DK0540956T3 - Fremgangsmåde til fremstilling af substituerede maleinimider - Google Patents
Fremgangsmåde til fremstilling af substituerede maleinimiderInfo
- Publication number
- DK0540956T3 DK0540956T3 DK92118164.0T DK92118164T DK0540956T3 DK 0540956 T3 DK0540956 T3 DK 0540956T3 DK 92118164 T DK92118164 T DK 92118164T DK 0540956 T3 DK0540956 T3 DK 0540956T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- chem
- alkyl
- aryl
- above significance
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919123396A GB9123396D0 (en) | 1991-11-04 | 1991-11-04 | A process for the manufacture of substituted maleimides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0540956T3 true DK0540956T3 (da) | 1998-04-14 |
Family
ID=10704041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92118164.0T DK0540956T3 (da) | 1991-11-04 | 1992-10-23 | Fremgangsmåde til fremstilling af substituerede maleinimider |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5399712A (da) |
| EP (1) | EP0540956B1 (da) |
| JP (1) | JP2799271B2 (da) |
| CN (1) | CN1041308C (da) |
| AT (1) | ATE157664T1 (da) |
| AU (1) | AU658017B2 (da) |
| CA (1) | CA2081805C (da) |
| DE (1) | DE69221988T2 (da) |
| DK (1) | DK0540956T3 (da) |
| ES (1) | ES2107487T3 (da) |
| GB (1) | GB9123396D0 (da) |
| GR (1) | GR3025396T3 (da) |
| NZ (1) | NZ244952A (da) |
| ZA (1) | ZA928340B (da) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374727A (en) * | 1992-06-19 | 1994-12-20 | Hoffmann-La Roche Inc. | Asymmetric hydrogenation of dihydro-pyrido [1,2-a]indoles |
| US5721230A (en) * | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| PT657458E (pt) * | 1993-12-07 | 2002-02-28 | Lilly Co Eli | Inibidores de proteina cinase c |
| US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
| US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
| DK0657411T3 (da) * | 1993-12-07 | 1999-11-15 | Lilly Co Eli | Forbedret syntese af bisindolylmaleimider |
| ATE456367T1 (de) * | 1993-12-23 | 2010-02-15 | Lilly Co Eli | Proteinkinase c inhibitoren |
| US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| KR20000064764A (ko) * | 1996-03-20 | 2000-11-06 | 피터지.스트링거 | 인돌릴말레이미드의제조방법 |
| CN1228082A (zh) * | 1996-08-23 | 1999-09-08 | 伊莱利利公司 | 双吲哚基马来酰亚胺的合成 |
| SE9603283D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
| TW472045B (en) * | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
| US5859261A (en) * | 1997-03-20 | 1999-01-12 | Eli Lilly And Company | Synthesis of indolylmaleimides |
| US6133452A (en) * | 1997-08-22 | 2000-10-17 | Eli Lilly And Company | Synthesis of bisindolylmalimides |
| AR017200A1 (es) | 1997-12-23 | 2001-08-22 | Astrazeneca Ab | Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos |
| SE9800835D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| HUP0103381A3 (en) * | 1998-07-30 | 2002-07-29 | Japan Tobacco Inc | Disubstituted maleimide compounds and medicinal utilization thereof and the pharmaceutical compositions containing the same |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| US6284783B1 (en) | 1999-06-09 | 2001-09-04 | The Uab Research Foundation | Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis |
| US6346625B1 (en) | 1999-06-23 | 2002-02-12 | Astrazeneca Ab | Protein kinase inhibitors |
| WO2001013916A1 (fr) * | 1999-08-20 | 2001-03-01 | Sagami Chemical Research Center | Medicaments inhibant la mort cellulaire |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| RU2003104796A (ru) | 2000-07-27 | 2004-08-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные 3-индолил-4-фенил-1н-пиррол-2, 5-диона в качестве ингибиторов гликогенсинтазы-киназы-3 бета |
| US6645970B2 (en) | 2000-11-07 | 2003-11-11 | Novartis Ag | Indolylmaleimide derivatives |
| ATE318596T1 (de) * | 2001-03-29 | 2006-03-15 | Topotarget As | Succinimid- und maleimidderivate und ihre verwendung als katalytische inhibitoren der topoisomerase ii |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| DK1397130T3 (da) | 2001-06-20 | 2007-11-12 | Wyeth Corp | Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) |
| TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
| CA2393720C (en) | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
| MXPA05006288A (es) | 2002-12-10 | 2005-08-19 | Wyeth Corp | Derivados del acido 3-carbonil-1h-indol-1-ilacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1). |
| ATE411288T1 (de) * | 2002-12-10 | 2008-10-15 | Wyeth Corp | Aryl-, aryloxy- und alkyloxysubstituierte 1h- indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| AU2003297727A1 (en) | 2002-12-10 | 2004-06-30 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| JP2006510672A (ja) | 2002-12-10 | 2006-03-30 | ワイス | プラスミノーゲン活性化因子の阻害因子−１（ｐａｉ−１）の阻害剤としての置換インドールオキソ−アセチルアミノ酢酸誘導体 |
| GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| MX2007002178A (es) | 2004-08-23 | 2007-04-02 | Wyeth Corp | Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares. |
| AU2005277139A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1 |
| BRPI0514549A (pt) | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de pirrol-naftila como inibidores de pai-1 |
| EP1819697B1 (en) | 2004-12-08 | 2012-08-01 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
| KR20080023732A (ko) | 2005-07-11 | 2008-03-14 | 노파르티스 아게 | 인돌릴말레이미드 유도체 |
| JP2009504762A (ja) | 2005-08-17 | 2009-02-05 | ワイス | 置換インドール類およびそれらの使用方法 |
| KR101061764B1 (ko) * | 2008-02-29 | 2011-09-05 | (주)에스에이치제약 | 신경보호효과를 가지는 피루베이트 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| EP2343291A1 (en) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| WO2012143468A1 (en) * | 2011-04-21 | 2012-10-26 | Basf Se | 3,4-disubstituted pyrrole 2,5-diones and their use as fungicides |
| JP2017524739A (ja) | 2014-07-17 | 2017-08-31 | アンセルムＩｎｓｅｒｍ | 神経筋接合部関連疾患の処置方法 |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4332822A (en) * | 1980-02-05 | 1982-06-01 | John Wyeth & Brother Limited | Guanidine derivatives |
| DE3631414A1 (de) * | 1986-09-16 | 1988-03-24 | Basf Ag | Verfahren zur herstellung von (alpha)-pyrrolidonen, deren verwendung und neue (alpha)-pyrrolidone |
| DE3707719A1 (de) * | 1987-03-11 | 1988-09-22 | Degussa | Verfahren zur herstellung von (r)-4-amino-3-hydroxybutansaeure (gabob) |
| SK278989B6 (sk) * | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
| MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
-
1991
- 1991-11-04 GB GB919123396A patent/GB9123396D0/en active Pending
-
1992
- 1992-10-23 EP EP92118164A patent/EP0540956B1/en not_active Expired - Lifetime
- 1992-10-23 ES ES92118164T patent/ES2107487T3/es not_active Expired - Lifetime
- 1992-10-23 DE DE69221988T patent/DE69221988T2/de not_active Expired - Fee Related
- 1992-10-23 DK DK92118164.0T patent/DK0540956T3/da active
- 1992-10-23 AT AT92118164T patent/ATE157664T1/de not_active IP Right Cessation
- 1992-10-28 ZA ZA928340A patent/ZA928340B/xx unknown
- 1992-10-29 AU AU27419/92A patent/AU658017B2/en not_active Ceased
- 1992-10-30 CA CA002081805A patent/CA2081805C/en not_active Expired - Fee Related
- 1992-10-30 NZ NZ244952A patent/NZ244952A/en not_active IP Right Cessation
- 1992-11-02 JP JP4317907A patent/JP2799271B2/ja not_active Expired - Fee Related
- 1992-11-03 CN CN92112704A patent/CN1041308C/zh not_active Expired - Fee Related
- 1992-11-04 US US07/971,370 patent/US5399712A/en not_active Expired - Fee Related
-
1997
- 1997-11-17 GR GR970403040T patent/GR3025396T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5399712A (en) | 1995-03-21 |
| DE69221988T2 (de) | 1998-02-05 |
| JP2799271B2 (ja) | 1998-09-17 |
| ES2107487T3 (es) | 1997-12-01 |
| ATE157664T1 (de) | 1997-09-15 |
| JPH05221977A (ja) | 1993-08-31 |
| EP0540956B1 (en) | 1997-09-03 |
| EP0540956A1 (en) | 1993-05-12 |
| GB9123396D0 (en) | 1991-12-18 |
| DE69221988D1 (de) | 1997-10-09 |
| NZ244952A (en) | 1995-10-26 |
| CN1072409A (zh) | 1993-05-26 |
| GR3025396T3 (en) | 1998-02-27 |
| CN1041308C (zh) | 1998-12-23 |
| AU658017B2 (en) | 1995-03-30 |
| CA2081805A1 (en) | 1993-05-05 |
| AU2741992A (en) | 1993-05-06 |
| ZA928340B (en) | 1993-05-04 |
| CA2081805C (en) | 1999-12-14 |
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