BRPI0808824B8 - derivado de pirazol piridina como inibidores de nadph oxidase, composição farmacêutica, e, uso de um derivado de pirazol piridina - Google Patents

derivado de pirazol piridina como inibidores de nadph oxidase, composição farmacêutica, e, uso de um derivado de pirazol piridina

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Publication number
BRPI0808824B8
BRPI0808824B8 BRPI0808824A BRPI0808824A BRPI0808824B8 BR PI0808824 B8 BRPI0808824 B8 BR PI0808824B8 BR PI0808824 A BRPI0808824 A BR PI0808824A BR PI0808824 A BRPI0808824 A BR PI0808824A BR PI0808824 B8 BRPI0808824 B8 BR PI0808824B8
Authority
BR
Brazil
Prior art keywords
pyridine derivative
pyrazole pyridine
pharmaceutical composition
pyrazole
nadph oxidase
Prior art date
Application number
BRPI0808824A
Other languages
English (en)
Inventor
Mottironi Bianca
Fioraso-Cartier Laeticia
Orchard Mike
Page Patrick
Original Assignee
Genkyo Tex Sa
Genkyotex Suisse Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genkyo Tex Sa, Genkyotex Suisse Sa filed Critical Genkyo Tex Sa
Publication of BRPI0808824A2 publication Critical patent/BRPI0808824A2/pt
Publication of BRPI0808824B1 publication Critical patent/BRPI0808824B1/pt
Publication of BRPI0808824B8 publication Critical patent/BRPI0808824B8/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

derivado de pirazol piridina, composição farmacêutica, e, uso de um derivado de pirazol piridina. a presente invenção diz respeito aos derivados de pirazol piridina da fórmula (i), a uma composição farmacêutica destes e ao eu uso para o tratamento e/ou profilaxia de distúrbios ou condições relacionadas com a nicotinamida adenina dinucleotídeo fosfato oxidase (nadph oxidase).
BRPI0808824A 2007-03-22 2008-03-20 derivado de pirazol piridina como inibidores de nadph oxidase, composição farmacêutica, e, uso de um derivado de pirazol piridina BRPI0808824B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89628407P 2007-03-22 2007-03-22
US60/896284 2007-03-22
EP07109555.8 2007-06-04
EP07109555A EP2002835A1 (en) 2007-06-04 2007-06-04 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
PCT/EP2008/053390 WO2008113856A1 (en) 2007-03-22 2008-03-20 Pyrazolo pyridine derivatives as nadph oxidase inhibitors

Publications (3)

Publication Number Publication Date
BRPI0808824A2 BRPI0808824A2 (pt) 2014-08-19
BRPI0808824B1 BRPI0808824B1 (pt) 2020-10-13
BRPI0808824B8 true BRPI0808824B8 (pt) 2021-05-25

Family

ID=38653574

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808824A BRPI0808824B8 (pt) 2007-03-22 2008-03-20 derivado de pirazol piridina como inibidores de nadph oxidase, composição farmacêutica, e, uso de um derivado de pirazol piridina

Country Status (18)

Country Link
US (2) US8389518B2 (pt)
EP (3) EP2002835A1 (pt)
JP (2) JP5715340B2 (pt)
CN (2) CN101686967B (pt)
AU (1) AU2008228186C1 (pt)
BR (1) BRPI0808824B8 (pt)
CA (1) CA2676954C (pt)
CY (2) CY1113556T1 (pt)
DK (2) DK2545918T3 (pt)
ES (2) ES2398994T3 (pt)
HK (2) HK1141734A1 (pt)
HR (2) HRP20130143T1 (pt)
IL (1) IL201009A (pt)
PL (2) PL2139477T3 (pt)
PT (2) PT2545918E (pt)
RS (2) RS52640B (pt)
SI (2) SI2545918T1 (pt)
WO (1) WO2008113856A1 (pt)

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EP2002835A1 (en) 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2000176A1 (en) 2007-06-04 2008-12-10 GenKyo Tex Tetrahydroindole derivatives as NADPH Oxidase inhibitors
EP2166010A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166008A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2165707A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
WO2011009119A2 (en) * 2009-07-17 2011-01-20 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating fibrotic disorders
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
JP5799024B2 (ja) * 2009-12-18 2015-10-21 グラクソスミスクライン、インテレクチュアル、プロパティー、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｌｉｍｉｔｅｄ 新規化合物
EP2361912A1 (en) * 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
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WO2012173952A1 (en) 2011-06-13 2012-12-20 Emory University Piperazine derivatives, compositions, and uses related thereto
GB2494679A (en) * 2011-09-15 2013-03-20 Univ Jw Goethe Frankfurt Main Treatment of neuropathic pain and nerve injury by Nox4 inhibition
EP2591782A1 (en) * 2011-11-11 2013-05-15 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof
WO2014153227A1 (en) * 2013-03-14 2014-09-25 Eastern Virginia Medical School Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting nox-1
EP2857399A1 (en) 2013-10-03 2015-04-08 GenKyoTex SA Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction
EP3098220A1 (en) 2015-05-28 2016-11-30 GenKyoTex SA Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof
JP6802194B2 (ja) * 2015-06-22 2020-12-16 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｎａｄｐｈオキシダーゼ４阻害剤
US10906899B2 (en) * 2016-05-10 2021-02-02 Georgia State University Research Foundation, Inc. Bicyclic fused pyrazole derivatives for the treatment of RSV
CA3023922C (en) 2016-05-10 2023-04-18 Georgia State University Research Foundation, Inc. Heterocyclic derivatives for the treatment of rsv
US20180072718A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine compounds and uses thereof
US20180072741A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyrimidine compounds and uses thereof
US10280164B2 (en) 2016-09-09 2019-05-07 Incyte Corporation Pyrazolopyridone compounds and uses thereof
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