PE20060384A1 - Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversa - Google Patents

Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversa

Info

Publication number
PE20060384A1
PE20060384A1 PE2005000877A PE2005000877A PE20060384A1 PE 20060384 A1 PE20060384 A1 PE 20060384A1 PE 2005000877 A PE2005000877 A PE 2005000877A PE 2005000877 A PE2005000877 A PE 2005000877A PE 20060384 A1 PE20060384 A1 PE 20060384A1
Authority
PE
Peru
Prior art keywords
benzoic acid
inhibitors
halo
nucleosid
acid derivatives
Prior art date
Application number
PE2005000877A
Other languages
English (en)
Inventor
Bruno Simoneau
Christiane Yoakim
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20060384A1 publication Critical patent/PE20060384A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/68—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 Y R2 SON CADA UNO H, HALO, CIANO, HALOALQUILO C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS; R3 ES HALO; R4 ES ALQUILO C1-C4, HALO, NITRO; R5 Y R6 SON CADA UNO H, HALO, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: ACIDO 3-METIL-4-[{2-[(4-CLORO-2-(5-FLUORO-3-TRIFLUOROMETIL)BENZOIL)FENOXI]-1-OXOETIL}AMINO]BENZOICO; ACIDO 2,5-DIFLUORO-3- METIL-4-[{2-[(4-CLORO-2-(5-FLUORO-3-CIANO)BENZOIL)FENOXI]-1-OXOETIL}AMINO]BENZOICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TRANSCRITASA INVERSA DEL VIH, UTILES EN EL TRATAMIENTO O PREVENCION DEL SIDA
PE2005000877A 2004-08-02 2005-07-27 Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversa PE20060384A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59822704P 2004-08-02 2004-08-02

Publications (1)

Publication Number Publication Date
PE20060384A1 true PE20060384A1 (es) 2006-06-05

Family

ID=35786846

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000877A PE20060384A1 (es) 2004-08-02 2005-07-27 Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversa

Country Status (10)

Country Link
US (2) US20060025480A1 (es)
EP (1) EP1781600B1 (es)
JP (1) JP4847450B2 (es)
AR (1) AR050032A1 (es)
AT (1) ATE526309T1 (es)
CA (1) CA2573315C (es)
PE (1) PE20060384A1 (es)
TW (1) TW200616933A (es)
UY (1) UY29042A1 (es)
WO (1) WO2006012733A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006034583A1 (en) * 2004-09-30 2006-04-06 Boehringer Ingelheim International Gmbh & Co Kg Alkynyl based dervatives of benzophenone as non-nucleoside reverse transcriptase inhibitors
TW200901969A (en) * 2007-06-06 2009-01-16 Smithkline Beecham Corp Chemical compounds
US20100286131A1 (en) * 2007-08-03 2010-11-11 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
CA2693997C (en) * 2007-08-03 2013-01-15 Pierre L. Beaulieu Viral polymerase inhibitors
MX2010006313A (es) 2007-12-19 2010-06-25 Boehringer Ingelheim Int Inhibidores de la polimerasa virica.
CN102219717A (zh) * 2011-04-20 2011-10-19 复旦大学 N-苯基芳基甲酰胺衍生物及其制备方法和用途
CN102206177A (zh) * 2011-04-20 2011-10-05 复旦大学 1-萘基苯甲酮衍生物及其制备方法和用途
CN102212022A (zh) * 2011-04-20 2011-10-12 复旦大学 二苯甲醇衍生物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920872D0 (en) * 1999-09-04 1999-11-10 Glaxo Group Ltd Benzophenones as inhibitors of reverse transcriptase
TWI270547B (en) 2000-06-16 2007-01-11 Boehringer Ingelheim Ca Ltd Non-nucleoside reverse transcriptase inhibitors
EP1363877A2 (en) * 2001-03-02 2003-11-26 SmithKline Beecham Corporation Benzophenones as inhibitors of reverse transcriptase
US20050009812A1 (en) 2001-10-05 2005-01-13 Takuya Seko Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
RU2395491C2 (ru) 2002-03-11 2010-07-27 Тиботек Фармасьютикалз Лтд. Малые молекулы-ингибиторы проникновения
EP1525185A1 (en) 2002-07-24 2005-04-27 PTC Therapeutics, Inc. Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
US20060025480A1 (en) 2006-02-02
ATE526309T1 (de) 2011-10-15
CA2573315C (en) 2011-03-29
WO2006012733A1 (en) 2006-02-09
US7569723B2 (en) 2009-08-04
CA2573315A1 (en) 2006-02-09
AR050032A1 (es) 2006-09-20
JP2008508328A (ja) 2008-03-21
EP1781600B1 (en) 2011-09-28
UY29042A1 (es) 2006-03-31
US20080114068A1 (en) 2008-05-15
JP4847450B2 (ja) 2011-12-28
EP1781600A4 (en) 2008-12-10
EP1781600A1 (en) 2007-05-09
TW200616933A (en) 2006-06-01

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