DE69621651D1 - Azahexan-derivate als substratisostere von retroviralen aspartat-proteasen - Google Patents
Azahexan-derivate als substratisostere von retroviralen aspartat-proteasenInfo
- Publication number
- DE69621651D1 DE69621651D1 DE69621651T DE69621651T DE69621651D1 DE 69621651 D1 DE69621651 D1 DE 69621651D1 DE 69621651 T DE69621651 T DE 69621651T DE 69621651 T DE69621651 T DE 69621651T DE 69621651 D1 DE69621651 D1 DE 69621651D1
- Authority
- DE
- Germany
- Prior art keywords
- substratisosteres
- azahexan
- derivatives
- aspartate proteases
- c4alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Prostheses (AREA)
- Helmets And Other Head Coverings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH329695 | 1995-11-21 | ||
CH168696 | 1996-07-05 | ||
PCT/EP1996/004968 WO1997019055A1 (en) | 1995-11-21 | 1996-11-13 | Azahexane derivatives as substrate isosters of retroviral asparate proteases |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69621651D1 true DE69621651D1 (de) | 2002-07-11 |
DE69621651T2 DE69621651T2 (de) | 2002-11-21 |
Family
ID=25688382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69621651T Expired - Fee Related DE69621651T2 (de) | 1995-11-21 | 1996-11-13 | Azahexan-derivate als substratisostere von retroviralen aspartat-proteasen |
Country Status (9)
Country | Link |
---|---|
US (1) | US6225345B1 (de) |
EP (1) | EP0876336B1 (de) |
JP (1) | JPH11514996A (de) |
AT (1) | ATE218538T1 (de) |
AU (1) | AU7623796A (de) |
CA (1) | CA2237016A1 (de) |
DE (1) | DE69621651T2 (de) |
ES (1) | ES2177816T3 (de) |
WO (1) | WO1997019055A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2959397A (en) * | 1996-05-31 | 1998-01-05 | Novartis Ag | Process for the preparation of hydrazine derivatives useful as intermediates for the preparation of peptide analogues |
AU4828199A (en) * | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
PT2336134T (pt) * | 1998-06-23 | 2016-10-19 | The Board Of Trustees Of The Univ Of Illionis | Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia |
AU2001273113A1 (en) * | 2000-06-30 | 2002-01-14 | Elan Pharmaceuticals, Inc | Compounds to treat alzheimer's disease |
EP1392645A2 (de) * | 2001-05-22 | 2004-03-03 | Elan Pharmaceuticals, Inc. | Aza-hydroxylierte-ethylamin-verbindungen |
US7157489B2 (en) | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
JP5005351B2 (ja) * | 2003-12-11 | 2012-08-22 | アボット・ラボラトリーズ | Hivプロテアーゼ阻害性化合物 |
MXPA06006609A (es) * | 2003-12-11 | 2006-08-31 | Abbott Lab | Compuestos inhibidores de proteasa de vih. |
US7713885B2 (en) * | 2005-05-11 | 2010-05-11 | Micron Technology, Inc. | Methods of etching oxide, reducing roughness, and forming capacitor constructions |
CA2657936C (en) * | 2006-07-21 | 2017-01-10 | Gilead Sciences, Inc. | Antiviral protease inhibitors |
WO2011080562A1 (en) | 2009-12-29 | 2011-07-07 | Hetero Research Foundation | Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals |
JOP20180009A1 (ar) | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
TWI829205B (zh) | 2018-07-30 | 2024-01-11 | 美商基利科學股份有限公司 | 抗hiv化合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
ATE143355T1 (de) | 1991-07-03 | 1996-10-15 | Ciba Geigy Ag | Pharmakologisch wirksame hydrazinderivate und verfahren zu deren herstellung |
EP0604368B1 (de) | 1992-12-23 | 1996-09-18 | Ciba-Geigy Ag | Antiretrovirale hydrazinderivate |
US5461067A (en) | 1993-02-25 | 1995-10-24 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US5538997A (en) * | 1993-03-12 | 1996-07-23 | Sandoz Ltd. | 2,4-diamino-3-hydroxycarboxylic acid derivatives |
-
1996
- 1996-11-13 WO PCT/EP1996/004968 patent/WO1997019055A1/en active IP Right Grant
- 1996-11-13 CA CA002237016A patent/CA2237016A1/en not_active Abandoned
- 1996-11-13 US US09/068,876 patent/US6225345B1/en not_active Expired - Fee Related
- 1996-11-13 ES ES96939024T patent/ES2177816T3/es not_active Expired - Lifetime
- 1996-11-13 DE DE69621651T patent/DE69621651T2/de not_active Expired - Fee Related
- 1996-11-13 JP JP9514529A patent/JPH11514996A/ja not_active Ceased
- 1996-11-13 AU AU76237/96A patent/AU7623796A/en not_active Abandoned
- 1996-11-13 EP EP96939024A patent/EP0876336B1/de not_active Expired - Lifetime
- 1996-11-13 AT AT96939024T patent/ATE218538T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU7623796A (en) | 1997-06-11 |
US6225345B1 (en) | 2001-05-01 |
CA2237016A1 (en) | 1997-05-29 |
WO1997019055A1 (en) | 1997-05-29 |
EP0876336B1 (de) | 2002-06-05 |
ATE218538T1 (de) | 2002-06-15 |
ES2177816T3 (es) | 2002-12-16 |
JPH11514996A (ja) | 1999-12-21 |
EP0876336A1 (de) | 1998-11-11 |
DE69621651T2 (de) | 2002-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |