PE20060384A1 - Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversa - Google Patents
Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversaInfo
- Publication number
- PE20060384A1 PE20060384A1 PE2005000877A PE2005000877A PE20060384A1 PE 20060384 A1 PE20060384 A1 PE 20060384A1 PE 2005000877 A PE2005000877 A PE 2005000877A PE 2005000877 A PE2005000877 A PE 2005000877A PE 20060384 A1 PE20060384 A1 PE 20060384A1
- Authority
- PE
- Peru
- Prior art keywords
- benzoic acid
- inhibitors
- halo
- nucleosid
- acid derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/68—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 Y R2 SON CADA UNO H, HALO, CIANO, HALOALQUILO C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS; R3 ES HALO; R4 ES ALQUILO C1-C4, HALO, NITRO; R5 Y R6 SON CADA UNO H, HALO, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: ACIDO 3-METIL-4-[{2-[(4-CLORO-2-(5-FLUORO-3-TRIFLUOROMETIL)BENZOIL)FENOXI]-1-OXOETIL}AMINO]BENZOICO; ACIDO 2,5-DIFLUORO-3- METIL-4-[{2-[(4-CLORO-2-(5-FLUORO-3-CIANO)BENZOIL)FENOXI]-1-OXOETIL}AMINO]BENZOICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TRANSCRITASA INVERSA DEL VIH, UTILES EN EL TRATAMIENTO O PREVENCION DEL SIDA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59822704P | 2004-08-02 | 2004-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060384A1 true PE20060384A1 (es) | 2006-06-05 |
Family
ID=35786846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000877A PE20060384A1 (es) | 2004-08-02 | 2005-07-27 | Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversa |
Country Status (10)
Country | Link |
---|---|
US (2) | US20060025480A1 (es) |
EP (1) | EP1781600B1 (es) |
JP (1) | JP4847450B2 (es) |
AR (1) | AR050032A1 (es) |
AT (1) | ATE526309T1 (es) |
CA (1) | CA2573315C (es) |
PE (1) | PE20060384A1 (es) |
TW (1) | TW200616933A (es) |
UY (1) | UY29042A1 (es) |
WO (1) | WO2006012733A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2577144C (en) * | 2004-09-30 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Alkynyl compounds as non-nucleoside reverse transcriptase inhibitors |
CL2008001631A1 (es) * | 2007-06-06 | 2009-01-02 | Smithkline Beecham Corp | Compuestos derivados de heterociclos sustituidos, con la presencia de un grupo fenoxi, inhibidores de transcriptasa inversa; composicion farmaceutica; y uso en el tratamiento de infecciones virales por vih. |
WO2009018657A1 (en) * | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US20100286131A1 (en) * | 2007-08-03 | 2010-11-11 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
EP2234977A4 (en) | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
CN102212022A (zh) * | 2011-04-20 | 2011-10-12 | 复旦大学 | 二苯甲醇衍生物及其制备方法和用途 |
CN102219717A (zh) * | 2011-04-20 | 2011-10-19 | 复旦大学 | N-苯基芳基甲酰胺衍生物及其制备方法和用途 |
CN102206177A (zh) * | 2011-04-20 | 2011-10-05 | 复旦大学 | 1-萘基苯甲酮衍生物及其制备方法和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9920872D0 (en) | 1999-09-04 | 1999-11-10 | Glaxo Group Ltd | Benzophenones as inhibitors of reverse transcriptase |
TWI270547B (en) | 2000-06-16 | 2007-01-11 | Boehringer Ingelheim Ca Ltd | Non-nucleoside reverse transcriptase inhibitors |
JP2004525914A (ja) | 2001-03-02 | 2004-08-26 | スミスクライン ビーチャム コーポレーション | 逆転写酵素阻害剤としてのベンゾフェノン類 |
US20050009812A1 (en) | 2001-10-05 | 2005-01-13 | Takuya Seko | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists |
BR0308588A (pt) | 2002-03-11 | 2005-02-15 | Tibotec Pharm Ltd | Inibidores de entrada de molécula pequena |
CA2493457A1 (en) | 2002-07-24 | 2004-01-29 | Ptc Therapeutics, Inc. | Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
-
2005
- 2005-07-19 US US11/184,689 patent/US20060025480A1/en not_active Abandoned
- 2005-07-27 PE PE2005000877A patent/PE20060384A1/es not_active Application Discontinuation
