PE20030763A1 - Inhibidores de la integrasa del vih - Google Patents
Inhibidores de la integrasa del vihInfo
- Publication number
- PE20030763A1 PE20030763A1 PE2002001198A PE2002001198A PE20030763A1 PE 20030763 A1 PE20030763 A1 PE 20030763A1 PE 2002001198 A PE2002001198 A PE 2002001198A PE 2002001198 A PE2002001198 A PE 2002001198A PE 20030763 A1 PE20030763 A1 PE 20030763A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aryl
- metoxy
- carbamoyl
- cycloalkyl
- Prior art date
Links
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- -1 4-FLUORO-BENZYL Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C207/00—Compounds containing nitroso groups bound to a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C207/00—Compounds containing nitroso groups bound to a carbon skeleton
- C07C207/04—Compounds containing nitroso groups bound to a carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/08—Hydroxylamino compounds or their ethers or esters
- C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
- C07C255/64—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I DONDE R1 ES ARILO, ALQUILO C1-C6-ARILO, ALQUILO C1-C6-S(O)n-ARILO, ALQUILO C1-C5-O-ARILO Y DONDE R1 ESTA SIN SUSTITUIR O SUSTITUIDO SON H, HALO, CN, ALQUILO C1-C6, CICLOALQUILO C3-C6, OR4, ALQUILO C1-C10-O-R4, CO2R5, ENTRE OTROS; R2 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C6, HALOALQUILO C1-C10, ARILO, HETEROARILO, ENTRE OTROS; R4-R6 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; B1 ES EN GRUPO a, b, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO 3-[(4-FLUORO-BENCIL)-METOXI-CARBAMOIL]-2-HIDROXI-ACRILICO, ACIDO 3-[(3,4-DIFLUORO-BENCIL)-METOXI-CARBAMOIL]-2-HIDROXI-ACRILICO, ACIDO 3-[(3-BROMO-4-FLUORO-BENCIL)-METOXI-CARBAMOIL]-2-HIDROXI-ACRILICO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA INTEGRASA DEL VIH Y SON UTILES PARA EL TRATAMIENTO DEL VIH
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33967401P | 2001-12-12 | 2001-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030763A1 true PE20030763A1 (es) | 2003-09-13 |
Family
ID=23330105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002001198A PE20030763A1 (es) | 2001-12-12 | 2002-12-12 | Inhibidores de la integrasa del vih |
Country Status (24)
Country | Link |
---|---|
US (1) | US6777440B2 (es) |
EP (1) | EP1467695A2 (es) |
JP (1) | JP2005515206A (es) |
KR (1) | KR20040065251A (es) |
CN (1) | CN1617849A (es) |
AR (1) | AR037770A1 (es) |
AU (1) | AU2002366604A1 (es) |
BR (1) | BR0214842A (es) |
CA (1) | CA2469592C (es) |
CO (1) | CO5590909A2 (es) |
HR (1) | HRP20040534A2 (es) |
HU (1) | HUP0402675A2 (es) |
IL (1) | IL162325A0 (es) |
IS (1) | IS7305A (es) |
MX (1) | MXPA04005623A (es) |
NO (1) | NO20042916L (es) |
NZ (1) | NZ533413A (es) |
PE (1) | PE20030763A1 (es) |
PL (1) | PL370664A1 (es) |
RU (1) | RU2284315C2 (es) |
TW (1) | TWI252757B (es) |
UY (1) | UY27577A1 (es) |
WO (1) | WO2003049690A2 (es) |
ZA (1) | ZA200404628B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7169932B2 (en) | 2001-06-11 | 2007-01-30 | Pfizer Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis |
US7094909B2 (en) | 2001-06-11 | 2006-08-22 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis |
HN2002000136A (es) | 2001-06-11 | 2003-07-31 | Basf Ag | Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis |
PA8586801A1 (es) | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
BRPI0407052A (pt) | 2003-01-27 | 2006-01-17 | Pfizer | Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização |
US6890942B2 (en) * | 2003-05-16 | 2005-05-10 | Bristol-Myers Squibb Company | Acyl sulfonamides as inhibitors of HIV integrase |
US20050215544A1 (en) * | 2004-03-24 | 2005-09-29 | Pin-Fang Lin | Methods of treating HIV infection |
US7776863B2 (en) * | 2004-03-24 | 2010-08-17 | Bristol-Myers Squibb Company | Methods of treating HIV infection |
EP1756103A2 (en) | 2004-04-26 | 2007-02-28 | Pfizer, Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
CA2563761C (en) | 2004-04-26 | 2009-12-29 | Pfizer Inc. | Inhibitors of the hiv integrase enzyme |
US7507838B2 (en) * | 2004-09-01 | 2009-03-24 | Bristol-Myers Squibb Company | Process for the preparation of Z-5-carboxymethylene-1,3-dioxolan-4-ones |
