ES2177816T3 - Derivados de azahexano como isosteros de sustrato de aspartato proteasas retroviricas. - Google Patents

Derivados de azahexano como isosteros de sustrato de aspartato proteasas retroviricas.

Info

Publication number
ES2177816T3
ES2177816T3 ES96939024T ES96939024T ES2177816T3 ES 2177816 T3 ES2177816 T3 ES 2177816T3 ES 96939024 T ES96939024 T ES 96939024T ES 96939024 T ES96939024 T ES 96939024T ES 2177816 T3 ES2177816 T3 ES 2177816T3
Authority
ES
Spain
Prior art keywords
retroviricas
proteasas
isosteros
azahexano
aspartato
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96939024T
Other languages
English (en)
Inventor
Alexander Fassler
Guido Bold
Hans-Georg Capraro
Marc Lang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2177816T3 publication Critical patent/ES2177816T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I); DONDE R 1 Y R 10 SON, CADA UNO INDEPENDIENTEMENTE DEL OTRO, ALCOXICARBONILO INFERIOR; R 2 , R 3 O R 4 SON, CADA UNO INDEPENDIENTEMENTE DEL RESTO, ALQUILO C 1 - C SUB,4 Y R 7 , R 8 Y R 9 SE SELECCIONAN CADA UNO INDEPENDIENTEMENTE A PARTIR DE HIROGENO Y ALQUILO C 1 C SUB,4 , SIENDO NO MAS DE DOS RADICALES HIDROGENO; O R 7 , R 8 Y R 9 SON, CADA UNO INDEPENDIENTEMENTE DEL OTRO, ALQUILO C 1 - C 4 Y R 2 , R 3 Y R 4 SE SELECCIONAN CADA UNO A PARTIR DE HIDROGENO Y ALQUILO C 1 C 4 , SIENDO 1 O 2 DE LOS RADICALES HIDROGENO; R 5 ES FENILO O CICLOHEXILO; Y R 6 ES FENILO O CIANOFENILO; O LAS SALES DE LOS MISMOS. DICHOS COMPUESTOS SON INHIBIDORES DE LAS PROTEASAS DE ASPARTATO VIRALES Y SON EFECTIVOS, POR EJEMPLO, FRENTE AL VIH.
ES96939024T 1995-11-21 1996-11-13 Derivados de azahexano como isosteros de sustrato de aspartato proteasas retroviricas. Expired - Lifetime ES2177816T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH329695 1995-11-21
CH168696 1996-07-05

Publications (1)

Publication Number Publication Date
ES2177816T3 true ES2177816T3 (es) 2002-12-16

Family

ID=25688382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96939024T Expired - Lifetime ES2177816T3 (es) 1995-11-21 1996-11-13 Derivados de azahexano como isosteros de sustrato de aspartato proteasas retroviricas.

Country Status (9)

Country Link
US (1) US6225345B1 (es)
EP (1) EP0876336B1 (es)
JP (1) JPH11514996A (es)
AT (1) ATE218538T1 (es)
AU (1) AU7623796A (es)
CA (1) CA2237016A1 (es)
DE (1) DE69621651T2 (es)
ES (1) ES2177816T3 (es)
WO (1) WO1997019055A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2959397A (en) * 1996-05-31 1998-01-05 Novartis Ag Process for the preparation of hydrazine derivatives useful as intermediates for the preparation of peptide analogues
PT1088098E (pt) * 1998-06-23 2011-05-25 Univ Illinois Medicamento para tratar mam?feros infectados com hiv
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
ATE302751T1 (de) * 2000-06-30 2005-09-15 Elan Pharm Inc Verbindungen zur behandlung der alzheimerischen krankheit
BR0209985A (pt) * 2001-05-22 2004-06-29 Elan Pharm Inc Composto e método para o tratamento de um paciente
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
ATE539074T1 (de) * 2003-12-11 2012-01-15 Abbott Lab Die hiv-protease hemmende verbindungen
MXPA06006609A (es) * 2003-12-11 2006-08-31 Abbott Lab Compuestos inhibidores de proteasa de vih.
US7713885B2 (en) * 2005-05-11 2010-05-11 Micron Technology, Inc. Methods of etching oxide, reducing roughness, and forming capacitor constructions
NZ573887A (en) 2006-07-21 2012-02-24 Gilead Sciences Inc Antiviral protease inhibitors
WO2011080562A1 (en) 2009-12-29 2011-07-07 Hetero Research Foundation Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
TWI829205B (zh) 2018-07-30 2024-01-11 美商基利科學股份有限公司 抗hiv化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89900A0 (en) 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
ES2093237T3 (es) * 1991-07-03 1996-12-16 Ciba Geigy Ag Derivados de hidrazina farmacologicamente activos y procedimiento para su obtencion.
DK0604368T3 (es) * 1992-12-23 1997-02-24 Ciba Geigy Ag
US5461067A (en) 1993-02-25 1995-10-24 Abbott Laboratories Retroviral protease inhibiting compounds
US5538997A (en) 1993-03-12 1996-07-23 Sandoz Ltd. 2,4-diamino-3-hydroxycarboxylic acid derivatives

Also Published As

Publication number Publication date
EP0876336A1 (en) 1998-11-11
WO1997019055A1 (en) 1997-05-29
DE69621651T2 (de) 2002-11-21
ATE218538T1 (de) 2002-06-15
EP0876336B1 (en) 2002-06-05
AU7623796A (en) 1997-06-11
JPH11514996A (ja) 1999-12-21
US6225345B1 (en) 2001-05-01
CA2237016A1 (en) 1997-05-29
DE69621651D1 (de) 2002-07-11

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