US11702408B2 (en) | 2017-02-17 | 2023-07-18 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| JP7316216B2 (ja) | 2017-02-17 | 2023-07-27 | トレベナ・インコーポレイテッド | ５員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法 |
| US11912713B2 (en) | 2017-02-17 | 2024-02-27 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
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| A761 | Written withdrawal of application |
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