US20060058286A1 (en) * | 2004-09-16 | 2006-03-16 | Mark Krystal | Methods of treating HIV infection |
WO2007086584A1 (ja) * | 2006-01-30 | 2007-08-02 | Meiji Seika Kaisha, Ltd. | 新規FabKおよびFabI/K阻害剤 |
WO2008004100A2 (en) | 2006-07-05 | 2008-01-10 | Pfizer Products Inc. | Therapeutic compounds |
CA2744509C (en) * | 2008-12-05 | 2013-10-22 | Syngenta Participations Ag | Novel pyrazole-4-n-alkoxycarboxamides as microbiocides |
WO2011076765A1 (en) | 2009-12-23 | 2011-06-30 | Katholieke Universiteit Leuven | Novel antiviral compounds |
US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
WO2012065963A2 (en) | 2010-11-15 | 2012-05-24 | Katholieke Universiteit Leuven | Novel antiviral compounds |
EP2640729B1 (en) | 2010-11-15 | 2016-12-21 | VIIV Healthcare UK Limited | Inhibitors of hiv replication |
IN2014DN09934A (es) * | 2012-04-26 | 2015-08-14 | Bayer Cropscience Ag |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR029304A1 (es) * | 1998-06-26 | 2003-06-25 | Daiichi Seiyaku Co | DERIVADOS DE PROPIONILO SUSTITUIDOS, PRODUCTO FARMACEUTICO, USO PARA LA FABRICACION DE UNA COMPOSICION FARMACEUTICA PARA LA PREVENCION Y/O TRATAMIENTO DE HIPERCOLESTEROLEMIA, HIPERLIPEMIA O ARTERIOESCLEROSIS, COMPOSICIoN FARMACÉUTICA Y COMPUESTOS INTERMEDIARIOS |
-
2002
- 2002-12-06 KR KR10-2004-7009018A patent/KR20040065251A/ko not_active Application Discontinuation
- 2002-12-06 TW TW091135471A patent/TWI252757B/zh not_active IP Right Cessation
- 2002-12-06 MX MXPA04005623A patent/MXPA04005623A/es unknown
- 2002-12-06 AU AU2002366604A patent/AU2002366604A1/en not_active Abandoned
- 2002-12-06 WO PCT/US2002/039092 patent/WO2003049690A2/en not_active Application Discontinuation
- 2002-12-06 IL IL16232502A patent/IL162325A0/xx unknown
- 2002-12-06 CN CNA028279700A patent/CN1617849A/zh active Pending
- 2002-12-06 CA CA002469592A patent/CA2469592C/en not_active Expired - Fee Related
- 2002-12-06 JP JP2003550741A patent/JP2005515206A/ja not_active Withdrawn
- 2002-12-06 EP EP02804741A patent/EP1467695A2/en not_active Withdrawn
- 2002-12-06 BR BR0214842-0A patent/BR0214842A/pt not_active Withdrawn
- 2002-12-06 US US10/313,058 patent/US6777440B2/en not_active Expired - Lifetime
- 2002-12-06 HU HU0402675A patent/HUP0402675A2/hu unknown
- 2002-12-06 RU RU2004119963/04A patent/RU2284315C2/ru not_active IP Right Cessation
- 2002-12-06 PL PL02370664A patent/PL370664A1/xx not_active Application Discontinuation
- 2002-12-06 NZ NZ533413A patent/NZ533413A/en unknown
- 2002-12-10 AR ARP020104777A patent/AR037770A1/es not_active Application Discontinuation
- 2002-12-11 UY UY27577A patent/UY27577A1/es not_active Application Discontinuation
- 2002-12-12 PE PE2002001198A patent/PE20030763A1/es not_active Application Discontinuation
-
2004
- 2004-06-09 CO CO04054295A patent/CO5590909A2/es not_active Application Discontinuation
- 2004-06-10 IS IS7305A patent/IS7305A/is unknown
- 2004-06-10 ZA ZA200404628A patent/ZA200404628B/en unknown
- 2004-06-11 HR HR20040534A patent/HRP20040534A2/hr not_active Application Discontinuation
- 2004-07-09 NO NO20042916A patent/NO20042916L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA04005623A (es) | 2004-12-06 |
PL370664A1 (en) | 2005-05-30 |
US6777440B2 (en) | 2004-08-17 |
TWI252757B (en) | 2006-04-11 |
TW200301105A (en) | 2003-07-01 |
KR20040065251A (ko) | 2004-07-21 |
WO2003049690A3 (en) | 2004-01-22 |
HUP0402675A2 (hu) | 2005-03-29 |
CO5590909A2 (es) | 2005-12-30 |
RU2284315C2 (ru) | 2006-09-27 |
IS7305A (is) | 2004-06-10 |
UY27577A1 (es) | 2003-07-31 |
AR037770A1 (es) | 2004-12-01 |
NZ533413A (en) | 2006-09-29 |
CA2469592A1 (en) | 2003-06-19 |
NO20042916L (no) | 2004-09-10 |
RU2004119963A (ru) | 2006-01-10 |
IL162325A0 (en) | 2005-11-20 |
HRP20040534A2 (en) | 2005-04-30 |
WO2003049690A2 (en) | 2003-06-19 |
EP1467695A2 (en) | 2004-10-20 |
CN1617849A (zh) | 2005-05-18 |
BR0214842A (pt) | 2005-01-11 |
CA2469592C (en) | 2005-08-23 |
US20030176495A1 (en) | 2003-09-18 |
AU2002366604A1 (en) | 2003-06-23 |
JP2005515206A (ja) | 2005-05-26 |
ZA200404628B (en) | 2005-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |