MX2012002876A - Derivados de dihidropteridinona, proceso para su preparacion y uso farmaceutico. - Google Patents

Derivados de dihidropteridinona, proceso para su preparacion y uso farmaceutico.

Info

Publication number
MX2012002876A
MX2012002876A MX2012002876A MX2012002876A MX2012002876A MX 2012002876 A MX2012002876 A MX 2012002876A MX 2012002876 A MX2012002876 A MX 2012002876A MX 2012002876 A MX2012002876 A MX 2012002876A MX 2012002876 A MX2012002876 A MX 2012002876A
Authority
MX
Mexico
Prior art keywords
preparation process
derivatives
pharmaceutical use
dihydropteridinone
dihydropteridinone derivatives
Prior art date
Application number
MX2012002876A
Other languages
English (en)
Inventor
Peng Cho Tang
Hao Zheng
Nong Zhang
Baolei Zhang
Weimin Wang
Lin Wu
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2012002876A publication Critical patent/MX2012002876A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen derivados dihidroperidinona, proceso para su preparación y su uso farmacéutico. Especialmente, se describen nuevos derivados de dihidroperidinona representados por la fórmula general (I), en donde cada substituyente de la fórmula general (I) se define como en la descripción, su proceso de preparación, composiciones farmacéuticas que comprenden los derivados y su uso como agentes terapéuticos, en especial como inhibidores de Plk quinasa. (ver fórmula (I)).
MX2012002876A 2009-09-22 2010-09-14 Derivados de dihidropteridinona, proceso para su preparacion y uso farmaceutico. MX2012002876A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2009101963994A CN102020643A (zh) 2009-09-22 2009-09-22 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
PCT/CN2010/001405 WO2011035534A1 (zh) 2009-09-22 2010-09-14 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
MX2012002876A true MX2012002876A (es) 2012-04-20

Family

ID=43795321

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012002876A MX2012002876A (es) 2009-09-22 2010-09-14 Derivados de dihidropteridinona, proceso para su preparacion y uso farmaceutico.

Country Status (13)

Country Link
US (1) US8691822B2 (es)
EP (1) EP2481739B1 (es)
JP (1) JP5767642B2 (es)
KR (1) KR101810650B1 (es)
CN (2) CN102020643A (es)
AU (1) AU2010297921B2 (es)
BR (1) BR112012006404A2 (es)
CA (1) CA2774731C (es)
HK (1) HK1161878A1 (es)
MX (1) MX2012002876A (es)
RU (1) RU2559881C2 (es)
WO (1) WO2011035534A1 (es)
ZA (1) ZA201201349B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102762568A (zh) 2009-12-23 2012-10-31 伊兰药品公司 作为polo样激酶的抑制剂的蝶啶酮
EP2776444A4 (en) 2011-11-10 2015-07-22 Osi Pharmaceuticals Llc dihydropteridinones
JP6075736B2 (ja) * 2011-12-21 2017-02-08 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． ピロール−６員ヘテロアリール環誘導体、その合成法およびその医薬用途
MX2016001037A (es) 2013-07-25 2016-11-10 Dana Farber Cancer Inst Inc Inhibidores de factores de transcripción y usos.
CN103664845B (zh) * 2013-12-27 2016-02-10 湖南欧亚生物有限公司 一种Plk激酶抑制剂药物中间体7-氨基-2,3-二氢苯并呋喃-4-甲酸的制备方法
WO2015117053A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
MX2016009975A (es) * 2014-01-31 2016-10-31 Dana Farber Cancer Inst Inc Derivados de dihidropteridinona y sus usos.
CN106715437A (zh) 2014-08-08 2017-05-24 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
DK3237418T3 (da) 2014-12-23 2019-05-13 Novartis Ag Triazolopyrimidinforbindelser og anvendelser deraf
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
AU2016319116B2 (en) 2015-09-11 2020-10-01 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
SG10202007099TA (en) 2015-09-11 2020-08-28 Dana Farber Cancer Inst Inc Acetamide thienotriazoldiazepines and uses thereof
KR20180081809A (ko) 2015-11-25 2018-07-17 다나-파버 캔서 인스티튜트 인크. 2가 브로모도메인 억제제 및 그의 용도
KR20220047823A (ko) * 2019-08-16 2022-04-19 싸이클라셀 리미티드 피리미디노-디아제핀 유도체의 제조 방법
CN110540519B (zh) * 2019-09-05 2022-12-02 宁波大学 一种1,6-烯炔类化合物与酮类化合物的自由基环化反应方法
US20230365566A1 (en) * 2020-02-28 2023-11-16 Remix Therapeutics Inc. Heterocyclic amides and their use for modulating splicing
WO2023034812A1 (en) * 2021-08-30 2023-03-09 Remix Therapeutics Inc. Compounds and methods for modulating splicing

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US7169778B2 (en) 1999-09-15 2007-01-30 Warner-Lambert Company Pteridinones as kinase inhibitors
UY27427A1 (es) 2001-09-04 2003-03-31 Boehringer Ingelheim Pharma Nuevas dihidro-pteridinonas, procedimientos para su preparación y su utilización como medicamentos
US6806272B2 (en) 2001-09-04 2004-10-19 Boehringer Ingelheim Pharma Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
KR20050071471A (ko) 2002-08-08 2005-07-07 스미스클라인 비참 코포레이션 티오펜 화합물
US6861422B2 (en) 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
PT1599478E (pt) * 2003-02-26 2007-05-31 Boehringer Ingelheim Pharma Di-hidropteridinonas, proceso para a sua preparação e a sua utilização como medicamento
US7728134B2 (en) 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
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EP1953163A1 (en) 2007-02-01 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Pteridinone derivatives as PI3-kinases inhibitors
CN101392001A (zh) 2007-09-21 2009-03-25 上海恒瑞医药有限公司 氨甲酰类衍生物、其制备方法及其在医药上的用途

Also Published As

Publication number Publication date
ZA201201349B (en) 2012-10-31
CN102421778B (zh) 2013-10-16
US20120184543A1 (en) 2012-07-19
CA2774731A1 (en) 2011-03-31
HK1161878A1 (en) 2012-08-10
RU2012112050A (ru) 2013-10-27
JP2013505203A (ja) 2013-02-14
WO2011035534A1 (zh) 2011-03-31
CA2774731C (en) 2017-05-23
EP2481739A4 (en) 2013-02-27
AU2010297921B2 (en) 2014-12-11
AU2010297921A1 (en) 2012-05-03
CN102421778A (zh) 2012-04-18
EP2481739A1 (en) 2012-08-01
BR112012006404A2 (pt) 2016-04-12
KR101810650B1 (ko) 2018-01-25
JP5767642B2 (ja) 2015-08-19
US8691822B2 (en) 2014-04-08
RU2559881C2 (ru) 2015-08-20
EP2481739B1 (en) 2016-12-14
CN102020643A (zh) 2011-04-20
KR20120072367A (ko) 2012-07-03

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