CY1115633T1 - Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης - Google Patents

Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης

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Publication number
CY1115633T1
CY1115633T1 CY20141100820T CY141100820T CY1115633T1 CY 1115633 T1 CY1115633 T1 CY 1115633T1 CY 20141100820 T CY20141100820 T CY 20141100820T CY 141100820 T CY141100820 T CY 141100820T CY 1115633 T1 CY1115633 T1 CY 1115633T1
Authority
CY
Cyprus
Prior art keywords
pyrozine
pyridene
producers
oxidation inhibitors
nadph oxidation
Prior art date
Application number
CY20141100820T
Other languages
English (en)
Inventor
Patrick Page
Mike Orchard
Laetitia Fioraso-Cartier
Bianca Mottironi
Original Assignee
Genkyotex Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genkyotex Sa filed Critical Genkyotex Sa
Publication of CY1115633T1 publication Critical patent/CY1115633T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Abstract

Η παρούσα εφεύρεση αναφέρεται σε παράγωγα πυραζολο πυριδίνης του Τύπου (Ι), σε φαρμακευτική σύνθεση αυτών και στη χρήση τους για τη θεραπευτική αγωγή ή/και προφύλαξη από διαταραχές ή καταστάσεις που σχετίζονται με ανηγμένη μορφή του φωσφορικού νικοτιναμιδο αδενινο δινουκλεοτιδίου-οξειδάση (NADPH Οξειδάση).
CY20141100820T 2007-03-22 2014-10-09 Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης CY1115633T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89628407P 2007-03-22 2007-03-22
EP07109555A EP2002835A1 (en) 2007-06-04 2007-06-04 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP12187254.3A EP2545918B1 (en) 2007-03-22 2008-03-20 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors

Publications (1)

Publication Number Publication Date
CY1115633T1 true CY1115633T1 (el) 2017-01-04

Family

ID=38653574

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20131100067T CY1113556T1 (el) 2007-03-22 2013-01-23 Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης
CY20141100820T CY1115633T1 (el) 2007-03-22 2014-10-09 Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20131100067T CY1113556T1 (el) 2007-03-22 2013-01-23 Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης

Country Status (18)

Country Link
US (2) US8389518B2 (el)
EP (3) EP2002835A1 (el)
JP (2) JP5715340B2 (el)
CN (2) CN105061422B (el)
AU (1) AU2008228186C1 (el)
BR (1) BRPI0808824B8 (el)
CA (1) CA2676954C (el)
CY (2) CY1113556T1 (el)
DK (2) DK2545918T3 (el)
ES (2) ES2398994T3 (el)
HK (2) HK1141734A1 (el)
HR (2) HRP20130143T1 (el)
IL (1) IL201009A (el)
PL (2) PL2545918T3 (el)
PT (2) PT2139477E (el)
RS (2) RS53641B1 (el)
SI (2) SI2139477T1 (el)
WO (1) WO2008113856A1 (el)

Families Citing this family (39)

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EP2000176A1 (en) 2007-06-04 2008-12-10 GenKyo Tex Tetrahydroindole derivatives as NADPH Oxidase inhibitors
EP2166008A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2166010A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
WO2011009119A2 (en) * 2009-07-17 2011-01-20 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating fibrotic disorders
EP2305679A1 (en) * 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
US9029545B2 (en) * 2009-12-18 2015-05-12 Glaxosmithkline Intellectual Property Limited Thienopyridine NOX2 inhibitors
EP2361911A1 (en) * 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
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US9428478B2 (en) 2011-06-13 2016-08-30 Emory University Piperazine derivatives, compositions, and uses related thereto
GB2494679A (en) * 2011-09-15 2013-03-20 Univ Jw Goethe Frankfurt Main Treatment of neuropathic pain and nerve injury by Nox4 inhibition
EP2591782A1 (en) * 2011-11-11 2013-05-15 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof
US9688960B2 (en) 2013-03-14 2017-06-27 Eastern Virginia Medical School Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting NOX-1
EP2857399A1 (en) 2013-10-03 2015-04-08 GenKyoTex SA Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction
EP3098220A1 (en) 2015-05-28 2016-11-30 GenKyoTex SA Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof
KR20180014832A (ko) 2015-06-22 2018-02-09 액테리온 파마슈티칼 리미티드 Nadph 옥시다제 4 억제제
WO2017196982A1 (en) * 2016-05-10 2017-11-16 Georgia State University Research Foundation, Inc. Bicyclic fused pyrazole derivatives for the treatment of rsv
EP3454896A4 (en) 2016-05-10 2020-03-25 Georgia State University Research Foundation, Inc. HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF RSV
US20180072718A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine compounds and uses thereof
US10280164B2 (en) 2016-09-09 2019-05-07 Incyte Corporation Pyrazolopyridone compounds and uses thereof
KR102507967B1 (ko) 2016-09-09 2023-03-09 인사이트 코포레이션 Hpk1 조절제로서의 피라졸로피리딘 유도체 및 암을 치료하기 위한 이의 용도
TW201811799A (zh) 2016-09-09 2018-04-01 美商英塞特公司 吡唑并嘧啶化合物及其用途
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