UY29042A1 - Derivados de ácido benzoico como inhibidores no nucleósidos de la transcriptasa inversa - Google Patents

Derivados de ácido benzoico como inhibidores no nucleósidos de la transcriptasa inversa

Info

Publication number
UY29042A1
UY29042A1 UY29042A UY29042A UY29042A1 UY 29042 A1 UY29042 A1 UY 29042A1 UY 29042 A UY29042 A UY 29042A UY 29042 A UY29042 A UY 29042A UY 29042 A1 UY29042 A1 UY 29042A1
Authority
UY
Uruguay
Prior art keywords
inhibitors
nucleosid
derivatives
benzoic acid
reverse transcript
Prior art date
Application number
UY29042A
Other languages
English (en)
Inventor
Bruno Simoneau
Christiane Yoakim
Jeffrey O Meara
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of UY29042A1 publication Critical patent/UY29042A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/68—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

Compuestos de la fórmula (I): en la que R1, R2, R3, R4, R5 y R6 son tal como se define en la presente. Los compuestos son útiles como inhibidores de la transcripta inversa contra el VIH. En particular, los compuestos son activos contra cepas del VIH mutantes, simples o dobles y del tipo silvestre.
UY29042A 2004-08-02 2005-07-29 Derivados de ácido benzoico como inhibidores no nucleósidos de la transcriptasa inversa UY29042A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59822704P 2004-08-02 2004-08-02

Publications (1)

Publication Number Publication Date
UY29042A1 true UY29042A1 (es) 2006-03-31

Family

ID=35786846

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29042A UY29042A1 (es) 2004-08-02 2005-07-29 Derivados de ácido benzoico como inhibidores no nucleósidos de la transcriptasa inversa

Country Status (10)

Country Link
US (2) US20060025480A1 (es)
EP (1) EP1781600B1 (es)
JP (1) JP4847450B2 (es)
AR (1) AR050032A1 (es)
AT (1) ATE526309T1 (es)
CA (1) CA2573315C (es)
PE (1) PE20060384A1 (es)
TW (1) TW200616933A (es)
UY (1) UY29042A1 (es)
WO (1) WO2006012733A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2577144C (en) * 2004-09-30 2011-06-21 Boehringer Ingelheim International Gmbh Alkynyl compounds as non-nucleoside reverse transcriptase inhibitors
TW200901969A (en) * 2007-06-06 2009-01-16 Smithkline Beecham Corp Chemical compounds
WO2009018656A1 (en) * 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2009018657A1 (en) * 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EP2234977A4 (en) 2007-12-19 2011-04-13 Boehringer Ingelheim Int VIRAL POLYMERASE INHIBITORS
CN102219717A (zh) * 2011-04-20 2011-10-19 复旦大学 N-苯基芳基甲酰胺衍生物及其制备方法和用途
CN102212022A (zh) * 2011-04-20 2011-10-12 复旦大学 二苯甲醇衍生物及其制备方法和用途
CN102206177A (zh) * 2011-04-20 2011-10-05 复旦大学 1-萘基苯甲酮衍生物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920872D0 (en) * 1999-09-04 1999-11-10 Glaxo Group Ltd Benzophenones as inhibitors of reverse transcriptase
TWI270547B (en) 2000-06-16 2007-01-11 Boehringer Ingelheim Ca Ltd Non-nucleoside reverse transcriptase inhibitors
WO2002070470A2 (en) * 2001-03-02 2002-09-12 Smithkline Beecham Corporation Benzophenones as inhibitors of reverse transcriptase
EP1438973A4 (en) 2001-10-05 2005-07-13 Ono Pharmaceutical Co MEANS FOR THE TREATMENT OF STRESS-RELATED DISEASES WITH MITOCHONDRIENE BENZODIAZEPINE RECEPTOR ANTAGONISTS
CN1652759A (zh) 2002-03-11 2005-08-10 泰博特克药品有限公司 小分子进入抑制剂
AU2003254157A1 (en) 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
WO2006012733A1 (en) 2006-02-09
EP1781600A4 (en) 2008-12-10
US20080114068A1 (en) 2008-05-15
EP1781600B1 (en) 2011-09-28
US7569723B2 (en) 2009-08-04
ATE526309T1 (de) 2011-10-15
JP4847450B2 (ja) 2011-12-28
CA2573315C (en) 2011-03-29
JP2008508328A (ja) 2008-03-21
US20060025480A1 (en) 2006-02-02
EP1781600A1 (en) 2007-05-09
TW200616933A (en) 2006-06-01
AR050032A1 (es) 2006-09-20
CA2573315A1 (en) 2006-02-09
PE20060384A1 (es) 2006-06-05

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20160524