- 2005-07-28 JP JP2007524145A patent/JP4847450B2/ja not_active Expired - Fee Related
- 2005-07-28 EP EP05770583A patent/EP1781600B1/en not_active Not-in-force
- 2005-07-28 CA CA2573315A patent/CA2573315C/en not_active Expired - Fee Related
- 2005-07-28 WO PCT/CA2005/001179 patent/WO2006012733A1/en active Application Filing
- 2005-07-28 AT AT05770583T patent/ATE526309T1/de not_active IP Right Cessation
- 2005-07-29 UY UY29042A patent/UY29042A1/es not_active Application Discontinuation
- 2005-07-29 AR ARP050103169A patent/AR050032A1/es unknown
- 2005-08-01 TW TW094126063A patent/TW200616933A/zh unknown
-
2008
- 2008-01-15 US US12/014,185 patent/US7569723B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2573315A1 (en) | 2006-02-09 |
US20060025480A1 (en) | 2006-02-02 |
AR050032A1 (es) | 2006-09-20 |
UY29042A1 (es) | 2006-03-31 |
EP1781600B1 (en) | 2011-09-28 |
US20080114068A1 (en) | 2008-05-15 |
WO2006012733A1 (en) | 2006-02-09 |
US7569723B2 (en) | 2009-08-04 |
EP1781600A4 (en) | 2008-12-10 |
TW200616933A (en) | 2006-06-01 |
JP4847450B2 (ja) | 2011-12-28 |
ATE526309T1 (de) | 2011-10-15 |
CA2573315C (en) | 2011-03-29 |
EP1781600A1 (en) | 2007-05-09 |
JP2008508328A (ja) | 2008-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20060384A1 (es) | Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversa | |
PE20121157A1 (es) | Compuestos heterociclicos como inhibidores de proteasas serinas | |
PE20130385A1 (es) | Derivados del acido naft-2-ilacetico para tratar el sida | |
PE20081836A1 (es) | Derivados de piperidina como inhibidores de la sintasa de acido graso | |
PE20010628A1 (es) | Compuestos de amina ciclica, su produccion y su uso | |
PE20060589A1 (es) | FENILAMINOTIAZOLES SUSTITUIDOS COMO AGONISTAS DE ADENOSINA A1 Y A2b | |
PE20090880A1 (es) | Compuestos heterociclicos como inhibidores de fosfatidilinositol 3-cinasa | |
PE20080906A1 (es) | Derivados heteroarilo como inhibidores de citocina | |
PE20061153A1 (es) | Compuestos heterociclicos como inhibidores del factor viia | |
PE20080890A1 (es) | DERIVADOS DE IMIDAZOLONA E IMIDAZOLIDINONA COMO INHIBIDORES DE LA 11b-HSD1 PARA LA DIABETES | |
EA200401437A1 (ru) | Ненуклеозидные ингибиторы обратной транскриптазы для лечения вич инфекции, способ их получения (варианты), способ увеличения периода полупревращения ненуклеозидного соединения, обладающего активностью против ретровирусов, и способ получения фармацевтической композиции, обладающей специфичностью к лейкоцитам | |
PE20071326A1 (es) | Inhibidores de la polimerasa viral | |
PE20060937A1 (es) | Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2) | |
PE20060999A1 (es) | Composiciones farmaceuticas que contienen un diuretico y un bloqueador del receptor de angiotensina ii | |
PE20060316A1 (es) | Derivados de prolina como inhibidores de dipeptidil peptidasa-iv | |
PE20091177A1 (es) | Compuestos heterociclicos antiviricos | |
PE20060691A1 (es) | Serinamidas sustituidas por benzoilo | |
TW200606151A (en) | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions | |
PE20050013A1 (es) | Composiciones farmaceuticas como inhibidores de la proteasa del virus de la hepatitis c | |
PE20050867A1 (es) | DERIVADOS DE PIPERAZINA COMO INHIBIDORES DE LA INTERACCION DE gp 120 CON CD4 | |
PE20090641A1 (es) | Amidas heterociclicas | |
CO5601029A2 (es) | Inhibidores no nucleosidos de transcriptasa inversa i para el tratamiento de enfermedades mediadas por vih | |
PE20040120A1 (es) | Derivados de quinolina como antagonistas de npy | |
PE20070359A1 (es) | Inhibidores de pirimidinilpirazol de aurora quinasas | |
PE20071132A1 (es) | Compuestos macrociclicos como inhibidores del factor viia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |